Abstract:
:Elevated plasma levels of asymmetric dimethylarginine (ADMA) are prevalent in patients with hypercholesterolemia and coronary artery disease. A total of 83 patients with hypercholesterolemia and angiographically documented mild coronary artery stenosis were randomized to rosuvastatin treatment (20 mg) or atorvastatin treatment (40 mg) once daily for 6 weeks after a 4-week dietary lead-in phase. Both statins decreased total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride levels effectively. Only rosuvastatin increased high-density lipoprotein cholesterol (HDL-C) levels. Both rosuvastatin and atorvastatin decreased plasma ADMA levels; rosuvastatin had a significantly greater effect. The reduction in ADMA levels were correlated with the reduction in TC and LDL-C levels as well as LDL-C-HDL-C ratio. Treatment with rosuvastatin or atorvastatin in patients with hyperlipidemia with mild coronary artery stenosis may lead to a decrease in ADMA levels, which may contribute to improved endothelial function.
journal_name
Angiologyjournal_title
Angiologyauthors
Kurtoglu E,Balta S,Sincer I,Altas Y,Atas H,Yilmaz M,Korkmaz H,Erdem K,Akturk E,Demirkol S,Can Cdoi
10.1177/0003319713507333subject
Has Abstractpub_date
2014-10-01 00:00:00pages
788-93issue
9eissn
0003-3197issn
1940-1574pii
0003319713507333journal_volume
65pub_type
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