Racial differences in prevalence of a supratypic HLA-genetic marker immaterial to pre-employment testing for susceptibility to chronic beryllium disease.

Abstract:

BACKGROUND:A beryllium materials manufacturer is conducting a limited pilot program that offers testing for HLA-DP beta 1E69 with genetic counseling through a third party to applicants for employment. An important consideration in this regard is the prevalence of this marker in the general population, and its consequent positive predictive value of disease susceptibility. METHODS:Polymerase chain reaction and restriction fragment length polymorphism analyses were used to determine HLA-DP beta 1E69 population frequencies. Estimation of positive predictive values assumed a disease frequency among beryllium workers of either 5 or 15% and used an odds ratio for disease risk of 35 for the HLA-DP beta 1E69 marker. RESULTS:Allelic/carrier frequencies were found to be 0.21/0.33, 0.24/0.40, 0.27/0.47, and 0.38/0.59 for Caucasians, African-Americans, Hispanics, and Chinese, respectively. Ranges of positive predictive values for a genetic test based on HLA-DP beta 1E69 in these populations were calculated to be 8.3-14.3% for carriers with an assumed disease frequency of 5%. For high risk subgroups with disease frequencies of 15%, the range of positive predictive values was found to span between 24.9-43.0%. CONCLUSIONS:These estimates suggest that using HLA-DP beta 1E69 genotyping for general pre-employment screening in the beryllium industry has a low positive predictive value, which varies little among racial groups where carrier frequencies differ significantly.

journal_name

Am J Ind Med

authors

Weston A,Ensey J,Kreiss K,Keshava C,McCanlies E

doi

10.1002/ajim.10072

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

457-65

issue

6

eissn

0271-3586

issn

1097-0274

journal_volume

41

pub_type

杂志文章
  • An approach to the characterization of silica exposure in U.S. industry.

    abstract::Quantitative evaluation of worker exposure to silica in nine Standard Industrial Classification (SIC) codes was conducted, using data derived from OSHA compliance inspections, in order to assess the silica exposure problem in the U.S. The nine SICs studied were those in which OSHA inspections were concentrated. They i...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700100403

    authors: Froines JR,Wegman DH,Dellenbaugh CA

    更新日期:1986-01-01 00:00:00

  • Lung cancer mortality among workers at a nuclear materials fabrication plant.

    abstract:BACKGROUND:The Oak Ridge, Tennessee Y-12 plant has operated as a nuclear materials fabrication plant since the 1940s. Given the work environment, and prior findings that lung cancer mortality was elevated among white male Y-12 workers relative to US white males, we investigated whether lung cancer mortality was associa...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20254

    authors: Richardson DB,Wing S

    更新日期:2006-02-01 00:00:00

  • Surveillance of pregnancy loss in human populations.

    abstract::Surveillance of pregnancy loss as a way to detect hazardous exposures is attractive in principle. However, there are no established methods for monitoring pregnancy loss in humans. Surveillance is difficult because most loss occurs within the first 12 weeks of gestation, when pregnancy may not be documented or even re...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Wilcox AJ

    更新日期:1983-01-01 00:00:00

  • Use of a prevention index to identify industries at high risk for work-related musculoskeletal disorders of the neck, back, and upper extremity in Washington state, 1990-1998.

    abstract:BACKGROUND:The prevention of work-related musculoskeletal disorders such as carpal tunnel syndrome and low back disorders has been a focus of international prevention efforts including regulation. This study examines workers compensation claims in Washington State to provide baseline data from which to assess the need ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.10054

    authors: Silverstein B,Viikari-Juntura E,Kalat J

    更新日期:2002-03-01 00:00:00

  • Autoimmune antibodies and asbestos exposure: Evidence from Wittenoom, Western Australia.

    abstract:BACKGROUND:Studies comparing different forms of asbestos are rare, and limited by the failure to compare results with unexposed populations. We compare autoimmune responses among former workers and residents of the crocidolite mining and milling town of Wittenoom, Western Australia, with an unexposed population. METHO...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22863

    authors: Reid A,Franklin P,de Klerk N,Creaney J,Brims F,Musk B,Pfau J

    更新日期:2018-07-01 00:00:00

  • Patterns and predictors of employer risk-reduction activities (ERRAs) in response to a work-related upper extremity cumulative trauma disorder (UECTD): reports from workers' compensation claimants.

