Effect of the Kallikrein Inhibitor Aprotinin on Myocardial Ischemia and Necrosis in Man.

Abstract:

:The effect of administration of aprotinin, a serine esterase inhibitor capable of inactivating kallikrein, on the extent and severity of acute myocardial ischemic injury and subsequent necrosis, was studied in 25 patients. Another group of 25 patients who did not receive aprotinin served as a control group.We administered 100,000 kallikrein inhibitor units (KIU) of aprotinin as a bolus dose, followed by a continuous infusion (4 ml/min) that contained 10,000 KIU/kg in 240 ml of dextrose/water solution, to all 25 patients admitted to the hospital within 30 to 60 minutes after the onset of acute myocardial ischemia.To measure the effect of aprotinin, three parameters were studied; the sum of S-T segment elevations (ΣST), the development of Q waves, and the prediction of infarct size by measuring the disappearance rate of creatine phosphokinase(MB CPK isoenzyme).The average ΣST in the treated group decreased from 40.5 ± 7.00 mv to 12.95 ±4.60 mv (P < 0.01); in contrast the control group's ΣST did not change significantly, from 54.25 ± 8.02 to 51.7 ± 6.8. Deeper Q waves evolved in the control group compared to the treated group: ΔQ (6 hours) = 1.0 ST (15 min) +1.19 (25 patients, r = 0.78); and in the treated group ΔQ (6 hours) = 0.66 ST (15min) + 0.91 (25 patients, r = 0.65) (P < 0.025).In the control group the estimated infarct size was 57.4 ± 4 CPK-gram equivalents(CPK-g-Eq). There was significantly less damage in the treated group: 19 ± 2 CPK-g-Eq (P < 0.01). Thus we conclude that aprotinin diminishes myocardial damage.

journal_name

Angiology

journal_title

Angiology

authors

Ceceña-Seldner FA,Villarreal J

doi

10.1177/000331978003100708

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

488-96

issue

7

eissn

0003-3197

issn

1940-1574

journal_volume

31

pub_type

杂志文章
  • Effect of enalapril maleate on cerebral blood flow in patients with chronic heart failure.

    abstract::The effect of enalapril on cerebral blood flow (CBF) was studied in 11 patients with chronic heart failure (NYHA II or III, dilated cardiomyopathy in 6 and old myocardial infarction in 5). CBF was evaluated by analyzing the Patlak-Plot curve obtained from radionuclide angiography with technetium-99m hexamethylpropylen...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979704800806

    authors: Kamishirado H,Inoue T,Fujito T,Kase M,Shimizu M,Sakai Y,Takayanagi K,Morooka S,Natsui S

    更新日期:1997-08-01 00:00:00

  • Noninvasive versus invasive evaluation of the extracranial circulation in patients with suspected cerebral vascular disease.

    abstract::This is the second in an ongoing series of evaluations in an attempt to find a combined system of noninvasive cerebral vascular evaluation of the extracranial circulation reliable enough so that decisions can be made, utilizing this system regarding further diagnostic studies and management. The current study evaluate...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978303400304

    authors: Alves AM,Sterensis JB

    更新日期:1983-03-01 00:00:00

  • Correlates of atherosclerosis in coronary arteries of patients undergoing angiographic evaluation.

    abstract::The correlations between lipid and lipoprotein measurements and other risk factors of coronary artery disease were evaluated in 101 men undergoing coronary angiography. Clinically significant disease was present in 75 patients, whereas 24 had no observable lesions and 2 had minimal lesions. Comparisons of individual l...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979004100704

    authors: Perez GO,Mendez AJ,Goldberg RB,Duncan R,Palomo A,DeMarchena E,Hsia SL

    更新日期:1990-07-01 00:00:00

  • Intrathrombus administration of tissue plasminogen activator in acute cerebrovascular occlusion.

    abstract::Intraarterial thrombolysis for acute cerebrovascular occlusion has achieved recanalization at a 50-90% rate. Clinical outcome has been unpredictable. The authors sought to test the hypothesis that intrathrombus administration of recombinant tissue plasminogen activator (rt-PA) would improve recanalization rate and to ...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979504600802

    authors: Frey JL,Greene KA,Khayata MH,Dean BL,Hodak JA,Spetzler RF

    更新日期:1995-08-01 00:00:00

  • Relation between postpacing T wave changes and myocardial scintigraphic characteristics in patients with ventricular demand pacemaker.

    abstract::The aim of this study was to elucidate the cause of T wave changes after ventricular pacing using thallium 201 single photon emission computed tomography (Tl-SPECT). Tl-SPECT was performed in 20 patients with sick sinus syndrome who had negative T wave after ventricular pacing and had had a ventricular demand pacemake...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979504600605

    authors: Abe M,Hamada M,Matsuoka H,Shigematsu Y,Sumimoto T,Okayama H,Kawakami H,Nakata S,Hiwada K

