Abstract:
:Blood viscosity (eta B) at shear rates 10 and 100s-1, plasma viscosity (eta P), hematocrit (Hct), and whole blood cholesterol (Chol) were measured in 50 patients with a history of myocardial infarction or unstable angina pectoris. Erythrocyte morphology was also studied by scanning electron microscopy to determine the proportion of nondiscocytic erythrocytes (NDE). There was a significant positive correlation between Chol and eta P (r = 0.41, P < 0.004) and a highly significant negative correlation (r = -0.69, P < 0.001) between Chol and Tk, a viscometric index of erythrocyte rigidity based on relative blood viscosity at high shear (eta B/eta P) corrected for Hct. This latter result indicates Chol reduction in this population may increase erythrocyte rigidity. Twenty-five patients with Chol values in the range 4.0-8.0 mmol/L were commenced on a standard lipid-lowering diet and after eight weeks half were also given pravastatin (40 mg daily). After thirty-two weeks Chol had fallen significantly more in the pravastatin group (28%) than in the diet only group (11%, P = 0.005). There was no change in eta P for either group but a significant increase in Tk for the pravastatin group only (P = 0.011). The change in total cholesterol (delta Chol) for each patient over thirty-two weeks was negatively correlated with both the change in the index of erythrocyte rigidity (delta Tk) (r = -0.40, P = 0.044) and the change in the proportion of nondiscocytic erythrocytes (delta NDE) (r = -0.47, P = 0.026). These data suggest that cholesterol reduction within the normolipemic range may be associated with unfavorable changes in blood rheology.
journal_name
Angiologyjournal_title
Angiologyauthors
Fawcett JP,Menkes DBdoi
10.1177/000331979404500304subject
Has Abstractpub_date
1994-03-01 00:00:00pages
199-206issue
3eissn
0003-3197issn
1940-1574journal_volume
45pub_type
杂志文章相关文献
ANGIOLOGY文献大全abstract::Non-sustained ventricular tachycardia (VT) in the late post myocardial infarction (MI) period (7-21 days) has been reported to be a predictor of sudden death. We suspected that patients with 3 beat VT on Holter monitoring in the late infarction period would demonstrate electrical instability at electrophysiologic stud...
journal_title:Angiology
pub_type: 临床试验,杂志文章
doi:10.1177/000331978503600307
更新日期:1985-03-01 00:00:00
abstract::Vasospasms in the eye are often combined with digital vasospasms, as can be diagnosed with a nailfold capillaroscopic local cooling test. In 16 patients with a history of cold hands and feet the presence of peripheral vasospasms without any underlying disease was demonstrated by means of nailfold video-capillaroscopy....
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979004100306
更新日期:1990-03-01 00:00:00
abstract::The effect of doxazosin withdrawal on normotensive subjects was examined by ambulatory blood pressure monitoring (ABPM) during twenty-four hours. Eight normotensive volunteers were treated with doxazosin for four weeks. ABPM was done the day before withdrawal and on the second and seventh days after withdrawal. The av...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979404500103
更新日期:1994-01-01 00:00:00
abstract::To study the effects of timing of data acquisition on quality of femoropopliteal magnetic resonance (MR) angiograms, the authors studied 16 healthy men, mean age 34.3 +/- 6 years, by color Doppler imaging and by phase-sensitive (PS) MR angiography. PS MR imaging was performed at 1.5T using a flow adjustable gradient (...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979004101002
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:It is widely believed that venous ulcers result from venous insufficiency related to venous valve damages. To further investigate the pathogenesis of venous ulcers, we compared the influence of oxidative stress in venous valvular tissue on stasis ulcer formation in patients with venous ulcers secondary to su...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319709343177
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To determine the role of digital photoplethysmography in screening asymptomatic patients who are susceptible for developing deep vein thrombosis. METHODS:Three hundred and thirty-seven limbs in 169 patients who were high risk for development of deep vein thrombosis were assessed by ultrasonography digital ph...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319708323494
更新日期:2009-06-01 00:00:00
