Abstract:
:Patients with left main (LM) coronary artery disease (CAD) are at the highest risk of cardiovascular events. We evaluated possible gene polymorphisms of tumor protein 53 ( TP53, rs1042522, p.Arg72Pro) that can differentiate LM-CAD from patients with more peripheral CAD (MP-CAD) and healthy participants (control group) in 520 individuals (LM-CAD, n = 175; MP-CAD, n = 185; and control group, n = 160). Patients with LM-CAD had the lowest Arg/Arg genotype frequency (36.0%) compared with the MP-CAD (57.3%) and control groups (61.9%), P < .001 for both comparisons. Similarly, the Arg allele was more frequent in the control group than in patients with MP-CAD (78.8% vs 73.2%; P = .007) and LM-CAD (78.8% vs 64.0%; P < .001). The Arg/Pro genotype was more frequent in the LM-CAD group compared with the MP-CAD and control groups (56.0, 31.9, and 33.8, respectively, P < .001 for both comparisons). Furthermore, the frequency of Arg/Arg genotypes was the lowest in the LM-CAD group compared with the MP-CAD and control groups. Knowing that TP53 is an antioncogene protein that acts as a tumor suppressor and regulator of apoptosis, the lowest frequency of Arg/Arg genotype observed in these high-risk patients may indicate lower protection from the atherosclerosis process. Replication studies are needed to evaluate this association.
journal_name
Angiologyjournal_title
Angiologyauthors
Kolovou V,Tsipis A,Mihas C,Katsiki N,Vartela V,Koutelou M,Manolopoulou D,Leondiadis E,Iakovou I,Mavrogieni S,Kolovou Gdoi
10.1177/0003319718760075subject
Has Abstractpub_date
2018-09-01 00:00:00pages
730-735issue
8eissn
0003-3197issn
1940-1574journal_volume
69pub_type
杂志文章相关文献
ANGIOLOGY文献大全abstract::This report describes a case of aneurysm of the ascending aorta with secondary, severe, aortic valve incompetence following temporal arteritis in a sixty-five-year-old woman. ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978703800909
更新日期:1987-09-01 00:00:00
abstract::Many recent studies have suggested that psoriasis, a chronic, inflammatory, immune-mediated skin disease, is associated with increased risk of cardiovascular disease (CVD). We aimed to compare arterial stiffness in psoriasis and control patient groups using the cardio-ankle vascular index (CAVI) and to determine wheth...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319716652284
更新日期:2017-08-01 00:00:00
abstract::Not only antiphospholipid antibodies (aPLs) but also other factors should be considered in assessing the risk of thrombosis development in patients with systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPLs). The kinds of risk factors, including past history of thrombotic event (PHTE), hypertension,...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970505600512
更新日期:2005-09-01 00:00:00
abstract::Although limb salvage rate has improved in critical limb ischemia (CLI), an improvement in CLI prognosis has been scarcely reported. Multidisciplinary therapy (MT) including revascularization, wound bed preparation, treatment of comorbidity, and education of patients with CLI may improve prognosis. The aim of this stu...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319714523113
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:To evaluate the prevalence of significant coronary artery disease (CAD) and nondiagnostic studies in patients referred for clinically indicated coronary angiography performed by 128 multidetector computed tomography (MDCT). METHODS:We examined patients referred for coronary computed tomography (CT) angiography...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319709335513
更新日期:2010-02-01 00:00:00
abstract::The proportion of individuals >80 years of age constitute an increasing proportion of patients who present with ST-segment elevation myocardial infarction (STEMI). The objective of this study is to evaluate in-hospital outcomes and 1-year survival of very elderly patients who present with an STEMI and undergo primary ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319717746520
更新日期:2018-09-01 00:00:00
abstract::The present study reports on the effects of a physical treatment modality in patients with intermittent claudication. During this treatment a major part of the skin surface is subjected to intermittent suction and pressure. In a previous, preliminary study the authors found a beneficial effect of this treatment in int...
