The Role of Statins in Preventing Contrast-Induced Acute Kidney Injury: A Narrative Review.

Abstract:

:The incidence of contrast-induced acute kidney injury (CI-AKI) is rising due to increased use of coronary angiography and percutaneous coronary intervention. Many agents, including statins, have been evaluated in several studies for the prevention of CI-AKI. To date, there have been 14 prospective randomized studies regarding the efficacy of statins on the patient. Most of these studies and 3 recent meta-analyses have concluded that statins should be used for this purpose, even in patients with reduced low-density lipoprotein cholesterol levels. However, there are also conflicting results, most likely due to marked heterogeneity of patient characteristics, dosage and administration patterns of statins, definition of CI-AKI, and different statistical analyses. In conclusion, it is uncertain whether statins should be prescribed to prevent CI-AKI in the absence of other indications.

journal_name

Angiology

journal_title

Angiology

authors

Akyuz S,Yaylak B,Altay S,Kasikcioglu H,Cam N

doi

10.1177/0003319714549556

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

701-7

issue

8

eissn

0003-3197

issn

1940-1574

pii

0003319714549556

journal_volume

66

pub_type

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