Hyperfibrinogenemia and hyperviscous plasma in hypertensive Africans.

Abstract:

:Changes in plasma fibrinogen concentrations (PFC) and relative plasma viscosity (RPV) were investigated in 61 Nigerian Africans while they were being treated for essential hypertension. The association of these hemorheologic variables with blood pressure was examined. An analogous study was done on 30 normotensive controls for comparison. The hypertensive patients had, overall, a significant increase in both PFC and RPV (p < 0.001) as compared with control values. However, 44.3% of the hypertensive patients had PFC and RPV values within the defined normal limits. This indicates that in a proportion of the hypertensives, treatment notwithstanding, PFC and RPV are altered only within the physiologic limits. Comparison of PFC and RPV with the degree of hypertension (mild: diastolic blood pressure (DBP) = 90mmHg; moderate: DBP = 91-99mmHg; severe: DBP > or = 100mmHg) showed significant stepwise increases at the moderate and severe levels as compared with the mild level of hypertension. The hyperfibrinogenemia and concomitant hyperviscous plasma observed in the present study could either play a role in the pathogenesis of the hypertension or be the consequence of the hypertension itself, at least in some patients.

journal_name

Angiology

journal_title

Angiology

authors

Reid HL,Ojogwu LI

doi

10.1177/000331979204301005

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

826-32

issue

10

eissn

0003-3197

issn

1940-1574

journal_volume

43

pub_type

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