Abstract:
:The calcium-blocking agent nifedipine, which possesses vasodilating potency, was tested in 8 patients with peripheral arterial insufficiency. 10 mg sublingually significantly decreased systolic arm and ankle blood pressure. Neither blood flow nor local peripheral resistance in the calf and the forefoot at rest and the calf during postischemic reactive hyperemia changed significantly. During postischemic hyperemia in the forefoot, the drug significantly reduced peak blood flow and increased local peripheral resistance. The drug-induced reduction in forefoot peak blood flow was correlated to the fall in systolic arm and ankle blood pressure. It is suggested that nifedipine may shorten the claudication distance in patients with peripheral arterial insufficiency.
journal_name
Angiologyjournal_title
Angiologyauthors
Lorentsen E,Landmark Kdoi
10.1177/000331978303400106subject
Has Abstractpub_date
1983-01-01 00:00:00pages
46-52issue
1eissn
0003-3197issn
1940-1574journal_volume
34pub_type
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