Clinical characteristics in Japanese patients with coexistent hypertrophic cardiomyopathy and coronary vasospasm.

Abstract:

:There are only a few reports concerning coexistent hypertrophic cardiomyopathy (HCM) and vasospastic angina. Clinical characteristics in patients with both diseases have not been clarified yet. This study was designed to elucidate the relationship between chest pain and coronary vasospasm in HCM patients and to delineate clinical characteristics in patients with both HCM and coronary vasospasm. First, 36 patients with HCM underwent acetylcholine provocation test for coronary vasospasm and were divided into two groups on the basis of presence or absence of coronary vasospasm. Next, the following risk factors for coronary artery disease were compared between the two groups: hypertension, smoking, hyperlipidemia, diabetes mellitus, and hyperuricemia. Coronary vasospasm was induced in 10 (28%) of 36 patients with HCM. There were no significant differences in age and male gender between the two groups. Smoking was more prominent in HCM patients with than without coronary vasospasm (80% vs 35%, p<0.05), but there were no differences in the prevalence of other risk factors between the two groups. In conclusion, coronary vasospasm appears to play a significant role in the etiology of myocardial ischemia in Japanese patients with HCM, and smoking might be a major risk factor for coexistence of HCM and coronary vasospasm.

journal_name

Angiology

journal_title

Angiology

authors

Kodama K,Hamada M,Kazatani Y,Matsuzaki K,Murakami E,Shigematsu Y,Hiwada K

doi

10.1177/000331979804900909

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

849-55

issue

10

eissn

0003-3197

issn

1940-1574

journal_volume

49

pub_type

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