Abstract:
INTRODUCTION:Vascular intimal hyperplasia is associated with increased mortality and morbidity. The authors investigated the effects of atorvastatin on vascular intimal hyperplasia. MATERIALS AND METHODS:Rats were divided into 4 groups. Groups 1, 2, and 3 had experimental aortic injury and received intraperitoneal injection of atorvastatin, solvent, or 0.9% NaCl, respectively. Group 4 was a nonintervention (laparotomy only) control group. Animals were sacrificed after 3 weeks. Blood samples and injured aortic segment were analyzed. RESULTS:Atorvastatin administration significantly lowered total and low-density lipoprotein cholesterol levels (P = .012 and P = .001, respectively), intima-media ratio (P = .002), and intimal smooth muscle cell accumulation (P < .05) in group 1. Luminal narrowing in animals in group 1 was significantly lower than that in animals in groups 2 and 3, but was higher than in animals in group 4 (P = .009). CONCLUSIONS:Atorvastatin suppresses intimal hyerplasia and aids in intimal regeneration by lowering blood lipids and intimal smooth muscle cell accumulation.
journal_name
Angiologyjournal_title
Angiologyauthors
Aydin U,Ugurlucan M,Gungor F,Ziyade S,Inan B,Banach M,Kalko Y,Yasar Tdoi
10.1177/0003319708321102subject
Has Abstractpub_date
2009-06-01 00:00:00pages
370-7issue
3eissn
0003-3197issn
1940-1574pii
0003319708321102journal_volume
60pub_type
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