In situ endothelin in coronary artery disease.

Abstract:

:Despite the significant advances made in the understanding and treatment of coronary artery disease much remains unclear about the pathogenesis of this complex atherothrombotic process. Atherogenesis may reflect a combination of multiple factors interacting with one another leading to coronary artery occlusion. One potential participant may be endothelin-1 (ET-1), a potent mitogenic vasoconstrictor. The presence of endothelin within saphenous veins before insertion and after removal during coronary artery bypass grafting (CABG) because of bypass closure, within internal mammary arteries before and after surgical intervention, and within native coronary artery segments resected during CABG was demonstrated immunocytochemically with an antiendothelin antibody and aminoethyl carbazole as the indicator chromogen. Increased amounts of ET-1 were observed in failed venous grafts, in damaged internal mammary artery grafts, and in vessels of the myocardium. These results suggest that ET-1 may play a significant pathophysiologic role in the evolution of coronary heart disease.

journal_name

Angiology

journal_title

Angiology

authors

Brody JI,Capuzzi DM,Fink GB

doi

10.1177/000331979604701101

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

1027-32

issue

11

eissn

0003-3197

issn

1940-1574

journal_volume

47

pub_type

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