Adipose-Derived Mesenchymal Stem Cells in the Treatment of Diabetic Foot Ulcers: A Review of Preclinical and Clinical Studies.

Abstract:

:This review provides an outline of the use of adipose-derived mesenchymal stem cells (AMSCs) in the treatment of diabetic foot ulcers (DFUs). A systematic search of PubMed and the Cochrane database was performed on October 2, 2019. Eighteen studies were identified (14 preclinical and 4 clinical). Studies in animal models have demonstrated that AMSCs enhance diabetic wound healing, accelerate granulation tissue formation, and increase reepithelialization and neovascularization. Only 1 randomized control trial has been published so far. Patients (n = 25) with DFUs were treated using an allogeneic AMSC directly on the wound bed as a primary dressing, and improvements were found in complete wound closure in the treatment group (n = 16). Three clinical studies showed that autologous AMSC might be a safe alternative to achieve therapeutic angiogenesis in patients with diabetes and peripheral arterial disease. Based on the available evidence, AMSCs hold promise in the treatment of DFUs. However, this evidence requires confirmation by well-designed trials. Additional studies are also required to understand some issues regarding this treatment for DFUs. For example, the potential application of autologous or allogeneic AMSCs in different types of DFUs, optimal dose/infusion schedules, safety evaluations, and cost-effectiveness.

journal_name

Angiology

journal_title

Angiology

authors

Álvaro-Afonso FJ,Sanz-Corbalán I,Lázaro-Martínez JL,Kakagia D,Papanas N

doi

10.1177/0003319720939467

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

853-863

issue

9

eissn

0003-3197

issn

1940-1574

journal_volume

71

pub_type

杂志文章,评审
  • Mortality and morbidity in patients with intermittent claudication in relation to the location of the occlusive atherosclerosis in the leg.

    abstract::Mortality and morbidity from cerebrovascular and coronary arterial disease over a period of six years were studied in 224 non-diabetic patients with intermittent claudication. Patients with multiple arterial stenoses in the leg had a lower six-year survival than patients with single stenoses (55% versus 77%), with a h...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978503600508

    authors: Jonason T,Ringqvist I

    更新日期:1985-05-01 00:00:00

  • Cyclic variation of thickness in an age-related thick mitral valve observed by transthoracic echocardiography.

    abstract::The cyclic variation of thickness during the cardiac cycle in age-related degenerative mitral valve (MV) has not been reported. Transthoracic echocardiography was used to evaluate the cyclic alteration in MV thickness in 40 patients with age-related MV thickening (diastolic MV thickness > or = 4 mm, age 70 +/- 14 year...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979905000907

    authors: Mizushige K,Masugata H,Senda S,Manabe K,Sakamoto H,Kinoshita A,Sakamoto S,Matsuo H

    更新日期:1999-09-01 00:00:00

  • Beta-blocker-induced psoriasis: a rare side effect--a case report.

    abstract::Beta blockers are one of the oral agents shown to decrease cardiovascular morbidity and mortality rates in randomized, controlled trials, and hence, they are widely used for the management of many cardiovascular situations. In terms of side effects there are 3 major modes of action: (1) contraction of smooth muscles, ...

    journal_title:Angiology

    pub_type: 杂志文章,评审

    doi:10.1177/000331970205300617

    authors: Yilmaz MB,Turhan H,Akin Y,Kisacik HL,Korkmaz S

    更新日期:2002-11-01 00:00:00

  • Thromboangiitis obliterans (Buerger's disease) in women (a reevaluation).

    abstract::Thromboangiitis obliterans (TAO) is an occlusive vascular disease traditionally known to be almost exclusive to young male smokers. The disease was considered to be extremely rare in women, seen only as isolated, novel case reports in the literature. In the past decade, however, a dramatic increase in the incidence of...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979304400704

    authors: Yörükoğlu Y,Ilgit E,Zengin M,Nazliel K,Salman E,Yucel E

    更新日期:1993-07-01 00:00:00

  • Lysis block treatment: a new form of local thrombolysis.

    abstract::Lysis block treatment (LBT) is a new form of fibrinolytic therapy for deep vein thrombosis and arterial occlusion in the distal parts of the limbs. Strictly local lysis was achieved by placing a cuff around the thigh or the upper arm, inflating the cuff to a pressure of 500 mmHg ("Bier's blockade"), and giving heparin...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979404500210

    authors: Martin M,Heimig T,Fiebach BJ,Magnus L,Riedel C

    更新日期:1994-02-01 00:00:00

  • β-Blockers on Discharge From Acute Atrial Fibrillation Are Associated With Decreased Mortality and Lower Cerebrovascular Accidents in Patients With Heart Failure and Reduced Ejection Fraction.

