Prognostic improvement by multidisciplinary therapy in patients with critical limb ischemia.


:Although limb salvage rate has improved in critical limb ischemia (CLI), an improvement in CLI prognosis has been scarcely reported. Multidisciplinary therapy (MT) including revascularization, wound bed preparation, treatment of comorbidity, and education of patients with CLI may improve prognosis. The aim of this study was to investigate the effectiveness of MT in prognostic improvement. We retrospectively analyzed 72 patients with CLI and assessed whether MT improved prognosis. The incidence of amputation-free survival (freedom from major amputation [MA] and death) was significantly different between the MT and conventional groups at 2 years (0% vs 33%; P = .024). After multivariate analysis, transfusion (hazard ratio [HR] 5.778; 95% confidence interval [CI], 2.372-14.073; P < .001), multivessel coronary disease (HR 3.353; 95% CI, 1.309-8.590; P = .012), and C-reactive protein >5 mg/dL (HR 3.958; 95% CI, 1.359-11.531; P = .012) were independent predictors for MA or death. We concluded that MT was effective in improved mortality and limb salvage rate.






Hioki H,Miyashita Y,Miura T,Ebisawa S,Motoki H,Izawa A,Tomita T,Koyama J,Ikeda U




Has Abstract


2015-02-01 00:00:00














  • Doppler ultrasound in the evaluation of the peripheral arterial circulation.

    abstract::This review summarizes the principle, advantages, and limitations of Doppler ultrasound flowmeters, and discusses the possibilities of applying these systems in evaluating the functional state of the peripheral arterial circulation. This discussion is not limited to the assessment of blood flow velocity and poststenot...


    pub_type: 杂志文章,评审


    authors: Reneman RS,Hoeks A,Spencer MP

    更新日期:1979-08-01 00:00:00

  • Double-blind, crossover study of the clinical efficacy and the hemorheological effects of pentoxifylline in patients with occlusive arterial disease of the lower limbs.

    abstract::The effect of a 3 month daily administration of 800 mg pentoxifylline (Trental 400 bds) or placebo was assessed under double blind crossover design in 18 patients (12 males and 6 females) with peripheral occlusive arterial disease in respect of painfree walking distance and various hemorheological and hemostasiologica...


    pub_type: 临床试验,杂志文章


    authors: Strano A,Davi G,Avellone G,Novo S,Pinto A

    更新日期:1984-07-01 00:00:00

  • Applicability of Transcutaneous Oxygen Tension Measurement in the Assessment of Chronic Limb-Threatening Ischemia.

    abstract::Transcutaneous oxygen tension measurement (TcPO2) is widely applied for the evaluation of chronic limb-threatening ischemia (CLTI). Nevertheless, studies that focused on the clinical value of TcPO2 have shown varying results. We identified factors that potentially play a role in TcPO2 measurement variation such as pro...


    pub_type: 杂志文章


    authors: Leenstra B,Wijnand J,Verhoeven B,Koning O,Teraa M,Verhaar MC,de Borst GJ

    更新日期:2020-03-01 00:00:00

  • A non-invasive index of leg arterial perfusion pressure during walking, derived from cutaneous toe temperature.

    abstract::This article describes and evaluates a non-invasive technique for continuous monitoring of hemodynamic changes in the legs during walking. The method involves monitoring of cutaneous toe temperature. In six normal subjects we have shown that, during exercise under carefully controlled conditions, a unique steady-state...


    pub_type: 杂志文章


    authors: Baccelli G,Corbellini E,Walsh JT,Busca S,Boccaccini U,Zanchetti A

    更新日期:1985-08-01 00:00:00

  • Multiple cholesterol emboli syndrome--six cases identified through the spontaneous reporting system.

    abstract::Six cases of suspected multiple cholesterol emboli syndrome were identified by a review of reports contained in the company's records of adverse event reports. Antecedent risk factors in these reports included cardiac catheterization, thrombolytic therapy, translumbar aortography, renal arteriography, subclavian arter...


    pub_type: 杂志文章,评审


    authors: Hauben M,Norwich J,Shapiro E,Reich L,Petchel KS,Goldsmith D

    更新日期:1995-09-01 00:00:00

  • Pulmonary tuberculosis with multiple saccular aneurysms of the aorta--a case report.

    abstract::A forty-eight-year-old man presented with cavitary pulmonary tuberculosis and widening of the mediastinum. Mediastinal widening was due to multiple saccular aneurysms of the ascending aorta and the arch of the aorta. The various presentations of tubercular aortitis and the reasons for considering alternative etiology ...


