Abstract:
OBJECTIVE:To investigate precocious alterations in the artery wall of patients with primary antiphospholipid syndrome (APS). METHODS:We evaluated flow-mediated dilation (FMD) of the brachial artery and intima-media thickness (IMT) of carotid arteries in 16 patients and 16 healthy controls matched for age, gender, and other cardiovascular risk factors. RESULTS:FMD of the brachial artery was significantly lower in patients than in controls (6.3 +/- 5.2% vs 18.2 +/- 2.7; P < .005). IMT was similar in the 2 groups. FMD was significantly reduced in patients with anticardiolipin antibodies IgM. CONCLUSIONS:APS correlates closely with precocious atherosclerosis, and the correlation with a type of anticardiolipin antibody may be predictive of more accelerated atherosclerosis.
journal_name
Angiologyjournal_title
Angiologyauthors
Bilora F,Sartori MT,Zanon E,Campagnolo E,Arzenton M,Rossato Adoi
10.1177/0003319708315304subject
Has Abstractpub_date
2009-02-01 00:00:00pages
104-7issue
1eissn
0003-3197issn
1940-1574pii
0003319708315304journal_volume
60pub_type
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