Abstract:
:We sought to noninvasively assess the relationship between arterial remodeling, endothelial shear stress (ESS), and wall stiffness in coronary arteries. We studied 28 coronary arteries from 22 patients undergoing coronary computed tomography angiography (CCTA). The ESS was calculated in 2-mm long segments using computational fluid dynamics. Local remodeling, plaque dimensions, and local wall stiffness were assessed in each segment. The ESS was lower in the regions of excessive expansive remodeling versus compensatory expansive versus inadequate expansive versus constrictive remodeling. Areas of decreased wall stiffness more frequently exhibited excessive expansive remodeling. Plaque volume was higher in segments showing excessive expansive and inadequate remodeling than segments with constrictive remodeling. In conclusion, CCTA enables the noninvasive assessment of coronary hemodynamics and arterial/plaque morphology. Excessive expansive remodeling is associated with high-risk plaque features, such as low ESS, decreased plaque stiffness, and increased plaque volume. This methodology may be useful in the risk assessment of individual coronary lesions.
journal_name
Angiologyjournal_title
Angiologyauthors
Katranas SA,Kelekis AL,Antoniadis AP,Chatzizisis YS,Giannoglou GDdoi
10.1177/0003319713483543subject
Has Abstractpub_date
2014-05-01 00:00:00pages
413-9issue
5eissn
0003-3197issn
1940-1574pii
0003319713483543journal_volume
65pub_type
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