journal_title:Angiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/000331979304400103
更新日期:1993-01-01 00:00:00
abstract::Lower extremity peripheral artery disease (PAD) is a powerful predictor of cardiovascular events and mortality. The ankle-brachial index (ABI) is an objective and standard diagnostic method to diagnose PAD (an ABI ≤ 0.9 is considered pathological). The American Heart Association (AHA) and the American College of Cardi...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319710366126
更新日期:2010-11-01 00:00:00
abstract::The purpose of this paper is to show, by noninvasive measurements, previously undocumented effects on cardiac work of the nitrate coronary vasodilator Pentaerythritol Tetranitrate (Peritrate). The chew-and-swallow 40-mg tablets of this drug were given to 10 patients of type II AHA classification. The Diastolic Time Te...
journal_title:Angiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/000331978203300605
更新日期:1982-06-01 00:00:00
abstract::The authors investigated the time-dependent action of atorvastatin and simvastatin on oxidative stress and cytokine levels immediately after the start of treatment. These factors play a role in endothelial dysfunction. Hyperlipidemic patients (n = 132) were assigned to treatment with 40 mg atorvastatin, 40 mg simvasta...
journal_title:Angiology
pub_type: 杂志文章,随机对照试验
doi:10.1177/000331970605700212
更新日期:2006-03-01 00:00:00
abstract::The aim of this international multicenter trial was to evaluate the effects of a new surgical device (Gore External Valve Support-EVS) and technique for external valvuloplasty of the long saphenous vein (LSV). Patients with superficial venous disease and venous hypertension due to pure superficial venous incompetence ...
journal_title:Angiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1177/000331970005100806
更新日期:2000-08-01 00:00:00
abstract::In this association study the authors compared the insertion/deletion (I/D) angiotensin-I converting enzyme (ACE) gene polymorphism in females and males with premature myocardial infarction (MI). I/D ACE gene polymorphism was tested in 738 subjects: 302 patients with MI (151 men and 151 women) and 436 healthy subjects...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970405500207
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To investigate precocious alterations in the artery wall of patients with primary antiphospholipid syndrome (APS). METHODS:We evaluated flow-mediated dilation (FMD) of the brachial artery and intima-media thickness (IMT) of carotid arteries in 16 patients and 16 healthy controls matched for age, gender, and ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319708315304
更新日期:2009-02-01 00:00:00
abstract::Intracranial aneurysm is a leading cause of stroke. Its treatment has evolved over the past 2 decades. This review summarizes the treatment strategies for intracranial aneurysms from 3 different perspectives: open surgery approach, transluminal treatment approach, and new technologies being used or trialed. We introdu...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319717700503
更新日期:2018-01-01 00:00:00
abstract::The perioperative prognosis of 81 diabetic patients after endarterectomy of the femoral artery was analyzed by a computer program and compared to the prognosis of a control group of 83 nondiabetic patients. The percentage of female patients in the group with diabetes mellitus was 22% in comparison with 8% of the contr...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331977802900706
更新日期:1978-07-01 00:00:00
abstract::The physiological basis of postischemic hyperemia is not yet fully understood. The present study investigated the effects of pharmacologic manipulation of the prostaglandin system on local hemodynamics. Strain-gauge plethysmography was used to study 8 normal subjects and 9 patients with obliterating arterial disease o...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979704800208
更新日期:1997-02-01 00:00:00
abstract::The prevalence of coronary artery disease is increasing in young adults. We evaluated the outcomes of different types of acute coronary syndrome in 917 patients undergoing coronary angiography aged ≤45 years. Male sex, smoking, dyslipidemia were the most important risk factors. ST-elevation myocardial infarction (STEM...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319720939444
更新日期:2020-11-01 00:00:00
abstract::An abnormal increase in anti-beta2-glycoprotein I antibodies (abeta2GPI) is capable of producing thrombosis and the vasculopathy-simulating antiphospholipid antibody (aPL). However, it is rarely described in cerebral ischemia without an association with aPL. The authors report a middle-aged man who experienced recurre...