    pub_type: 杂志文章


    authors: Mally A,D'Souza C,Dwivedi S,Shatapathi P

    更新日期:1990-04-01 00:00:00

  • Adipose-Derived Mesenchymal Stem Cells in the Treatment of Diabetic Foot Ulcers: A Review of Preclinical and Clinical Studies.

    abstract::This review provides an outline of the use of adipose-derived mesenchymal stem cells (AMSCs) in the treatment of diabetic foot ulcers (DFUs). A systematic search of PubMed and the Cochrane database was performed on October 2, 2019. Eighteen studies were identified (14 preclinical and 4 clinical). Studies in animal mod...


    pub_type: 杂志文章,评审


    authors: Álvaro-Afonso FJ,Sanz-Corbalán I,Lázaro-Martínez JL,Kakagia D,Papanas N

    更新日期:2020-10-01 00:00:00

  • Left Bundle Branch Block in Acute Cardiac Events: Insights From a 23-Year Registry.

    abstract::Between 1991 and 2013, we evaluated the demographics, presentations, and final diagnosis of patients hospitalized with acute cardiac events and left bundle branch block (LBBB). Of 50 992 patients, 768 (1.5%) had LBBB. Compared with non-LBBB patients, patients with LBBB were mostly older, female, diabetic, and had hype...


    pub_type: 杂志文章


    authors: Alkindi F,El-Menyar A,Al-Suwaidi J,Patel A,Gehani AA,Singh R,Albinali H,Arabi A

    更新日期:2015-10-01 00:00:00

  • Possible role of osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand as markers of plaque instability in coronary artery disease.

    abstract:UNLABELLED:Osteoprotegerin (OPG) produced by cardiovascular system raising the possibility that alterations of OPG serum levels may be associated with coronary artery disease (CAD). Our aim is to assess the possible role of serum OPG and soluble tumor necrosis factor-related apoptosis-inducing ligand (s-TRAIL) in the p...


    pub_type: 杂志文章


    authors: Shaker OG,El-Shehaby A,Nabih M

    更新日期:2010-11-01 00:00:00

  • Influence of the ultrasound contrast agent Levovist on human nailfold capillary microcirculation.

    abstract::Little is known about the behavior of ultrasound contrast microbubbles in human capillaries. The evaluation of circulatory effects of echo contrast media may bring valuable information for the interpretation of echo contrast phenomena in the human myocardium. In 12 healthy volunteers (aged 31 +/- 6.7 years; five women...


    pub_type: 杂志文章


    authors: Immer FF,Seiler AM,Aeschbacher BC,Mahler F,Saner H

    更新日期:2000-02-01 00:00:00

  • A simplified method for evaluating peripheral arterial occlusive disease in a clinical vascular laboratory.

    abstract::A relatively simple, inexpensive, and accurate procedure for the vascular laboratory evaluation of patients with suspected peripheral arterial occlusive disease is described. This method was evaluated in a series of 110 limbs in 58 patients seen in the Vascular Laboratory at the Worcester City Hospital. All patients w...


    pub_type: 杂志文章


    authors: Matesanz JM,Patwardhan N,Herrmann JB

    更新日期:1978-11-01 00:00:00

  • Headache, thrombolytic therapy, and chronic subdural hemorrhage--a case report.

    abstract::Subdural hematomas are well known but infrequent complications of thrombolytic therapy. Although these are usually associated with head trauma, the authors describe a case of a patient who received a particularly aggressive thrombolytic regimen and presented six months later with complaints of nothing more than a head...


    pub_type: 杂志文章


    authors: Nathan PE,Sonenblick D,Chakote V,Wolf R,Sacchi TJ

    更新日期:1994-01-01 00:00:00

  • Sensitive detection of myocardial contraction abnormality in chronic hemodialysis patients by ultrasonic tissue characterization with integrated backscatter.

    abstract::Since acoustic properties of the myocardium are sensitive to the myocardial structure and the contractile conditions of myocyte, the authors evaluated cardiac dysfunction based on the integrated ultrasonic backscatter in 18 hemodialysis (HD) patients (duration: 102 +/- 84 months, mean age: 57.6 +/- 9.7 years) and 11 a...


    pub_type: 杂志文章


    authors: Mizushige K,Tokudome T,Seki M,Kondo I,Hirao K,Nozaki S,Miki S,Yuasa S,Matsuo H

    更新日期:2000-03-01 00:00:00

  • Preclinical toxicology of pirmenol hydrochloride.

    abstract::Pirmenol hydrochloride (CI-845), a new orally effective antiarrhythmic agent, has undergone a comprehensive preclinical safety evaluation program. Repeated dose studies to evaluate chronic toxicity in rodents revealed few drug-related findings. A dose-related body weight gain suppression occurred in mice receiving up ...