    abstract:BACKGROUND:Despite being preventable, work-related upper extremity cumulative trauma disorders (UECTDs) remain problematic. This study is unique in its focus on predictors of employer risk-reduction activities (ERRAs) in response to a UECTD case. METHODS:Workers' compensation claimants (N = 537) completed a telephone ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/1097-0274(200011)38:5<489::aid-ajim1>3.0.c

    authors: Keogh JP,Gucer PW,Gordon JL,Nuwayhid I

    更新日期:2000-11-01 00:00:00

  • Occupational exposure to disinfectants and asthma incidence in U.S. nurses: A prospective cohort study.

    abstract:BACKGROUND:Exposure to disinfectants among healthcare workers has been associated with respiratory health effects, in particular, asthma. However, most studies are cross-sectional and the role of disinfectant exposures in asthma development requires longitudinal studies. We investigated the association between occupati...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.23067

    authors: Dumas O,Boggs KM,Quinot C,Varraso R,Zock JP,Henneberger PK,Speizer FE,Le Moual N,Camargo CA Jr

    更新日期:2020-01-01 00:00:00

  • Preventing falls in residential construction: Effectiveness of engaging partners for a national social marketing campaign.

    abstract:BACKGROUND:Falls are the leading cause of fatalities in construction. The Safety Pays, Falls Cost campaign aims to prevent falls in residential construction. A critical component of our social marketing approach was to involve 70 partners in reaching target audiences. METHODS:We assessed partner engagement April 2012-...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22458

    authors: Macario E,Hannon SW,Baker R,Branche CM,Trahan C

    更新日期:2015-08-01 00:00:00

  • Effectiveness of the training program for workers at construction sites of the high-speed railway line between Torino and Novara: impact on injury rates.

    abstract:BACKGROUND:There are very few published studies evaluating the impact of safety and health training on injury outcomes in the construction industry. The aim of this study was to assess the impact of the training program on injury rates at a major railway construction project. METHODS:The population consisted of 2,795 ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20770

    authors: Bena A,Berchialla P,Coffano ME,Debernardi ML,Icardi LG

    更新日期:2009-12-01 00:00:00

  • Occupational neck and shoulder pain among automobile manufacturing workers in Iran.

    abstract:BACKGROUND:Work-related musculoskeletal disorders (MSDs) of the upper extremities are a major problem globally, though most relevant studies have been reported from high income countries. AIMS AND METHODS:The prevalence of neck and shoulder pain and its association with work-related physical and psychosocial factors a...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20562

    authors: Alipour A,Ghaffari M,Shariati B,Jensen I,Vingard E

    更新日期:2008-05-01 00:00:00

  • Comparison of fatal and severe nonfatal traumatic work-related injuries in Washington state.

    abstract:OBJECTIVE:To compare fatal and hospitalized nonfatal work-related traumatic injuries by occupation and cause. METHODS:Fatal and hospitalized nonfatal injuries occurring from 1991-1995 were identified from Washington State workers' compensation claims data. Nonfatal injuries were classified as severe if they had at lea...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0274(199908)36:2<317::aid-ajim1

    authors: Alexander BH,Franklin GM,Fulton-Kehoe D

    更新日期:1999-08-01 00:00:00

  • Fluorocarbon 113 exposure and cardiac dysrhythmias among aerospace workers.

    abstract::We investigated the cardiotoxic effects of 1,1,2-Trichloro-1,2,2- Trifluoroethane (fluorocarbon 113 or FC113) exposures among healthy workers cleaning rocket and ground support equipment for the National Aeronautic and Space Administration (NASA) programs. Exposure and ambulatory electrocardiographic (ECG) monitoring ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700220607

    authors: Egeland GM,Bloom TF,Schnorr TM,Hornung RW,Suruda AJ,Wille KK

    更新日期:1992-01-01 00:00:00

  • Occupational magnetic field exposure and the risk of acoustic neuroma.

    abstract:BACKGROUND:Acoustic neuroma is the intracranial tumor subtype showing the highest relative risk in relation to ionizing radiation but other environmental risk factors are largely unknown. This study was performed to investigate the effect of power frequency magnetic fields. METHOD:A total of 793 cases between 1987 and...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20251

    authors: Forssén UM,Lönn S,Ahlbom A,Savitz DA,Feychting M

    更新日期:2006-02-01 00:00:00

  • Occupational bladder cancer mortality among racial and ethnic minorities in 21 states.