    更新日期:1995-06-01 00:00:00

  • Treatment of Raynaud's syndrome with adrenergic alpha-blockade with or without beta-blockade.

    abstract::In a double blind placebo-controlled cross-over trial of 24 weeks 31 patients with Raynaud's syndrome were treated with the alpha-blocker phenoxybenzamine (10-20 mg daily) and with the combination of the alpha-blocker phenoxybenzamine (10-20 mg daily) and the beta-blocker sotalol (40-80 mg daily). A favourable effect ...

    journal_title:Angiology

    pub_type: 临床试验,杂志文章

    doi:10.1177/000331978403500104

    authors: Cleophas TJ,van Lier HJ,Fennis JF,van 't Laar A

    更新日期:1984-01-01 00:00:00

  • Bilateral fistulas from the internal mammary arteries and the bronchial arteries to the pulmonary arteries--a case report.

    abstract::A 78-year-old man was admitted to hospital with heart failure and chronic bronchitis. A computed tomographic scan of the chest incidentally demonstrated bilateral abnormal vessels near the left atrium. Selective angiography showed that both internal mammary arteries and bronchial arteries communicated with the pulmona...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979804901010

    authors: Misumi I,Ueno K,Kimura Y,Hokamura Y,Yamabe H,Yasunaga T,Oguni T,Asao C

    更新日期:1998-09-01 00:00:00

  • An S.E.M. corrosion cast study on pericyte localization and role in microcirculation of skeletal muscle.

    abstract::The authors used the microcorrosion cast technique to study the localization and the role of pericytes in the microcirculation of skeletal muscle. Both fast twitch muscles, the tibialis anterior and the pectineus muscles, and a slow twitch one, the soleus muscle, were studied, because of morphological differences of t...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978503600708

    authors: Gaudio E,Pannarale L,Marinozzi G

    更新日期:1985-07-01 00:00:00

  • Coronary arteriographic findings during early hours of acute myocardial infarction: response to intracoronary injection of nitrates.

    abstract::We performed coronary arteriography and gave intracoronary injection of nitrates within 8 hours after the onset of symptoms of acute myocardial infarction in eighteen patients. Improved distal filling or patency of the total occluded coronary artery after intracoronary injection of nitrates occurred in 4 of 18 patient...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978303400807

    authors: Omote S,Yasue H,Takizawa A,Nagao M,Hyon H,Nishida S,Horie M

    更新日期:1983-08-01 00:00:00

  • Efficacy and tolerability of liposomal heparin spraygel as an add-on treatment in the management of superficial venous thrombosis.

    abstract::Superficial venous thrombosis usually resolves spontaneously in a few weeks. In most cases, treatment includes peroral analgesics or nonsteroidal anti-inflammatory drugs accompanied by the recommendation to wear elastic stockings and perform regular mild ambulation. In contrast to this "standard treatment," a recent A...

    journal_title:Angiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/0003319706297741

    authors: Katzenschlager R,Ugurlouglu A,Sipos G,Bihari I,Anyova EB,Hirschl M,Maruszynski M,Noszczyk W,Rybak Z,Cencora A

    更新日期:2007-04-01 00:00:00

  • Association between serum fetuin-A levels, carotid artery stiffness, and intima-media thickness in patients with normotensive obstructive sleep apnea syndrome.

    abstract::Increased carotid intima-media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association b...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319713497421

    authors: Akyuz A,Oran M,Alpsoy S,Mutlu LC,Akkoyun DC,Guzel S,Alp R

    更新日期:2014-08-01 00:00:00

  • Double-blind, crossover study of the clinical efficacy and the hemorheological effects of pentoxifylline in patients with occlusive arterial disease of the lower limbs.

    abstract::The effect of a 3 month daily administration of 800 mg pentoxifylline (Trental 400 bds) or placebo was assessed under double blind crossover design in 18 patients (12 males and 6 females) with peripheral occlusive arterial disease in respect of painfree walking distance and various hemorheological and hemostasiologica...

    journal_title:Angiology

    pub_type: 临床试验,杂志文章

    doi:10.1177/000331978403500709

    authors: Strano A,Davi G,Avellone G,Novo S,Pinto A

    更新日期:1984-07-01 00:00:00

  • A simplified method for evaluating peripheral arterial occlusive disease in a clinical vascular laboratory.

    abstract::A relatively simple, inexpensive, and accurate procedure for the vascular laboratory evaluation of patients with suspected peripheral arterial occlusive disease is described. This method was evaluated in a series of 110 limbs in 58 patients seen in the Vascular Laboratory at the Worcester City Hospital. All patients w...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331977802901102

    authors: Matesanz JM,Patwardhan N,Herrmann JB

    更新日期:1978-11-01 00:00:00

  • Behavior of circulating endothelin-1 in a group of patients with acute myocardial infarction.

