Occupational categories at risk for Parkinson's disease.

Abstract:

BACKGROUND:The etiology of Parkinson's disease (PD) is considered to have a strong environmental component, but relatively few studies have investigated the potential association between occupation and the disease. METHODS:In a population-based case-control study, we collected comprehensive occupational histories from all study participants, 144 case and 464 control subjects. RESULTS:Chi-square analysis revealed that working in an agricultural occupation increased estimated PD risk (OR = 1.74; 95% CI = 0.85, 3.60). In contrast, a history of ever working in a service occupation was negatively associated with PD risk (OR = 0.69; 95% CI = 0.47, 1.00). Risk estimates were close to one for specific service occupations. Adjusted odds ratios for all non-service occupational and industrial categories were similar, and working in a service occupation was the only significant inverse predictor of PD risk. CONCLUSIONS:Future investigations focusing on lifestyle factors and environmental exposures within the agricultural and service occupational categories are warranted.

journal_name

Am J Ind Med

authors

Kirkey KL,Johnson CC,Rybicki BA,Peterson EL,Kortsha GX,Gorell JM

doi

10.1002/ajim.1055

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

564-71

issue

6

eissn

0271-3586

issn

1097-0274

pii

10.1002/ajim.1055

journal_volume

39

pub_type

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