Abstract:
:Heterozygous familial hypercholesterolemia (HeFH) is a common genetic disorder predisposing affected individuals to lifelong low-density lipoprotein cholesterol (LDL-C) elevation and coronary heart disease. However, whether HeFH increases the risk of peripheral arterial disease (PAD) and ischemic stroke is undetermined. We examined associations between HeFH and these outcomes in a comprehensive systematic review and meta-analysis. We searched MEDLINE, EMBASE, Global Health, the Cochrane Library, and PubMed (for ahead-of-print publications) for relevant English-language studies. Maximally adjusted risk estimates were pooled under random- and fixed-effects meta-analysis to derive odds ratios (ORs) and 95% confidence intervals (CIs). We included 6 studies representing 183 388 participants. Heterozygnous familial hypercholesterolemia was associated with a higher risk of PAD (OR: 3.59 [95% CI: 1.30-9.89]). This trend was nonsignificantly preserved (OR: 2.96 [95% CI: 0.68-12.88]) in sensitivity analyses of genetically defined HeFH. Genetic HeFH was not associated with increased ischemic stroke risk (OR: 0.76 [95% CI: 0.37-1.58]) although possessing an LDL-C >4.9 mmol/L (190 mg/dL) was (OR: 1.42 [95% CI: 1.06-1.89]). We found clinical and genetic diagnoses of HeFH to be associated with increased PAD risk. Genetically confirmed HeFH may not confer an increased risk of ischemic stroke. Modest associations may exist between LDL-C and ischemic stroke risk in HeFH.
journal_name
Angiologyjournal_title
Angiologyauthors
Akioyamen LE,Tu JV,Genest J,Ko DT,Coutin AJS,Shan SD,Chu Adoi
10.1177/0003319719835433subject
Has Abstractpub_date
2019-09-01 00:00:00pages
726-736issue
8eissn
0003-3197issn
1940-1574journal_volume
70pub_type
杂志文章,meta分析相关文献
ANGIOLOGY文献大全abstract::The objective of this study was to determine the degree of vascular atherosclerotic damage at the carotid and femoral levels in a group of subjects over sixty years old practicing endurance sports. Using high-resolution Doppler-color flow ultrasonography the authors carried out a vascular screening, comparing two dist...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979704800709
更新日期:1997-07-01 00:00:00
abstract::Seventeen patients with heart diseases examined by left ventricular angiography were divided into two groups consisting of those with a clinical history of heart failure (CHF+) and those without (CHF-). Changes in hemodynamics, circulating blood volume, and plasma volume due to injection of the contrast medium were st...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978703801104
更新日期:1987-11-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology. A major cause of morbidity and mortality in SLE is accelerated atherosclerosis. Endothelial-specific molecule 1 (endocan) is a potential predictor of vascular events and is expressed in response to inflammatory cytokines in endothe...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319715616240
更新日期:2016-09-01 00:00:00
abstract::Increased carotid intima-media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association b...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319713497421
更新日期:2014-08-01 00:00:00
abstract::Patients with acute coronary syndromes (ACSs) undergoing percutaneous coronary intervention (PCI) are at high risk of contrast-induced acute kidney injury (CI-AKI), a complication associated with poor clinical outcomes. Serum albumin (SA) levels are associated with cardiovascular mortality. We assessed the association...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319714551979
更新日期:2015-09-01 00:00:00
abstract::Both essential hypertension (EH) and type 2 diabetes mellitus (T2DM) can impair the elasticity of the ascending aorta. We prospectively enrolled 42 patients with T2DM, 44 patients with EH, 45 patients with T2DM and EH (T2DM + EH), and 41 healthy subjects (HS). They all underwent transthoracic echocardiography to measu...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319720911572
更新日期:2020-07-01 00:00:00
abstract::The purpose of this study was the examination of short-term changes in soft-tissue water under in vivo conditions. In 12 healthy volunteers the water distribution of a selected slice of the lower limb was examined after change of position and rapid infusion of 0.9% saline solution. Two methods were used for data acqui...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979304401107
更新日期:1993-11-01 00:00:00
abstract::Six cases of coronary artery fistulae surgically treated are presented. All patient but one was male; the ages varied from 4 to 44 years. The fistulae originated from the left coronary artery in three cases from the right in two cases and from both arteries in one case. The draining heart chambers were the right atriu...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331977602701108
更新日期:1976-11-01 00:00:00
abstract::Information is lacking about the prevalence of, and the best method of preventing deep venous thrombosis (DVT) of the lower extremities in patients forty years or older with pulmonary disease that keeps them in bed for three consecutive days or more and who are thus at high risk of developing DVT or pulmonary embolism...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978803900603
更新日期:1988-06-01 00:00:00
abstract::The objective of this study was to determine the proportion of Greek patients referred to outpatient clinics for dyslipidemia who achieved the low-density lipoprotein cholesterol (LDL-C) goal defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) guidelines, using lifestyle chan...
