Abstract:
:There is little information about coronary artery endothelial dysfunction in patients with sleep apnea. We evaluated relation between severity of sleep apnea and coronary artery endothelial dysfunction. In all, 26 patients without significant coronary stenoses were enrolled. Endothelial function was estimated by measuring coronary vasoreactivity in response to acetylcholine infusion (10(-7) mol/L) into coronary arteries. Vasoconstriction rate was defined as ([lumen diameter after isosorbide dinitrate injection - lumen diameter after acetylcholine injection]/lumen diameter after isosorbide dinitrate injection × 100). Vasoconstriction rate was calculated at each major coronary artery and the highest value was used for that patient. Overnight sleep study was performed and the apnea-hypopnea index (AHI) was calculated as the mean number of apneas and hypopneas per hour of sleep. There was significant correlation between AHI and vasoconstriction rate (P = .04). There is significant correlation between severity of sleep apnea and endothelial function of coronary arteries.
journal_name
Angiologyjournal_title
Angiologyauthors
Kadohira T,Kobayashi Y,Iwata Y,Kitahara H,Komuro Idoi
10.1177/0003319710394161subject
Has Abstractpub_date
2011-07-01 00:00:00pages
397-400issue
5eissn
0003-3197issn
1940-1574pii
0003319710394161journal_volume
62pub_type
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