Tumor Protein p53 (TP53) Gene and Left Main Coronary Artery Disease.

Abstract:

:Patients with left main (LM) coronary artery disease (CAD) are at the highest risk of cardiovascular events. We evaluated possible gene polymorphisms of tumor protein 53 ( TP53, rs1042522, p.Arg72Pro) that can differentiate LM-CAD from patients with more peripheral CAD (MP-CAD) and healthy participants (control group) in 520 individuals (LM-CAD, n = 175; MP-CAD, n = 185; and control group, n = 160). Patients with LM-CAD had the lowest Arg/Arg genotype frequency (36.0%) compared with the MP-CAD (57.3%) and control groups (61.9%), P < .001 for both comparisons. Similarly, the Arg allele was more frequent in the control group than in patients with MP-CAD (78.8% vs 73.2%; P = .007) and LM-CAD (78.8% vs 64.0%; P < .001). The Arg/Pro genotype was more frequent in the LM-CAD group compared with the MP-CAD and control groups (56.0, 31.9, and 33.8, respectively, P < .001 for both comparisons). Furthermore, the frequency of Arg/Arg genotypes was the lowest in the LM-CAD group compared with the MP-CAD and control groups. Knowing that TP53 is an antioncogene protein that acts as a tumor suppressor and regulator of apoptosis, the lowest frequency of Arg/Arg genotype observed in these high-risk patients may indicate lower protection from the atherosclerosis process. Replication studies are needed to evaluate this association.

journal_name

Angiology

journal_title

Angiology

authors

Kolovou V,Tsipis A,Mihas C,Katsiki N,Vartela V,Koutelou M,Manolopoulou D,Leondiadis E,Iakovou I,Mavrogieni S,Kolovou G

doi

10.1177/0003319718760075

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

730-735

issue

8

eissn

0003-3197

issn

1940-1574

journal_volume

69

pub_type

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