Different effects of beta-1-adrenergic blocking agents with ISA or without ISA on peripheral blood flow.

Abstract:

:Until recently beta-adrenergic blocking agents were considered contraindicated in peripheral arterial occlusive disease (PAOD). However, in recent years several studies have failed to show negative effects on peripheral blood flow. It was the aim of this study to compare the effects of celiprolol, a beta-1-adrenergic blocking agent with intrinsic sympathomimetic activity (ISA), and of metoprolol, a beta-1-adrenergic blocking agent without ISA, on peripheral blood flow of patients with and without PAOD. In an acute trial 24 patients (group I: 12 patients with PAOD stage I and II; group II: 12 patients without PAOD received a single dose of 200 mg celiprolol or 200 mg metoprolol in a double-blind crossover design. Celiprolol induced no significant changes in calf and skin blood flow at rest or during reactive hyperemia. Basal vascular resistance (BVR) and minimal vascular resistance (MVR) were not affected. Metoprolol, however, significantly reduced muscle blood flow and increased BVR in both groups. Subsequently the patients were treated in a randomized double-blind design with a daily dose of 200 mg celiprolol or metoprolol for three weeks. In long-term treatment skin and muscle blood flow at rest and during reactive hyperemia, BVR, and MVR were not affected by celiprolol. Metoprolol significantly lowered calf blood flow at rest in patients with PAOD; other parameters remained unchanged. In patients without PAOD, metoprolol caused a significant decrease of calf blood flow at rest and an increase of BVR. Calf blood flow during reactive hyperemia, as well as skin blood flow at rest and during reactive hyperemia, showed no significant changes.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Angiology

journal_title

Angiology

authors

Karnik R,Valentin A,Slany J

doi

10.1177/000331978703800403

subject

Has Abstract

pub_date

1987-04-01 00:00:00

pages

296-303

issue

4

eissn

0003-3197

issn

1940-1574

journal_volume

38

pub_type

临床试验,杂志文章,随机对照试验
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    journal_title:Angiology

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    doi:10.1177/000331979104200406

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  • Study of the value of corrected ejection fraction in the evaluation of left ventricular function in patients with mitral or aortic regurgitation.

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    journal_title:Angiology

    pub_type: 杂志文章

    doi:10.1177/000331970005100704

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  • Physical activity and cardiovascular disease prevention: current recommendations.

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    journal_title:Angiology

    pub_type: 杂志文章,评审

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    更新日期:2008-04-01 00:00:00

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    journal_title:Angiology

    pub_type: 杂志文章

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    pub_type: 杂志文章

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    authors: Umeki S,Terao A,Sawayama T

    更新日期:1988-01-01 00:00:00

  • Paraumbilical vein aneurysm. Case reports.

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    journal_title:Angiology

    pub_type: 杂志文章

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    更新日期:1996-05-01 00:00:00

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    pub_type: 杂志文章

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    authors: Badger SA,O'Donnell ME,Sharif MA,McMaster C,Young IS,Soong CV

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    journal_title:Angiology

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    pub_type: 杂志文章,随机对照试验

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    更新日期:1995-09-01 00:00:00

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  • Treatment of vascular inner ear disease with pentoxifylline: a 4-week, controlled, randomized trial.

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    journal_title:Angiology

    pub_type: 临床试验,杂志文章,随机对照试验

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