Abstract:
:In this association study the authors compared the insertion/deletion (I/D) angiotensin-I converting enzyme (ACE) gene polymorphism in females and males with premature myocardial infarction (MI). I/D ACE gene polymorphism was tested in 738 subjects: 302 patients with MI (151 men and 151 women) and 436 healthy subjects (207 men and 229 women). In women the ACE-DD genotype was not associated with MI (OR 1.1, 95% CI 0.6-2.1, p=0.6), whereas the ACE-DD genotype conferred a 2-fold independent risk for MI in men (95% CI=1.2-3.4; p=0.013) after adjustment for cardiovascular risk factors. The authors found evidence for the sex difference in the effect of the ACE-DD genotype on MI risk. The ACE-DD genotype conferred a 2-fold independent risk for premature MI in males.
journal_name
Angiologyjournal_title
Angiologyauthors
Petrovic D,Bregar D,Guzic-Salobir B,Skof E,Span M,Terzić R,Petrovic MG,Keber I,Letonja M,Zorc M,Podbregar M,Peterlin Bdoi
10.1177/000331970405500207subject
Has Abstractpub_date
2004-03-01 00:00:00pages
155-8issue
2eissn
0003-3197issn
1940-1574journal_volume
55pub_type
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