Abstract:
:Clinical and epidemiological studies during the last 7 decades indicated that elevated low-density lipoprotein cholesterol (LDL-C) levels and reduced high-density lipoprotein cholesterol (HDL-C) levels correlate with the pathogenesis and progression of atherosclerotic lesions in the arterial wall. This observation led to the development of LDL-C-lowering drugs for the prevention and treatment of atherosclerosis, some with greater success than others. However, a body of recent clinical evidence shows that a substantial residual cardiovascular risk exists even at very low levels of LDL-C, suggesting that new therapeutic modalities are still needed for reduction of atherosclerosis morbidity and mortality. Unfortunately, HDL-C-raising drugs developed toward this goal had disappointing results thus far. Here, we critically review the literature presenting available evidence and challenges that need to be met and discuss possible new avenues for the development of novel lipid pharmacotherapeutics to reduce the burden of atherosclerosis.
journal_name
Angiologyjournal_title
Angiologyauthors
Kypreos KE,Bitzur R,Karavia EA,Xepapadaki E,Panayiotakopoulos G,Constantinou Cdoi
10.1177/0003319718779533subject
Has Abstractpub_date
2019-03-01 00:00:00pages
197-209issue
3eissn
0003-3197issn
1940-1574journal_volume
70pub_type
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