Experimental cardiac hypertrophy induced by oral administration of mineralocorticoid and saline in rats.

Abstract:

:We suggest a new, easily applicable way of myocardial hypertrophy induction in rats. Forty randomized age-matched male Wistar rats were divided into 2 groups of 20 each: a control group and an orally administered fludrocortisone/salt group. Myocardial hypertrophy was estimated by measuring body weight, heart-weight-to-body-weight ratio and ventricular free wall thickness. Moderate myocardial hypertrophy without heart failure was established in fludrocortisone/salt group in 4 weeks. Our method is effective and low cost, and it provides a model of hypertrophic heart.

journal_name

Angiology

journal_title

Angiology

authors

Voucharas C,Tagarakis G,Lazou A,Triposkiadis F,Tsilimingas N

doi

10.1177/0003319711423529

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

416-9

issue

6

eissn

0003-3197

issn

1940-1574

pii

0003319711423529

journal_volume

63

pub_type

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