    abstract:BACKGROUND:Occupational bladder cancer mortality among minority racial/ethnic groups is not well described compared to occupational bladder cancer mortality among non-minority males in the United States. METHODS:Race/ethnicity- and sex-specific bladder cancer mortality (1985-1992) of workers employed in 21 states was ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/1097-0274(200007)38:1<90::aid-ajim10>3.0.c

    authors: Schulz MR,Loomis D

    更新日期:2000-07-01 00:00:00

  • Artificial intelligence: Implications for the future of work.

    abstract::Artificial intelligence (AI) is a broad transdisciplinary field with roots in logic, statistics, cognitive psychology, decision theory, neuroscience, linguistics, cybernetics, and computer engineering. The modern field of AI began at a small summer workshop at Dartmouth College in 1956. Since then, AI applications mad...

    journal_title:American journal of industrial medicine

    pub_type: 历史文章,杂志文章,评审

    doi:10.1002/ajim.23037

    authors: Howard J

    更新日期:2019-11-01 00:00:00

  • Estimation of the global burden of disease attributable to contaminated sharps injuries among health-care workers.

    abstract:BACKGROUND:The global burden of hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) infection due to percutaneous injuries among health care workers (HCWs) is estimated. METHODS:The incidence of infections attributable to percutaneous injuries in 14 geographical regions on the basis of the pro...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20230

    authors: Prüss-Ustün A,Rapiti E,Hutin Y

    更新日期:2005-12-01 00:00:00

  • Biomass fuel use for cooking in Sri Lanka: analysis of data from national demographic health surveys.

    abstract:BACKGROUND:Biomass cooking fuel is the main source of indoor air pollution in the majority of households in the developing world. Sri Lanka is an island of about 20 million population with urban, rural, and estate population of 14.6%, 80.0%, and 5.4%, respectively. This study describes biomass fuel use for cooking in S...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.21023

    authors: Nandasena S,Wickremasinghe AR,Sathiakumar N

    更新日期:2012-12-01 00:00:00

  • Skin symptoms in the construction industry: occurrence and determinants.

    abstract:BACKGROUND:In the construction industry, a relatively high hand eczema prevalence can be expected due to exposure to irritating and allergenic agents. METHODS:As part of a regular program of voluntary medical examinations, a questionnaire including items on health symptoms and working circumstances is administered to ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22314

    authors: Timmerman JG,Heederik D,Spee T,Smit LA

    更新日期:2014-06-01 00:00:00

  • Effect of repeated occupational exposure to lead, cessation of exposure, and chelation on levels of lead in bone.

    abstract::A sensitive K-X-ray fluorescence (K-XRF) instrument was used to measure lead levels in the tibia and patella on a series of twelve subjects who had relatively well-documented histories of lead exposure and blood lead levels. For some subjects, K-XRF measurements were taken at multiple points in time, and before and af...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700200603

    authors: Hu H,Pepper L,Goldman R

    更新日期:1991-01-01 00:00:00

  • Beryllium sensitivity among workers at a Norwegian aluminum smelter.

    abstract:BACKGROUND:Sensitivity to beryllium was investigated among workers at an aluminum smelter in Norway as a consequence of the findings in an occupational exposure survey. METHODS:Three hundred and sixty-two employees and 31 reference persons were tested for sensitization to beryllium with the beryllium lymphocyte prolif...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20816

    authors: Nilsen AM,Vik R,Behrens C,Drabløs PA,Espevik T

    更新日期:2010-07-01 00:00:00

  • The Bassett Farm Safety and Health Project.

    abstract::The Bassett Farm Safety and Health Project was started in 1980 when Drs. May and Pratt made clinical observations on respiratory illnesses in farmers. The initial work involved the investigation of clinical syndromes associated with dust exposures and, from there, environmental dust studies. The current scope of work ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700180407

    authors: Pratt DS

    更新日期:1990-01-01 00:00:00

  • A semi-quantitative job exposure matrix for dust exposures in Swedish soft tissue paper mills.

    abstract:BACKGROUND:Total paper dust exposure has been associated with respiratory problems among workers in the soft tissue paper industry. However, a comprehensive job exposure matrix (JEM) has not been developed for application to this industry. Our study was intended to address this need and to support further studies of mo...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.23090

    authors: Neitzel RL,Andersson M,Lohman S,Sällsten G,Torén K,Andersson E

    更新日期:2020-04-01 00:00:00

  • The Italian surveillance system for occupational cancers: characteristics, initial results, and future prospects.

