Prognostic improvement by multidisciplinary therapy in patients with critical limb ischemia.

Abstract:

:Although limb salvage rate has improved in critical limb ischemia (CLI), an improvement in CLI prognosis has been scarcely reported. Multidisciplinary therapy (MT) including revascularization, wound bed preparation, treatment of comorbidity, and education of patients with CLI may improve prognosis. The aim of this study was to investigate the effectiveness of MT in prognostic improvement. We retrospectively analyzed 72 patients with CLI and assessed whether MT improved prognosis. The incidence of amputation-free survival (freedom from major amputation [MA] and death) was significantly different between the MT and conventional groups at 2 years (0% vs 33%; P = .024). After multivariate analysis, transfusion (hazard ratio [HR] 5.778; 95% confidence interval [CI], 2.372-14.073; P < .001), multivessel coronary disease (HR 3.353; 95% CI, 1.309-8.590; P = .012), and C-reactive protein >5 mg/dL (HR 3.958; 95% CI, 1.359-11.531; P = .012) were independent predictors for MA or death. We concluded that MT was effective in improved mortality and limb salvage rate.

journal_name

Angiology

journal_title

Angiology

authors

Hioki H,Miyashita Y,Miura T,Ebisawa S,Motoki H,Izawa A,Tomita T,Koyama J,Ikeda U

doi

10.1177/0003319714523113

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

187-94

issue

2

eissn

0003-3197

issn

1940-1574

pii

0003319714523113

journal_volume

66

pub_type

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