abstract::We investigated the prevalence of peripheral arterial disease (PAD). Primary Care Health Centers (n = 14) in Thessaly (central Greece) recruited 436 participants, mean age 71 (50-79) years. Peripheral arterial disease was considered present if the ankle-brachial index (ABI) was <0.9 or >1.4 in at least 1 leg. Asymptom...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319712439092
更新日期:2013-02-01 00:00:00
abstract::Two hundred and eighty-four arteriograms were performed in the hands and feet 178 leprosy patients. Narrowing and tortuosity of the digital vessels, especially in the presence of bone absorption, were constant features. Digital tufts revealed signs of ischemia. However, in the presence of infection, hyperemia was a de...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331977802900103
更新日期:1978-01-01 00:00:00
abstract::The efficacy, tolerance and safety of iloprost, a stable analogue of carbaprostacyclin, were evaluated in 7 patients with peripheral arterial insufficiency at stage II of Fontaine's classification. After washout, placebo was infused intravenously for seven days, then iloprost was given by a six-hour intravenous infusi...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978904001009
更新日期:1989-10-01 00:00:00
abstract::Microalbuminuria (UAE) may be considered a marker of systemic vascular dysfunction, while pulse pressure (PP) is an indicator of the stiffness of vascular conduits. Both these parameters, together with left ventricular hypertrophy (LVH), are linked to cardiovascular morbidity in hypertensive patients. The aim of this ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970105200303
更新日期:2001-03-01 00:00:00
abstract::The serum zinc concentration was examined in 61 patients with acute myocardial infarction who were admitted within twenty-four hours after the onset. Forty-two of 61 patients were admitted within twelve hours. The zinc level fell sharply as early as within three hours after the onset. The minimum values were attained ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979004100610
更新日期:1990-06-01 00:00:00
abstract::The authors investigated the time-dependent action of atorvastatin and simvastatin on oxidative stress and cytokine levels immediately after the start of treatment. These factors play a role in endothelial dysfunction. Hyperlipidemic patients (n = 132) were assigned to treatment with 40 mg atorvastatin, 40 mg simvasta...
journal_title:Angiology
pub_type: 杂志文章,随机对照试验
doi:10.1177/000331970605700212
更新日期:2006-03-01 00:00:00
abstract::Peripheral neuropathy is often found in ischemic limbs with nondiabetic atherosclerotic peripheral vascular disease (PVD). Sensory symptoms such as burning pain are common in severely ischemic limbs, and sympathectomy has been undertaken for ischemic rest pain. The authors assessed noninvasive quantitative skin vasomo...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979804900303
更新日期:1998-03-01 00:00:00
abstract::The calcium-blocking agent nifedipine, which possesses vasodilating potency, was tested in 8 patients with peripheral arterial insufficiency. 10 mg sublingually significantly decreased systolic arm and ankle blood pressure. Neither blood flow nor local peripheral resistance in the calf and the forefoot at rest and the...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978303400106
更新日期:1983-01-01 00:00:00
abstract::We evaluated the transcatheter intervention of complex patent ductus arteriosus (PDA) in Chinese adults. Between January 2004 and April 2008, 112 adult patients (43 males, 69 females, mean age 31 +/- 19 years) underwent intervention. Coils were used for patients with small PDA, and Amplatzer duct occluders or China-ma...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319709351874
更新日期:2010-05-01 00:00:00
abstract::Chronic venous insufficiency (CVI) is a challenge to the medical profession, for clinical examination provides useful information on CVI, but it is qualitative and does not suffice, especially in patients with isolated deep venous insufficiency but without conspicuous signs of CVI. Ambulatory venous pressure (AVP) mea...
journal_title:Angiology
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::The combination of calcium channel blockers and beta blockers is more effective for the treatment of exercise-induced angina pectoris than beta blocker monotherapy. Since ischemia in exercise-induced angina is essentially preceded by an increase in heart rate, calcium channel blockers with negative chronotropic proper...