    abstract::The aim of this study was to investigate the behavior of plasma endothelin-1 (ET-1) in 23 patients with acute myocardial infarction, complicated and uncomplicated by left ventricular failure, and treated with and without thrombolytic agents. ET-1 was measured on admission; on days 2, 3, and 5; and again on discharge. ...

    journal_title:Angiology

    pub_type: 临床试验,杂志文章

    doi:10.1177/000331979905000803

    authors: Battistelli S,Billi M,Manasse G,Vittoria A,Roviello F,Forconi S

    更新日期:1999-08-01 00:00:00

  • Lower Extremity Fibromuscular Dysplasia: Clinical Manifestations, Diagnostic Testing, and Approach to Management.

    abstract::Fibromuscular dysplasia (FMD), a disease well described in the renal and cerebrovascular circulations, also manifests in the lower extremity (LE) arteries. This study reports on the clinical presentation, imaging findings, and treatment of patients with LE FMD seen at a single center. Over a 7-year span, 100 of 449 pa...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319716682121

    authors: Brinza E,Grabinski V,Durga S,O'Connor S,Yesenko SL,Kim ESH,Gornik HL

    更新日期:2017-09-01 00:00:00

  • Effect of long-term administration of buflomedil on regional cerebral blood flow in chronic cerebral infarction.

    abstract::The influence of long-term oral administration of buflomedil on regional cerebral blood flow was investigated in 10 patients with chronic cerebral infarction and mild to moderate mental deterioration. Patients were given 150 mg buflomedil three times daily for a period of eight weeks. Regional cerebral blood flow (rCB...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978803901102

    authors: Kobayashi S,Yamaguchi S,Okada K,Kitani M,Yamashita K,Shimote K,Tsunematsu T

    更新日期:1988-11-01 00:00:00

  • Connective tissue in varicose veins.

    abstract::The collagen, elastin, total sugar, and nonscleroprotein content was evaluated in 32 samples of saphenous varicose vein and in 34 controls. A significantly lower collagen and elastin content was found in the varicose samples without correlation with the degree of pathologic broadening. Otherwise the total sugars and t...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331977903001202

    authors: Andreotti L,Cammelli D

    更新日期:1979-12-01 00:00:00

  • An experimental overview of a new vasoactive drug: buflomedil HCl.

    abstract::A brief review of the pharmacology, pharmacokinetics, and metabolism of buflomedil-HCl is presented providing a pharmacologic basis for buflomedil therapy of ischemia associated with peripheral vascular disease. Buflomedil is readily absorbed in the gastrointestinal tract and has a plasma half-life of approximately 2-...

    journal_title:Angiology

    pub_type: 杂志文章,评审

    doi:10.1177/000331978103201001

    authors: Dubourg A,Scamuffa RF

    更新日期:1981-10-01 00:00:00

  • Diagnosis of aortic dissection. Comparison of investigatory methods--case report.

    abstract::A case is presented of a patient with an acute aortic dissection, rapidly followed by thrombosis of the false channel. The classical aortoangiography failed to give adequate information, whereas newer, less invasive investigation methods gave images that finally led to the correct diagnosis. The value of these methods...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978703801109

    authors: Hitter E,Ranquin R,Mortelmans L,Parizel G

    更新日期:1987-11-01 00:00:00

  • A unique complication during coronary angiography: peripheral embolism by selective right coronary engagement--a case report.

    abstract::"Micro" and "macro" peripheral embolisms during coronary angiography have been described. In all these cases, the aorta or the left heart chambers have been the source of embolus. A patient who during coronary angiography for acute inferior myocardial infarction experienced acute embolism of the left common femoral ar...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331970105200709

    authors: Jain D,Kurz T,Katus HA,Richardt G

    更新日期:2001-07-01 00:00:00

  • QT dispersion and early arrhythmic risk during acute myocardial infarction.

    abstract::It has been suggested that QT dispersion (maximal minus minimal QT interval calculated on a standard 12-lead electrocardiogram) could reflect regional variations of ventricular repolarization and could provide a substrate for reentry ventricular arrhythmias. The present study evaluates QT dispersion in patients with a...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979905000305

    authors: Paventi S,Bevilacqua U,Parafati MA,Di Luzio E,Rossi F,Pelliccioni PR

    更新日期:1999-03-01 00:00:00

  • Bifascicular block complicating blunt cardiac injury. A case report and review of the literature.

    abstract::A thirty-five-year-old horse trainer presented to the emergency room of the authors' hospital with minimal nonpenetrating chest injury after having been kicked by a horse. No rib or sternum fractures were demonstrated. The admission ECG demonstrated a right bundle branch block and a left anterior hemiblock that were p...