    abstract::The benefits of β-blockers in patients with heart failure (HF) with reduced ejection fraction (HFrEF) and atrial fibrillation (AF) are controversial. The Gulf Survey of Atrial Fibrillation Events was a prospective, multinational, observational registry of consecutive patients with AF recruited from the emergency depar...

    journal_title:Angiology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/0003319717722283

    authors: Abi Khalil C,Zubaid M,Asaad N,Rashed WA,Hamad AK,Singh R,Al Suwaidi J

    更新日期:2018-04-01 00:00:00

  • Lipid target achievement among patients with very high and high cardiovascular risk in a lipid clinic.

    abstract::This was a retrospective study that assessed achievement of lipid-lowering treatment targets in the setting of a University Hospital Lipid Clinic. Low-density lipoprotein cholesterol (LDL-C) goal attainment according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP ATP III) and European Societ...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319714535073

    authors: Barkas F,Liberopoulos EN,Kostapanos MS,Liamis G,Tziallas D,Elisaf M

    更新日期:2015-04-01 00:00:00

  • Can rheologic variables be of prognostic relevance in arteriosclerotic diseases?

    abstract::The hypothesis that blood rheology is of prognostic value in patients with arteriosclerotic diseases was tested in a prospective study of 843 patients at a rehabilitation clinic. They were tested for blood serum and plasma viscosity, hematocrit, fibrinogen, red cell aggregation and deformability, erythrocyte sedimenta...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979104201204

    authors: Resch KL,Ernst E,Matrai A,Buhl M,Schlosser P,Paulsen HF

    更新日期:1991-12-01 00:00:00

  • Assessment of Arterial Stiffness in Korean Patients With Psoriasis by Cardio-Ankle Vascular Index.

    abstract::Many recent studies have suggested that psoriasis, a chronic, inflammatory, immune-mediated skin disease, is associated with increased risk of cardiovascular disease (CVD). We aimed to compare arterial stiffness in psoriasis and control patient groups using the cardio-ankle vascular index (CAVI) and to determine wheth...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319716652284

    authors: Choi BG,Kim MJ,Yang HS,Lee YW,Choe YB,Ahn KJ

    更新日期:2017-08-01 00:00:00

  • Tissue plasminogen activator release and plasminogen activator inhibitor levels in coronary artery disease.

    abstract::Unstable angina and Q wave myocardial infarction are associated with intraluminal coronary thrombosis, a process to which impaired fibrinolysis may contribute. The authors examined the extrinsic fibrinolytic system, including tissue plasminogen activator antigen, plasminogen activator inhibitor activity and antigen, a...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979104200707

    authors: Meyers DG,Haire WD,Rasmussen JK,Boyd EJ

    更新日期:1991-07-01 00:00:00

  • Microcirculatory efficacy of topical treatment with aescin + essential phospholipids gel on transcutaneous PO2 in venous insufficiency.

    abstract::A gel including aescin, essential phospholipids (EPL), and heparin (EG) has been used for many years for local treatment of venous, microcirculatory alterations (varicose veins, chronic venous insufficiency). Bruises, swelling, thrombophlebitis, and contusions are effectively treated with this compound. The aim of thi...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331970405500602

    authors: Cesarone MR,Belcaro G,Ippolito E,Ricci A,Ruffini M,Dugall M

    更新日期:2004-05-01 00:00:00

  • Impact of Serum Albumin Levels on Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndromes Treated With Percutaneous Coronary Intervention.

    abstract::Patients with acute coronary syndromes (ACSs) undergoing percutaneous coronary intervention (PCI) are at high risk of contrast-induced acute kidney injury (CI-AKI), a complication associated with poor clinical outcomes. Serum albumin (SA) levels are associated with cardiovascular mortality. We assessed the association...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319714551979

    authors: Murat SN,Kurtul A,Yarlioglues M

    更新日期:2015-09-01 00:00:00

  • Effect of oral pentoxifylline therapy on venous lower extremity ulcers due to deep venous incompetence.

    abstract::The effect of oral pentoxifylline, administered 1,200 mg/day (400 mg slow-release tablets tid) through six weeks, was studied in 10 patients with established deep venous incompetence and persisting venous ulcers. The following parameters were used for verification of the therapeutic result: venous patency (VP) and val...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978904000811

    authors: Angelides NS,Weil von der Ahe CA

    更新日期:1989-08-01 00:00:00

  • Echocardiographic determination of septal and left ventricular wall motion in the early hours of acute myocardial infarction.

