Life-span carcinogenicity studies on Sprague-Dawley rats exposed to γ-radiation: design of the project and report on the tumor occurrence after post-natal radiation exposure (6 weeks of age) delivered in a single acute exposure.

Abstract:

BACKGROUND:Experimental long-term carcinogenicity bioassays conducted on rats and mice proved that ionizing radiation can induce a variety of tumor types. However few studies have been conducted on rats. METHODS:This report deals with the effects of γ-radiation in groups of 416-1,051 6-weeks old Sprague-Dawley rats exposed to 0, 0.1, 1, or 3 Gy of γ-radiation delivered in a single acute exposure. The experiment lasted for the animals' lifespan and all were necropsied and underwent full histopathological evaluation. RESULTS:The results confirm the dose-related carcinogenic effects of γ-radiation for several organs and tissues. Moreover they indicate that exposure to 0.1 Gy induces a statistically significant increased incidence in Zymbal gland carcinomas and pancreas islet cell carcinomas in females. CONCLUSIONS:Our data show that exposure to γ-radiation induces carcinogenic effects at all tested doses.

journal_name

Am J Ind Med

authors

Soffritti M,Tibaldi E,Bua L,Padovani M,Falcioni L,Lauriola M,Manservigi M,Manservisi F,Belpoggi F

doi

10.1002/ajim.22391

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

46-60

issue

1

eissn

0271-3586

issn

1097-0274

journal_volume

58

pub_type

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