The functional promoter polymorphism of the coagulation factor XII gene is not associated with peripheral arterial disease.

Abstract:

:Coagulation factor XII (FXII) plays a key role in both coagulation and fibrinolysis and has been associated with cardiovascular disease in some studies. Plasma FXIIa levels are strongly determined by a common functional polymorphism in the promoter of the FXII gene (F12-4C>T). To investigate the potential association of this polymorphism with peripheral arterial disease (PAD), we performed a case-control study including 668 patients with PAD and 762 controls participants without cardiovascular disease. F12 genotype frequencies were not significantly different between patients with PAD and control participants. After adjustment for classical risk factors, the odds ratio of carriers of a F12 -4T allele for PAD was 1.06 (95% confidence interval 0.86-1.32). F12 genotypes were associated with a modest increase of the mean-activated partial thromboplastin time but not with PAD stage or severity. We conclude that the functional F124C>T polymorphism is not associated with PAD.

journal_name

Angiology

journal_title

Angiology

authors

Yazdani-Biuki B,Krippl P,Brickmann K,Fuerst F,Langsenlehner U,Paulweber B,Pilger E,Wascher TC,Brezinschek HP,Renner W

doi

10.1177/0003319709337305

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

211-5

issue

2

eissn

0003-3197

issn

1940-1574

pii

0003319709337305

journal_volume

61

pub_type

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