    pub_type: 杂志文章


    authors: Martin RA,de la Iglesia FA

    更新日期:1988-03-01 00:00:00

  • Effects of direct stent implantation and conventional stent implantation on minor myocardial injury.

    abstract::Direct coronary stenting without balloon predilation has the potential benefits of a reduced risk of extended dissections, reduced fluoroscopy exposure, reduced procedural time, and potential cost savings. The purpose of the study was to compare the effects of angiographically successful direct stent implantation and ...


    pub_type: 杂志文章


    authors: Okmen E,Cam N,Sanli A,Yapici F,Uyarel H,Vural M,Ozturk R

    更新日期:2004-09-01 00:00:00

  • Quality assurance of high-dose i.v. heparin treatment exemplified by patients implanted with coronary Palmaz-Schatz stents.

    abstract::The need to standardize treatment with high-dose IV standard heparin by using activated partial thromboplastin time (APTT) reagents tested for their heparin sensitivity and by establishing a standard treatment schedule led to the development of the "Lainz concept" of heparin management. The determination of heparin se...


    pub_type: 杂志文章


    authors: Haushofer A,Halbmayer WM,Prachar H,Fischer M

    更新日期:1995-04-01 00:00:00

  • Young woman's digestive arterial occlusion--a case report and literature review.

    abstract::The authors report the observation of a 31-year-old woman who presented with total occlusion of digestive arteries and was successfully treated pharmacologically. A review of the literature shows that digestive arteries thrombosis is a rare condition in young women. Only 15 cases have been previously reported. Prognos...


    pub_type: 杂志文章,评审


    authors: Crètel E,Disdier P,Chagnaud C,Tournigand P,Harlé JR,Piette JC,Weiller PJ

    更新日期:1998-11-01 00:00:00

  • Thoracic cystic lymphangioma (cystic hygroma): a chest pain syndrome--a case report.

    abstract::Vascular malformations of the mediastinum including mediastinal lymphangioma are exceedingly rare in adults. A resected case of mediastinal cystic lymphangioma (cystic hygroma) that presented with acute onset of retrosternal chest pain is reported in a 45-year-old man. Cystic hygromas are benign cysts frequently disco...


    pub_type: 杂志文章


    authors: Daya SK,Gowda RM,Gowda MR,Khan IA

    更新日期:2004-09-01 00:00:00

  • Lower Extremity Fibromuscular Dysplasia: Clinical Manifestations, Diagnostic Testing, and Approach to Management.

    abstract::Fibromuscular dysplasia (FMD), a disease well described in the renal and cerebrovascular circulations, also manifests in the lower extremity (LE) arteries. This study reports on the clinical presentation, imaging findings, and treatment of patients with LE FMD seen at a single center. Over a 7-year span, 100 of 449 pa...


    pub_type: 杂志文章


    authors: Brinza E,Grabinski V,Durga S,O'Connor S,Yesenko SL,Kim ESH,Gornik HL

    更新日期:2017-09-01 00:00:00

  • A serial observation of coronary thrombi in vivo by a new percutaneous transluminal coronary angioscope.

    abstract::This study was undertaken to observe coronary thrombus formation serially from an antegrade perspective by means of a new thin flexible angioscope that has an inflatable balloon at the distal tip and an angulation mechanism. To test its capabilities, thrombi were induced in the left anterior descending coronary artery...


    pub_type: 杂志文章


    authors: Mizuno K,Miyamoto A,Isojima K,Kurita A,Senoo A,Arai T,Kikuchi M,Nakamura H

    更新日期:1992-02-01 00:00:00

  • Effect of intravenous naftidrofuryl on transcutaneous oxygen pressure in severe peripheral vascular disease.

    abstract::Intravenous naftidrofuryl has been shown to improve transcutaneous oxygen pressure values in patients with severe ischemia of the lower limbs who were considered unsuitable for reconstructive surgery. Although it did not alter the outcome in patients with rest pain, the clinical impression is that it afforded symptoma...


    pub_type: 杂志文章


    authors: Taggart I,Wishart GC,Cuschieri RJ,MacBain GC

    更新日期:1989-10-01 00:00:00

  • Thrombophlebitis: diagnostic techniques.

    abstract::A review of the extensive literature on the diagnosis of deep vein thrombophlebitis (DVT) is presented. DVT affects approximately 10% of all patients with superficial thrombophlebitis. Many authors have shown that the clinical finding of DVT are unreliable. Although pulmonary emboli are relatively frequent in all pati...