journal_title:Angiology
pub_type: 杂志文章,评审
doi:10.1177/000331970105200211
更新日期:2001-02-01 00:00:00
abstract::Two patients suffering from idiopathic unilateral lower limb lymphedema were treated with a diet in which long-chain triglycerides (LCT) were drastically restricted. From the beginning of the treatment, a distinct improvement was observed in both patients, with reduction of the affected limb perimeters, decrease of ed...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979404500805
更新日期:1994-08-01 00:00:00
abstract::It has been shown that QT dispersion (QTD) increases during episodes of myocardial ischemia or infarction. However, no extensive data on the relation between the diseased coronary artery or the localization of stenosis and the QTD are available. The aim of the study was to examine the relation between QTD and diseased...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970105200106
更新日期:2001-01-01 00:00:00
abstract::Carotid artery atherosclerosis (CAA) represents a significant form of atherosclerosis with stroke as a major consequence. Whether it is a unique form of atherosclerosis is not established. However, this is not of major clinical relevance as no specific preventive measures over and above the established ones for cardio...
journal_title:Angiology
pub_type: 杂志文章,评审
doi:10.1177/0003319716669460
更新日期:2017-09-01 00:00:00
abstract::The effect of administration of aprotinin, a serine esterase inhibitor capable of inactivating kallikrein, on the extent and severity of acute myocardial ischemic injury and subsequent necrosis, was studied in 25 patients. Another group of 25 patients who did not receive aprotinin served as a control group.We administ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978003100708
更新日期:1980-07-01 00:00:00
abstract::Axillosubclavian vein thrombosis is seen relatively infrequently in clinical practice when compared with lower limb deep-venous thrombosis; however, it is a condition that can result in significant morbidity if managed suboptimally. A multimodal treatment approach has been increasingly adopted with thrombolysis and/or...
journal_title:Angiology
pub_type: 杂志文章,评审
doi:10.1177/0003319707305917
更新日期:2008-02-01 00:00:00
abstract::A forty-eight-year-old man presented with cavitary pulmonary tuberculosis and widening of the mediastinum. Mediastinal widening was due to multiple saccular aneurysms of the ascending aorta and the arch of the aorta. The various presentations of tubercular aortitis and the reasons for considering alternative etiology ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979004100411
更新日期:1990-04-01 00:00:00
abstract::Data from 2,298 measurements of pulmonary venous admixture (QS/QT) performed in 733 patients were analyzed and processed in order to develop a method for rapid and reliable estimation of QS/QT by a simplified approach. Formulae and charts were obtained, which are easily suitable for use in all settings, and permit est...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978803901205
更新日期:1988-12-01 00:00:00
abstract::Patients with intermittent claudication due to peripheral arterial disease (PAD) experience muscle aching during walking secondary to ischemia. The purpose of this study was to examine the effects of low-intensity pain-free exercise (LIPFE) on functional capacity of individuals with PAD. A total of 12 participants wit...
journal_title:Angiology
pub_type: 临床试验,杂志文章
doi:10.1177/0003319708322388
更新日期:2009-08-01 00:00:00
abstract::Intravascular ultrasound (IVUS) frequently reveals plaque formation at sites with a normal angiographic appearance. However, whether angiographically normal coronary arteries undergo adaptive expansion in vivo remains uncertain. The authors studied 12 patients (11 men, 1 woman; mean age fifty-three +/- ten years [mean...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979604700804
更新日期:1996-08-01 00:00:00
abstract:INTRODUCTION:Computed tomography angiography (CTA) is the gold standard follow-up modality after endovascular aneurysm repair (EVAR). A potential alternative noninvasive and less expensive modality is duplex ultrasound scanning (DUS). METHODS:We studied 314 follow-up paired scans (DUS and CTA) in 59 patients with EVAR...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319709348296
更新日期:2010-02-01 00:00:00
abstract::This study evaluated the effects of heart rate (HR) on brachial-ankle pulse wave velocity (baPWV) and ankle-brachial pressure index (ABI). Thirty-two patients without significant organic heart disease underwent elective cardiac catheterization or electrophysiologic study, and were then enrolled in right atrial pacing ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319706295481
更新日期:2007-02-01 00:00:00
abstract::The relationship between echocardiographically measured epicardial fat thickness (EFT) and plasma concentrations of leptin, ghrelin, and adiponectin has not been evaluated in patients with noncachectic heart failure (HF). Patients with noncachectic HF and age- and sex-matched controls did not differ significantly in E...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319712447978
更新日期:2013-04-01 00:00:00