journal_title:Angiology
pub_type: 杂志文章,多中心研究
doi:10.1177/000331970505600611
更新日期:2005-11-01 00:00:00
abstract::The hypothesis that blood rheology is of prognostic value in patients with arteriosclerotic diseases was tested in a prospective study of 843 patients at a rehabilitation clinic. They were tested for blood serum and plasma viscosity, hematocrit, fibrinogen, red cell aggregation and deformability, erythrocyte sedimenta...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979104201204
更新日期:1991-12-01 00:00:00
abstract::Two cases with abnormal electrocardiogram were found to have the unusual direct communication between the coronary artery and left ventricular chamber without any manifestations of the other reported coronary arterial fistula. ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331977802900211
更新日期:1978-02-01 00:00:00
abstract::Thirty adult patients with distal, monolateral deep vein thrombosis of the lower limbs were randomly treated for sixty days either with subcutaneous Ca-Heparin or with Sulodexide, administered IM for ten days and orally for fifty days. The thrombus accretion above the knee, the venous pressures of the affected leg, th...
journal_title:Angiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/000331979704800907
更新日期:1997-09-01 00:00:00
abstract::Procoagulant and prothrombotic states in patients with chronic atrial fibrillation (AF) are higher than those in patients with normal sinus rhythm. We assessed and compared serum γ-glutamyltranferase (GGT) activity in elderly patients with nonvalvular AF and control participants with normal sinus rhythm. Consecutive p...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319712438956
更新日期:2013-02-01 00:00:00
abstract::In a previous double-blind, randomized study, CLS 2210 (a new formulation of calcium dobesilate) or placebo was administered by intravenous infusion to 41 patients having their first acute myocardial infarction. In the present study 19 comparable patients were treated intravenously with streptokinase under identical c...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979204300904
更新日期:1992-09-01 00:00:00
abstract::A case is presented of a patient with an acute aortic dissection, rapidly followed by thrombosis of the false channel. The classical aortoangiography failed to give adequate information, whereas newer, less invasive investigation methods gave images that finally led to the correct diagnosis. The value of these methods...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978703801109
更新日期:1987-11-01 00:00:00
abstract::The value of digital systolic blood pressure (DBP) and flow (DBF) measurements for a quantitative diagnosis of Primary Raynaud's Phenomenon (PRP) was evaluated by comparing the results obtained in 10 patients and 20 normals. Digital skin temperature (DST), DBP and brachial systolic blood pressure (BBP) and DBF were me...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978603700307
更新日期:1986-03-01 00:00:00
abstract::The aim of this study was to elucidate the cause of T wave changes after ventricular pacing using thallium 201 single photon emission computed tomography (Tl-SPECT). Tl-SPECT was performed in 20 patients with sick sinus syndrome who had negative T wave after ventricular pacing and had had a ventricular demand pacemake...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979504600605
更新日期:1995-06-01 00:00:00
abstract:PURPOSE:To evaluate the prevalence of significant coronary artery disease (CAD) and nondiagnostic studies in patients referred for clinically indicated coronary angiography performed by 128 multidetector computed tomography (MDCT). METHODS:We examined patients referred for coronary computed tomography (CT) angiography...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319709335513
更新日期:2010-02-01 00:00:00
abstract::Serum gamma-glutamyltransferase (GGT) activity is a marker of oxidative stress and activity is associated with cardiovascular disease. Carotid intima-media thickness (IMT) is a noninvasive predictor of atherosclerosis. We investigated the association between serum GGT activity and carotid IMT. Fifty-five persons who h...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319710386471