    abstract::Interventricular septal and left ventricular posterior wall excursions and velocities were determined by M-mode echocardiography in the early hours of acute myocardial infarction in 43 patients. In the group with anterior infarction, including 24 patients, the systolic septal excursion (SSE), systolic septal velocity ...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978003100902

    authors: Kounis NG

    更新日期:1980-09-01 00:00:00

  • Routine 18F-2-deoxy-2-fluoro-D-glucose (18F-FDG) myocardial tomography using a normal large field of view gamma-camera.

    abstract::There is a recent need to study glucose metabolism of the heart in ischemic, as well as in "hibernating or stunned" myocardium, and compare it with that in perfusion studies. In non-positron emission tomography centers, positron imaging is possible with a standard Anger-type camera if proper collimation and adequate s...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978904001207

    authors: Höflin F,Ledermann H,Noelpp U,Weinreich R,Rösler H

    更新日期:1989-12-01 00:00:00

  • Pharmacokinetics of N-acetylprocainamide.

    abstract::Shortly after Dreyfus and his colleagues demonstrated that procainamide was metabolized by acetylation to N-acetylprocainamide (NAPA), Drayer, Reidenberg and Sevy reported that NAPA had antiarrhythmic activity in an animal model. We confirmed these findings and found that plasma levels of NAPA were high enough to warr...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:

    authors: Atkinson AJ Jr,Ruo TI

    更新日期:1986-12-01 00:00:00

  • Future/novel uses of beta blockers in clinical therapeutics.

    abstract::Beta-blocker usage in the United Kingdom centers around propranolol and oxprenolol as noncardioselective drugs, atenolol and metoprolol as cardioselective agents, and pindolol or oxprenolol when partial agonist activity is desired. Any meaningful comparison of a novel beta blocker against the established drugs must be...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978603700312

    authors: Maclean D

    更新日期:1986-03-01 00:00:00

  • Coronary wallstent implantation by the transradial artery approach. A case report.

    abstract::The authors report the implantation of two wallstents in a patient by use of the transradial artery approach. This approach for coronary wallstent implantation allows for intensive anticoagulation therapy with less risk of bleeding. ...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979704801008

    authors: Herz I,Assali A,Shor N,Solodky A,Sclarovsky S

    更新日期:1997-10-01 00:00:00

  • Treatment of the bradycardia-tachycardia syndrome with permanent demand pacing.

    abstract::The bradycardia-tachycardia syndrome (paroxysmal supraventricular tachycardia alternating with sinus bradycardia and episodes of sinus node arrest) has previously presented a complicated therapeutic dilemma when excitatory and suppressive drugs have been utilized. A patient with this syndrome successfully treated with...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331977602700406

    authors: Pittman DE

    更新日期:1976-04-01 00:00:00

  • Heparin and prostacyclin.

    abstract::Hemodialysis performed with prostacyclin (5 ng/kg/min) as a substitute for heparin was studied in 10 patients. The subjects were studied during heparin perfusion alone and during heparin perfusion together with prostacyclin. The authors investigated the effect of two heparin regimens (regimen I: 2,000 U/hr and regimen...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:

    authors: Camici M,Evangelisti L

    更新日期:1989-04-01 00:00:00

  • A study on left atrial transport function. Effect of age or left ventricular ejection fraction on left atrial storage fraction.

    abstract::Left atrial (LA) storage fraction is defined as the ratio of storage volume of the left atrium (LA) during ventricular systole to left ventricular (LV) stroke volume. To test their hypothesis that left atrial (LA) storage fraction is increased to compensate for impaired LV filling in the heart of aged subjects or with...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979404501108

    authors: Nishigaki K,Arakawa M,Miwa H,Kagawa K,Noda T,Ito Y

    更新日期:1994-11-01 00:00:00

  • Serum magnesium and potassium in acute myocardial infarction: relationship to existing beta-blockade and infarct size.

    abstract::Patients (n = 314) with acute myocardial infarction (AMI) were divided into three groups according to the time elapsed from onset of chest pain to when the first sample for determination of magnesium (s-Mg1) and potassium (s-K1) was drawn (A: hours 0-6; B: hours 6-10, and C: hours 10-24). Potassium and Mg were also me...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979304400502

    authors: Landmark K,Urdal P

    更新日期:1993-05-01 00:00:00

  • Possible role of osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand as markers of plaque instability in coronary artery disease.

