Abstract:
:We used the National Heart, Lung, and Blood Institute Limited Access Dataset of Prevention of Events with Angiotensin-Converting Enzyme Inhibition (PEACE) Trial (n = 8290) which included patients with stable coronary artery disease (CAD) and preserved ejection fraction (>40%). We identified risk factors for the development of critical peripheral arterial disease (PAD; those needing angioplasty, bypass grafting, or aneurysm repair) and formulated a risk score by multivariate analyses. A total of 220 patients (2.8%) developed critical PAD over a mean follow-up of 4.7 years. Significant predictors of critical PAD were history of intermittent claudication, smoking, hypertension (HTN), coronary-artery bypass grafting (CABG), diabetes, age, serum cholesterol, and body mass index (BMI). Incident critical PAD was associated with increased composite outcome of cardiovascular death, myocardial infarction, percutaneous transluminal coronary angioplasty, or CABG (hazard ratio 1.82, 95% CI 1.50-2.22, P < .001). Risk assessment using our score may identify CAD patients at risk for critical PAD events.
journal_name
Angiologyjournal_title
Angiologyauthors
Badheka AO,Rathod AD,Bharadwaj AS,Bhat S,Kizilbash MA,Veeranna V,Pidlaon V,Jacob S,Afonso Ldoi
10.1177/0003319711398650subject
Has Abstractpub_date
2011-08-01 00:00:00pages
473-9issue
6eissn
0003-3197issn
1940-1574pii
62/6/473journal_volume
62pub_type
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