更新日期:2011-02-01 00:00:00
abstract::A young Native American woman presented with ischemia of the left lower limb resulting from embolic occlusion of the left common iliac artery and left femoral artery. The source of her emboli was aortic thrombus. The only underlying abnormality responsible for her hypercoagulability appeared to be hyperhomocysteinemia...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979905000710
更新日期:1999-07-01 00:00:00
abstract::Activated protein C resistance (APC-R) is the most common inherited cause of clinically apparent venous thromboembolism. Previous data indicate that left atrial thrombus (LAT) formation is a common complication in mitral stenosis (MS) and a hypercoagulable state exists in these patients. The aim of this study was to i...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331970005101008
更新日期:2000-10-01 00:00:00
abstract::The role of carotid endarterectomy (CEA) in stroke prevention is now better defined. However, its role in patients older than 79 years of age is controversial. This group of patients has been excluded in most clinical trials. In this study the authors reviewed their experience with CEA patients >79 years old. The reco...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979804900405
更新日期:1998-04-01 00:00:00
abstract::Pirmenol hydrochloride (CI-845), a new orally effective antiarrhythmic agent, has undergone a comprehensive preclinical safety evaluation program. Repeated dose studies to evaluate chronic toxicity in rodents revealed few drug-related findings. A dose-related body weight gain suppression occurred in mice receiving up ...
journal_title:Angiology
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract::The authors studied 17 cases of symptomatic arterial fibrodysplasia involving peripheral arteries without concomitant renovascular hypertension in Iranian males (age range: twenty-two to forty-five years). Affected arteries were most commonly the femoral, iliac, and popliteal, but in 2 cases the axillary and brachial ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331978904000205
更新日期:1989-02-01 00:00:00
abstract::Endothelial cell-specific molecule 1 (ESM-1; endocan) is expressed by endothelial cells, and it can be overexpressed in diabetic patients. However, little is known concerning diabetic patients with acute ST-segment elevation myocardial infarction (STEMI). Therefore, we assessed serum ESM-1 level in patients having typ...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319716634581
更新日期:2017-01-01 00:00:00
abstract::In order to evaluate vascular wall sclerosis, the authors compared parameters of carotid pulse tracing with ascending aortic wall distensibility by using cine magnetic resonance (MR). Cine MR and carotid pulse tracing were performed in 20 healthy volunteers (mean age fifty-six years). They measured the interval from a...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979504600502
更新日期:1995-05-01 00:00:00
abstract::Fibromuscular dysplasia (FMD), a disease well described in the renal and cerebrovascular circulations, also manifests in the lower extremity (LE) arteries. This study reports on the clinical presentation, imaging findings, and treatment of patients with LE FMD seen at a single center. Over a 7-year span, 100 of 449 pa...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/0003319716682121
更新日期:2017-09-01 00:00:00
abstract::The efficacy of a new method of treatment, endovascular blood irradiation with He-Ne laser, developed by the authors, was studied in 295 patients with primary acute transmural myocardial infarction (MI). Twenty-four-hour Holter monitoring findings before and after laser irradiation suggested the possibility of prevent...
journal_title:Angiology
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract::Many nonhealing tissues are hypoxic, with oxygen tensions frequently ranging from 5 to 15 mmHg. In such an environment, the normal wound healing sequence is disrupted or halted and phagocytic killing activity depressed. So the adjunctive use of hyperbaric oxygen (HBO), based on physiologic data and clinical observatio...
journal_title:Angiology
pub_type: 杂志文章
doi:10.1177/000331979004100109
更新日期:1990-01-01 00:00:00