Abstract:
BACKGROUND:We evaluated the effectiveness of workplace changes to prevent indium lung disease, using 2002-2010 surveillance data collected by an indium-tin oxide production facility. METHODS:We assessed pulmonary function using lower limits of normal. Blood indium concentration and personal air sampling data were used to estimate exposure. RESULTS:Abnormalities were uncommon at hire. After hire, prevalence of spirometric restriction was 31% (n = 14/45), about fourfold higher than expected. Excessive decline in FEV1 was elevated at 29% (n = 12/41). Half (n = 21/42) had blood indium ≥5 µg/l. More recent hires had fewer abnormalities. There was a suggestion that abnormalities were more common among workers with blood indium ≥5 µg/l, but otherwise an exposure-response relationship was not evident. Peak dust concentrations were obscured by time averaging. CONCLUSIONS:Evolving lung function abnormalities consistent with subclinical indium lung disease appeared common and merit systematic investigation. Traditional measures of exposure and response were not illustrative, suggesting fresh approaches will be needed. Workplace changes seemed to have had a positive though incomplete impact; novel preventive interventions are warranted.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Cummings KJ,Suarthana E,Edwards N,Liang X,Stanton ML,Day GA,Saito R,Kreiss Kdoi
10.1002/ajim.22125subject
Has Abstractpub_date
2013-03-01 00:00:00pages
300-7issue
3eissn
0271-3586issn
1097-0274journal_volume
56pub_type
杂志文章abstract:BACKGROUND:Between 1987 and 1992, the Finnish Institute of Occupational Health (FIOH) initiated and implemented the Asbestos Program that aimed at reducing asbestos-related risks. It was a cooperative effort between government authorities, labor market organizations, and health care and labor protection personnel. MET...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20282
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:A beryllium materials manufacturer is conducting a limited pilot program that offers testing for HLA-DP beta 1E69 with genetic counseling through a third party to applicants for employment. An important consideration in this regard is the prevalence of this marker in the general population, and its consequen...
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journal_title:American journal of industrial medicine
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更新日期:2012-04-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700230104
更新日期:1993-01-01 00:00:00
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更新日期:2004-10-01 00:00:00
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更新日期:2006-01-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章,多中心研究
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更新日期:2003-01-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
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更新日期:1998-08-01 00:00:00
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更新日期:2020-11-01 00:00:00
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更新日期:2006-12-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:1987-01-01 00:00:00