Abstract:
:Thirty adult patients with distal, monolateral deep vein thrombosis of the lower limbs were randomly treated for sixty days either with subcutaneous Ca-Heparin or with Sulodexide, administered IM for ten days and orally for fifty days. The thrombus accretion above the knee, the venous pressures of the affected leg, the clinical symptomatology, and some laboratory coagulative tests were monitored throughout the administration period. Local tolerability of the two treatments was also evaluated. The two applied treatments evidenced a net antithrombotic activity, preventing thrombus accretion above the knee, improving with the same efficacy the venous pressures in the affected legs, and similarly reducing clinical symptoms, with a quick and statistically significant trend toward normalization. Blood fibrinogen was significantly lowered by both drugs, while only Ca-heparin yielded a prolongation of activated partial thromboplastin time. Local tolerability of treatments was better for the mainly oral Sulodexide administrations, while subcutaneous Ca-heparin often induced small, though transient, hematomas.
journal_name
Angiologyjournal_title
Angiologyauthors
Pinto A,Corrao S,Galati D,Arnone S,Licata A,Parrinello G,Maniscalchi T,Licata Gdoi
10.1177/000331979704800907subject
Has Abstractpub_date
1997-09-01 00:00:00pages
805-11issue
9eissn
0003-3197issn
1940-1574journal_volume
48pub_type
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