    abstract:UNLABELLED:Osteoprotegerin (OPG) produced by cardiovascular system raising the possibility that alterations of OPG serum levels may be associated with coronary artery disease (CAD). Our aim is to assess the possible role of serum OPG and soluble tumor necrosis factor-related apoptosis-inducing ligand (s-TRAIL) in the p...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319710370961

    authors: Shaker OG,El-Shehaby A,Nabih M

    更新日期:2010-11-01 00:00:00

  • Cardiovascular disease and high-mobility group box 1--is a new inflammatory killer in town?

    abstract::High-mobility group box 1 (HMGB-1) is a nuclear protein physiologically involved in the maintaining of DNA structure in the nucleus. When tissue damage occurs, necrotic cells as well as inflammatory cells, once activated, release this protein in circulating blood, where it seems to exert a direct proinflammatory actio...

    journal_title:Angiology

    pub_type: 杂志文章,评审

    doi:10.1177/0003319712458032

    authors: Cirillo P,Giallauria F,Di Palma V,Maresca F,Ziviello F,Bevilacqua M,Vigorito C,Trimarco B

    更新日期:2013-07-01 00:00:00

  • Quantitative assessment of peripheral arterial obstruction in Raynaud's phenomenon: development of a predictive model of obstructive arterial cross-sectional area and validation with a Doppler blood flow study.

    abstract::The objective of this study was to develop a method for the analytical assessment of arterial obstruction in conditions of Raynaud's phenomenon capable of providing diagnostic criteria. Numerous attempts have been made to determine and quantify arterial obstruction in terms of Doppler ultrasound measurements of arteri...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331970005101202

    authors: Seitz WS,Kline HJ,McIlroy MB

    更新日期:2000-12-01 00:00:00

  • Facing Morbid Obesity: How to Approach It.

    abstract::Obesity is a major public health problem, with a prevalence of 10% to 20% in Western Europe. Morbid obesity, characterized by body mass index >40 kg/m(2), showed an increased prevalence in the last 30 years. Obesity is associated with reduced economic and social opportunities, reduced quality of life, and is a determi...

    journal_title:Angiology

    pub_type: 杂志文章,评审

    doi:10.1177/0003319715595735

    authors: Ricci MA,De Vuono S,Scavizzi M,Gentili A,Lupattelli G

    更新日期:2016-04-01 00:00:00

  • Lymph cysts or lymphocoele: a case report.

    abstract::A patient with a lymph cyst of the thigh following sulfuric acid burns of both feet is presented. It was diagnosed by percutaneous lymphangiography with Ethiodal. Omentopexy was performed with success. A complication of hernia of small intestine into the thigh was corrected by herniorraphy. Omentopexy is an excellent ...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978503601112

    authors: Fisher MM,Halpern GJ,Wilkins RM

    更新日期:1985-11-01 00:00:00

  • Analysis of Serum Endothelial Cell-Specific Molecule 1 (Endocan) Level in Type 2 Diabetes Mellitus With Acute ST-Segment Elevation Myocardial Infarction and its Correlation: A Pilot Study.

    abstract::Endothelial cell-specific molecule 1 (ESM-1; endocan) is expressed by endothelial cells, and it can be overexpressed in diabetic patients. However, little is known concerning diabetic patients with acute ST-segment elevation myocardial infarction (STEMI). Therefore, we assessed serum ESM-1 level in patients having typ...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319716634581

    authors: Qiu CR,Fu Q,Sui J,Zhang Q,Wei P,Wu Y,Zhu K,Lu Y,Wan P

    更新日期:2017-01-01 00:00:00

  • Basic fibroblast growth factor increased regional myocardial blood flow and limited infarct size of acutely infarcted myocardium in dogs.

    abstract::Basic fibroblast growth factor (bFGF), a growth factor potent in promoting angiogenesis, has been shown to reduce infarct size in experimentally induced acute myocardial infarction. However, the effect of bFGF on regional myocardial blood flow (Qm) in the acutely infarcted myocardium has not been well clarified. In 20...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979804900507

    authors: Miyataka M,Ishikawa K,Katori R

    更新日期:1998-05-01 00:00:00

  • An experimental overview of a new vasoactive drug: buflomedil HCl.

    abstract::A brief review of the pharmacology, pharmacokinetics, and metabolism of buflomedil-HCl is presented providing a pharmacologic basis for buflomedil therapy of ischemia associated with peripheral vascular disease. Buflomedil is readily absorbed in the gastrointestinal tract and has a plasma half-life of approximately 2-...

    journal_title:Angiology

    pub_type: 杂志文章,评审

    doi:10.1177/000331978103201001

    authors: Dubourg A,Scamuffa RF

    更新日期:1981-10-01 00:00:00