Endocan Levels and Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus.

Abstract:

:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology. A major cause of morbidity and mortality in SLE is accelerated atherosclerosis. Endothelial-specific molecule 1 (endocan) is a potential predictor of vascular events and is expressed in response to inflammatory cytokines in endothelial cells. We investigated the relationship between endocan and carotid intima-media thickness (cIMT) as a marker of early atherosclerosis. We included 44 women with SLE and 44 healthy women as controls. Disease severity of SLE was evaluated using the SLE Disease Activity Index. Endocan, C-reactive protein, erythrocyte sedimentation rate (ESR), and lipid panel were measured. The cIMT was 0.70 (range: 0.45-1.20) mm in patients with SLE and 0.40 (0.25-0.60) mm in controls (P < .001). Endocan value was 1.6 ± 0.9 ng/mL in controls and 2.2 ± 1.0 ng/mL in patients with SLE (P = .014). Endocan levels were positively correlated with cIMT (r = .469, P < .001), body mass index (r = .373, P = .013), and ESR (r = .393, P = .008). Endocan level may be associated with subclinical atherosclerosis in SLE. Consequently, endocan levels may be a promising clinical tool for patients with SLE as a guide for preventive strategy.

journal_name

Angiology

journal_title

Angiology

authors

Icli A,Cure E,Cure MC,Uslu AU,Balta S,Mikhailidis DP,Ozturk C,Arslan S,Sakız D,Sahin M,Kucuk A

doi

10.1177/0003319715616240

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

749-55

issue

8

eissn

0003-3197

issn

1940-1574

pii

0003319715616240

journal_volume

67

pub_type

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