    pub_type: 杂志文章,评审


    authors: Painter TD

    更新日期:1980-06-01 00:00:00

  • The role of antiendothelial cell antibodies in the development and follow-up of coronary and peripheral arterial diseases.

    abstract::Occlusive lesions in the arterial endothelium are often caused by formation of intimal hyperplasia and fibrinoid necrosis. The objective of this study was to investigate the association between antiendothelial cell antibodies (AECAs) and the development of coronary artery disease (CAD) and peripheral artery disease (P...


    pub_type: 杂志文章


    authors: Aslim E,Hakki Akay T,Bastürk B,Ozkan S,Gültekin B,Ozcobanoglu S,Sirvan S,Aslamaci S

    更新日期:2008-04-01 00:00:00

  • Blood flow asymmetry in carotid occlusive disease.

    abstract::Patterns of anterior border zone (ABZ) and middle cerebral artery (MCA) cerebral blood flow (CBF) asymmetry were readily seen during both normocapnic room air (RA) and induced hypercapnic (CO2) inhalation using fluoro-methane and a multislice, high-resolution positron scanner. Wilcoxon two-sample rank testing showed s...


    pub_type: 杂志文章


    authors: Levine RL,Rozental JM,Nickles RJ

    更新日期:1992-02-01 00:00:00

  • Effects of nitroglycerin on myocardial excursions and velocities in the early hours of acute myocardial infarction.

    abstract::The effects of sublingual nitroglycerin on septal and left ventricular wall motion were determined by echocardiography in the early hours of acute myocardial infarction (MI) in 20 patients admitted via a mobile coronary care unit. Left ventricular and septal echoes were obtained in 11 patients with acute anterior MI a...


    pub_type: 杂志文章


    authors: Kounis NG,Zavras GM,Papadaki PJ,Soufras GD,Kitrou MP

    更新日期:1989-09-01 00:00:00

  • Systemic arterial compliance in patients with non obstructive cardiomyopathy (NOCM), and coronary artery disease (CAD).

    abstract::Arterial compliance had been estimated in three groups of patients: control, NOCM, and CAD, from analysis of the arterial pressure curve. In the three groups, a simple first order Winkessel model had been validated during normal and post extrasystolic beats. The measured arterial compliance depends mainly on i the dia...


    pub_type: 杂志文章


    authors: Levy BI,Babalis D,Masquet C,Slama R

    更新日期:1983-05-01 00:00:00

  • Surgical treatment of refractory venous stasis ulcer due to a severe impairment of calf muscle pump function: evaluation by air plethysmography. A case report.

    abstract::The authors encountered a forty-nine-year-old man with a lower limb ulcer refractory to intensive conservative therapy. No varicose vein was found anywhere, and the usual phlebographies and foot venous pressure measurement failed to diagnose it as a venous stasis ulcer. A direct phlebography method developed by the au...


    pub_type: 杂志文章


    authors: Sugimoto T,Okada M,Fukuoka M,Uematsu M,Yoshida M,Toyama H

    更新日期:1996-12-01 00:00:00

  • Silent coronary artery-left ventricular fistula: a disorder of the thebesian system?

    abstract::Two cases with abnormal electrocardiogram were found to have the unusual direct communication between the coronary artery and left ventricular chamber without any manifestations of the other reported coronary arterial fistula. ...


    pub_type: 杂志文章


    authors: Cha SD,Singer E,Maranhao V,Goldberg H

    更新日期:1978-02-01 00:00:00

  • Feasibility and safety of transcatheter intervention for complex patent ductus arteriosus.

    abstract::We evaluated the transcatheter intervention of complex patent ductus arteriosus (PDA) in Chinese adults. Between January 2004 and April 2008, 112 adult patients (43 males, 69 females, mean age 31 +/- 19 years) underwent intervention. Coils were used for patients with small PDA, and Amplatzer duct occluders or China-ma...


    pub_type: 杂志文章


    authors: Yang SW,Zhou YJ,Hu DY,Liu YY,Shi DM,Guo YH,Cheng WJ,Nie XM,Wang JL

    更新日期:2010-05-01 00:00:00

  • Assessment of collateral perfusion: a pharmacodynamic study with buflomedil hydrochloride.

    abstract::The aim of the study was to assess the influence of Buflomedil hydrochloride on collateral function. Ten patients with isolated superficial femoral occlusions were investigated twice by duplex sonography with measurement sites at the common femoral artery (CF) and the popliteal artery (PA). After the second scan 200 m...


    pub_type: 杂志文章


    authors: Labs KH,Eichlisberger R,Jeanneret C,Frauchiger B,Aschwanden M,Jäger KA

    更新日期:2000-04-01 00:00:00