    abstract:BACKGROUND:Occupational cancer monitoring is important for cancer prevention and public health protection. A surveillance system for identifying occupational cancer risks and cancer cases in Italy that are likely to be of occupational origin using information available in the Italian Social Security archives was create...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20356

    authors: Crosignani P,Massari S,Audisio R,Amendola P,Cavuto S,Scaburri A,Zambon P,Nedoclan G,Stracci F,Pannelli F,Vercelli M,Miligi L,Imbriani M,Berrino F

    更新日期:2006-09-01 00:00:00

  • Methodologic issues in intervention research--health care.

    abstract::To better understand the methodological challenges faced by intervention research in health care, workshops reviewed two intervention studies to reduce back injuries among nursing home staff and two studies on the use of precautions to prevent occupational transmission of bloodborne pathogens. These studies adapted ri...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0274(199604)29:4<412::AID-AJIM2

    authors: Hersey JC,Collins JW,Gershon R,Owen B

    更新日期:1996-04-01 00:00:00

  • Impact of precarious work on neighborhood health: Concept mapping by a community/academic partnership.

    abstract:OBJECTIVE:As part of community-based participatory research (CBPR) examining precarious employment and community health, academic, and community researchers used concept mapping to explore how residents in two high hardship neighborhoods perceive the impact of work on health. METHODS:Between January and May 2017, 292 ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.23055

    authors: Velonis AJ,Hebert-Beirne J,Conroy LM,Hernandez M,Castaneda D,Forst L

    更新日期:2020-01-01 00:00:00

  • Health risks posed by use of Di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review.

    abstract:BACKGROUND:Polyvinyl chloride plastics (PVC), made flexible through the addition of di-2-ethylhexyl phthalate (DEHP), are used in the production of a wide array of medical devices. From the late 1960s, leaching of DEHP from PVC medical devices and ultimate tissue deposition have been documented. METHODS:A critical rev...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,meta分析

    doi:10.1002/1097-0274(200101)39:1<100::aid-ajim10>3.0.

    authors: Tickner JA,Schettler T,Guidotti T,McCally M,Rossi M

    更新日期:2001-01-01 00:00:00

  • Injuries due to assaults on psychiatric hospital employees in Washington State.

    abstract::In order to estimate rates and identify risk factors for assaults on employees of a state psychiatric hospital, we examined workers' compensation claims, hospital-recorded incident reports, and data collected in a survey of ward staff. Results revealed 13.8 workers' compensation claims due to assault per 100 employees...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0274(199701)31:1<92::aid-ajim14

    authors: Bensley L,Nelson N,Kaufman J,Silverstein B,Kalat J,Shields JW

    更新日期:1997-01-01 00:00:00

  • Efficiency of autocoding programs for converting job descriptors into standard occupational classification (SOC) codes.

    abstract:BACKGROUND:Existing datasets often lack job exposure data. Standard Occupational Classification (SOC) codes can link work exposure data to health outcomes via a Job Exposure Matrix, but manually assigning SOC codes is laborious. We explored the utility of two SOC autocoding programs. METHODS:We entered industry and oc...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22928

    authors: Buckner-Petty S,Dale AM,Evanoff BA

    更新日期:2019-01-01 00:00:00

  • Indirect fertility analysis in painters exposed to ethylene glycol ethers: sensitivity and specificity.

    abstract::Semen analysis has proven useful in the clinical diagnosis of infertility and is the most widely used method of monitoring the effects of occupational exposure on male fertility. Collection and analysis of semen samples in a field setting, however, require a highly motivated population and excellent technical resource...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700200209

    authors: Welch LS,Plotkin E,Schrader S

    更新日期:1991-01-01 00:00:00

  • Asbestos bodies in lung tissue following exposure to crocidolite.

    abstract::A series of 206 necropsies in Western Australia (WA) have had routine counts made of asbestos bodies in samples of lung tissue using conventional light microscopy. Thirty-two cases had worked in the asbestos industry at Wittenoom, WA and (log) counts of asbestos bodies in their lung tissue correlated well with estimat...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700280405

    authors: Williams V,de Klerk NH,Whitaker D,Musk AW,Shilkin KB

    更新日期:1995-10-01 00:00:00