Outcomes and risk prediction model for peripheral arterial disease in patients with stable coronary artery disease.

Abstract:

:We used the National Heart, Lung, and Blood Institute Limited Access Dataset of Prevention of Events with Angiotensin-Converting Enzyme Inhibition (PEACE) Trial (n = 8290) which included patients with stable coronary artery disease (CAD) and preserved ejection fraction (>40%). We identified risk factors for the development of critical peripheral arterial disease (PAD; those needing angioplasty, bypass grafting, or aneurysm repair) and formulated a risk score by multivariate analyses. A total of 220 patients (2.8%) developed critical PAD over a mean follow-up of 4.7 years. Significant predictors of critical PAD were history of intermittent claudication, smoking, hypertension (HTN), coronary-artery bypass grafting (CABG), diabetes, age, serum cholesterol, and body mass index (BMI). Incident critical PAD was associated with increased composite outcome of cardiovascular death, myocardial infarction, percutaneous transluminal coronary angioplasty, or CABG (hazard ratio 1.82, 95% CI 1.50-2.22, P < .001). Risk assessment using our score may identify CAD patients at risk for critical PAD events.

journal_name

Angiology

journal_title

Angiology

authors

Badheka AO,Rathod AD,Bharadwaj AS,Bhat S,Kizilbash MA,Veeranna V,Pidlaon V,Jacob S,Afonso L

doi

10.1177/0003319711398650

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

473-9

issue

6

eissn

0003-3197

issn

1940-1574

pii

62/6/473

journal_volume

62

pub_type

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