journal_title:Angiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1177/000331979905000602
更新日期:1999-06-01 00:00:00
abstract::Four instances of mediastinal wound infection occurred in 100 patients who underwent bilateral internal mammary artery (IMA) mobilization for coronary bypass. Debridement of 3--5 mm of the sternal edges was performed 6--18 days after the primary operation, and 2 patients required additional, anatomically limited debri...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331977802900403
更新日期:1978-04-01 00:00:00
abstract::Increased mean platelet volume (MPV) is associated with poor clinical outcome in patients with acute coronary syndrome. We evaluated the predictive role of MPV in young patients with acute myocardial infarction (AMI). This study includes 373 patients who presented to our hospital with AMI (group 1: 134 young patients,...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319712448834
更新日期:2013-07-01 00:00:00
abstract::A 63-year-old woman with progressive dyspnea underwent transthoracic echocardiography and was found to have a large multilobed mass in the left atrium that was attached to lateral wall. On inspection during surgery, the tumor was found to infiltrate the posterior mitral annulus and leaflet. The patient underwent surgi...
journal_title:Angiology
pub_type: 杂志文章,评审
doi:10.1177/0003319707306079
更新日期:2008-10-01 00:00:00
abstract::It has been shown that QT dispersion (QTD) increases during episodes of myocardial ischemia or infarction. However, no extensive data on the relation between the diseased coronary artery or the localization of stenosis and the QTD are available. The aim of the study was to examine the relation between QTD and diseased...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970105200106
更新日期:2001-01-01 00:00:00
abstract::We assessed the clinical echocardiograhic, hematological, and biochemical parameters in patients with dilated cardiomyopathy (DCMP) and control individuals mainly focusing on the mean platelet volume (MPV) in terms of DCMP and left ventricle (LV) thrombus formation. Consecutive patients (n = 251) with DCMP and 266 pat...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319711435146
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:Vascular intimal hyperplasia is associated with increased mortality and morbidity. The authors investigated the effects of atorvastatin on vascular intimal hyperplasia. MATERIALS AND METHODS:Rats were divided into 4 groups. Groups 1, 2, and 3 had experimental aortic injury and received intraperitoneal inj...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319708321102
更新日期:2009-06-01 00:00:00
abstract::Calcium antagonists are known to exert various effects on the kidney that might modulate their antihypertensive potential. This study evaluated the renal effects, along with the efficacy, of isradipine in two subgroups of patients with mild to moderate essential hypertension (EH), defined according to plasma renin act...
journal_title:Angiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/000331979704801107
更新日期:1997-11-01 00:00:00
abstract::The authors report a rare case of congenital Budd-Chiari syndrome in a twenty-eight-year-old male mongoloid. The patient was submitted to azygous-portal disconnection, because of the syndrome of portal hypertension supposedly due to cirrhosis of the liver. He died of hemorrhage of the liver on the third postoperative ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978803900211
更新日期:1988-02-01 00:00:00
abstract::Little is known about the behavior of ultrasound contrast microbubbles in human capillaries. The evaluation of circulatory effects of echo contrast media may bring valuable information for the interpretation of echo contrast phenomena in the human myocardium. In 12 healthy volunteers (aged 31 +/- 6.7 years; five women...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970005100205
更新日期:2000-02-01 00:00:00
abstract::Beta blockers are one of the oral agents shown to decrease cardiovascular morbidity and mortality rates in randomized, controlled trials, and hence, they are widely used for the management of many cardiovascular situations. In terms of side effects there are 3 major modes of action: (1) contraction of smooth muscles, ...
journal_title:Angiology
pub_type: 杂志文章,评审
doi:10.1177/000331970205300617
更新日期:2002-11-01 00:00:00
abstract::An enlarged superior thyroid artery with increased blood flow to a large benign adenomatous goiter was found to be the cause of a bruit in the region of the right carotid bifurcation. We have not been able to find mention of this cause for a cervical bruit in the literature. ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978403500906
更新日期:1984-09-01 00:00:00
abstract::The main blood flow velocity patterns in the LVOT and RVOT were recorded by pulsed Doppler echocardiography in 28 normal healthy cases, in two athletes, and in 85 patients with atrial septal defects, pulmonary regurgitation, tetralogy of Fallot, aortic regurgitation, mitral stenosis, aortic stenosis, mitral regurgitat...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978503600302
更新日期:1985-03-01 00:00:00
abstract::Although limb salvage rate has improved in critical limb ischemia (CLI), an improvement in CLI prognosis has been scarcely reported. Multidisciplinary therapy (MT) including revascularization, wound bed preparation, treatment of comorbidity, and education of patients with CLI may improve prognosis. The aim of this stu...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319714523113
更新日期:2015-02-01 00:00:00