Abstract:
:Coagulation factor XII (FXII) plays a key role in both coagulation and fibrinolysis and has been associated with cardiovascular disease in some studies. Plasma FXIIa levels are strongly determined by a common functional polymorphism in the promoter of the FXII gene (F12-4C>T). To investigate the potential association of this polymorphism with peripheral arterial disease (PAD), we performed a case-control study including 668 patients with PAD and 762 controls participants without cardiovascular disease. F12 genotype frequencies were not significantly different between patients with PAD and control participants. After adjustment for classical risk factors, the odds ratio of carriers of a F12 -4T allele for PAD was 1.06 (95% confidence interval 0.86-1.32). F12 genotypes were associated with a modest increase of the mean-activated partial thromboplastin time but not with PAD stage or severity. We conclude that the functional F124C>T polymorphism is not associated with PAD.
journal_name
Angiologyjournal_title
Angiologyauthors
Yazdani-Biuki B,Krippl P,Brickmann K,Fuerst F,Langsenlehner U,Paulweber B,Pilger E,Wascher TC,Brezinschek HP,Renner Wdoi
10.1177/0003319709337305subject
Has Abstractpub_date
2010-02-01 00:00:00pages
211-5issue
2eissn
0003-3197issn
1940-1574pii
0003319709337305journal_volume
61pub_type
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