Abstract:
:The metabolic engineering of natural products has begun to prosper in the past few years due to genomic research and the discovery of biosynthetic genes. While the biosynthetic pathways and genes for some isoprenoids have been known for many years, new pathways have been found and known pathways have been further investigated. In this article, we review the recent advances in metabolic engineering of isoprenoids, focusing on the molecular genetics that affects pathway engineering the most. Examples in mono- sequi-, and diterpenoid synthesis as well as carotenoid production are discussed.
journal_name
Metab Engjournal_title
Metabolic engineeringauthors
Barkovich R,Liao JCdoi
10.1006/mben.2000.0168subject
Has Abstractpub_date
2001-01-01 00:00:00pages
27-39issue
1eissn
1096-7176issn
1096-7184pii
S109671760090168Xjournal_volume
3pub_type
杂志文章,评审abstract::In this study strains of Ralstonia eutropha H16 and Pseudomonas putida KT2440 were engineered which are suitable for biotechnological production of 2-methylcitric acid (2MC). Analysis of a previous mutant of R. eutropha able to accumulate 2MC recommended this strain as a candidate for fermentative production of 2MC. T...
journal_title:Metabolic engineering
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abstract::Synthesis of polyketides at high titer and yield is important for producing pharmaceuticals and biorenewable chemical precursors. In this work, we engineered cofactor and transport pathways in Saccharomyces cerevisiae to increase acetyl-CoA, an important polyketide building block. The highly regulated yeast pyruvate d...
journal_title:Metabolic engineering
pub_type: 杂志文章
doi:10.1016/j.ymben.2016.02.009
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pub_type: 杂志文章,评审
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journal_title:Metabolic engineering
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doi:10.1016/j.ymben.2005.10.001
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pub_type: 杂志文章
doi:10.1016/j.ymben.2018.11.009
更新日期:2019-03-01 00:00:00
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journal_title:Metabolic engineering
pub_type: 杂志文章
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journal_title:Metabolic engineering
pub_type: 杂志文章
doi:10.1006/mben.1999.0115
更新日期:1999-10-01 00:00:00
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journal_title:Metabolic engineering
pub_type: 杂志文章
doi:10.1016/j.ymben.2009.12.004
更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.ymben.2017.11.003
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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