    journal_title:Angiology

    pub_type: 杂志文章,评审

    doi:10.1177/000331979404501008

    authors: Pontillo D,Capezzuto A,Achilli A,Serraino L,Savelli S,Guerra R

    更新日期:1994-10-01 00:00:00

  • Outcomes and risk prediction model for peripheral arterial disease in patients with stable coronary artery disease.

    abstract::We used the National Heart, Lung, and Blood Institute Limited Access Dataset of Prevention of Events with Angiotensin-Converting Enzyme Inhibition (PEACE) Trial (n = 8290) which included patients with stable coronary artery disease (CAD) and preserved ejection fraction (>40%). We identified risk factors for the develo...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319711398650

    authors: Badheka AO,Rathod AD,Bharadwaj AS,Bhat S,Kizilbash MA,Veeranna V,Pidlaon V,Jacob S,Afonso L

    更新日期:2011-08-01 00:00:00

  • Association Between Plasma ADAMTS-9 Levels and Severity of Coronary Artery Disease.

    abstract::Genome-wide association studies have shown that a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS-9) is associated with the development of atherosclerosis. We assessed the level of ADAMTS-9 in patients with coronary artery disease (CAD) and its severity and prognosis. We selected 666 participant...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319720979238

    authors: Wei M,Pan H,Guo K

    更新日期:2020-12-14 00:00:00

  • Thromboangiitis obliterans (Buerger's disease) in women (a reevaluation).

    abstract::Thromboangiitis obliterans (TAO) is an occlusive vascular disease traditionally known to be almost exclusive to young male smokers. The disease was considered to be extremely rare in women, seen only as isolated, novel case reports in the literature. In the past decade, however, a dramatic increase in the incidence of...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331979304400704

    authors: Yörükoğlu Y,Ilgit E,Zengin M,Nazliel K,Salman E,Yucel E

    更新日期:1993-07-01 00:00:00

  • Pattern of angiomas in the Igbos of Nigeria.

    abstract::Almost all angiomas fall into three main groups--hemangioma, lymphangioma, and glomangioma. Fifty-one such angiomas were found in approximately 7500 surgical specimens examined at a central laboratory serving the Igbos of Nigeria. The youngest patient was aged 19 days and the oldest 70 years. Most patients presented i...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331977702801110

    authors: Onuigbo WI

    更新日期:1977-11-01 00:00:00

  • The Role of Statins in Preventing Contrast-Induced Acute Kidney Injury: A Narrative Review.

    abstract::The incidence of contrast-induced acute kidney injury (CI-AKI) is rising due to increased use of coronary angiography and percutaneous coronary intervention. Many agents, including statins, have been evaluated in several studies for the prevention of CI-AKI. To date, there have been 14 prospective randomized studies r...

    journal_title:Angiology

    pub_type: 杂志文章,评审

    doi:10.1177/0003319714549556

    authors: Akyuz S,Yaylak B,Altay S,Kasikcioglu H,Cam N

    更新日期:2015-09-01 00:00:00

  • Thrombophlebitis: diagnostic techniques.

    abstract::A review of the extensive literature on the diagnosis of deep vein thrombophlebitis (DVT) is presented. DVT affects approximately 10% of all patients with superficial thrombophlebitis. Many authors have shown that the clinical finding of DVT are unreliable. Although pulmonary emboli are relatively frequent in all pati...

    journal_title:Angiology

    pub_type: 杂志文章,评审

    doi:10.1177/000331978003100603

    authors: Painter TD

    更新日期:1980-06-01 00:00:00

  • Vasoactive intra-arterial therapy in peripheral occlusive arterial disease (with follow-up after 6.5 years).

    abstract::After a review of the history of intra-arterial treatment, our personal experience with a complex treatment of 900 cases of arteriopathy of the lower extremities is reported. The conservative treatment includes stopping smoking, plus diet, exercise, B and C vitamins, and administration of 1% xylocaine (lidocaine) in t...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331978003100401

    authors: van der Molen HR

    更新日期:1980-04-01 00:00:00

  • The role of antiendothelial cell antibodies in the development and follow-up of coronary and peripheral arterial diseases.

    abstract::Occlusive lesions in the arterial endothelium are often caused by formation of intimal hyperplasia and fibrinoid necrosis. The objective of this study was to investigate the association between antiendothelial cell antibodies (AECAs) and the development of coronary artery disease (CAD) and peripheral artery disease (P...

    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/0003319707304537

    authors: Aslim E,Hakki Akay T,Bastürk B,Ozkan S,Gültekin B,Ozcobanoglu S,Sirvan S,Aslamaci S

    更新日期:2008-04-01 00:00:00