Doxazosin withdrawal and ambulatory blood pressure monitoring in normotensive subjects.

Abstract:

:The effect of doxazosin withdrawal on normotensive subjects was examined by ambulatory blood pressure monitoring (ABPM) during twenty-four hours. Eight normotensive volunteers were treated with doxazosin for four weeks. ABPM was done the day before withdrawal and on the second and seventh days after withdrawal. The average systolic and diastolic BP were not altered by doxazosin withdrawal either on day 2 or day 7, but pulse rate (PR) decreased on day 2 and day 7. Daytime PR decreased on day 2, but both daytime and nighttime PR decreased on day 7. On withdrawal of doxazosin, the plasma norepinephrine concentration decreased and the plasma renin activity tended to decrease. Neither overshooting hypertension nor cardiovascular event was related to doxazosin withdrawal was observed. It is concluded that, in normotensive subjects, discontinuation of doxazosin may result in bradycardia without hypotension or signs of withdrawal syndrome.

journal_name

Angiology

journal_title

Angiology

authors

Takata Y,Yoshizumi T,Ito Y,Hirota Y,Fujishima M

doi

10.1177/000331979404500103

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

17-23

issue

1

eissn

0003-3197

issn

1940-1574

journal_volume

45

pub_type

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