Paramutation in maize.

Abstract:

:Paramutation is a heritable change in gene expression induced by allele interactions. This review summarizes key experiments on three maize loci, which undergo paramutation. Similarities and differences between the phenomenology at the three loci are described. In spite of many differences with respect to the stability of the reduced expression states at each locus or whether paramutation correlates with DNA methylation and repeated sequences within the loci, recent experiments are consistent with a common mechanism underlying paramutation at all three loci. Most strikingly, trans-acting mutants have been isolated that prevent paramutation at all three loci and lead to the activation of silenced Mutator transposable elements. Models consistent with the hypothesis that paramutation involves heritable changes in chromatin structure are presented. Several potential roles for paramutation are discussed. These include localizing recombination to low-copy sequences within the genome, establishing and maintaining chromatin domain boundaries, and providing a mechanism for plants to transmit an environmentally influenced expression state to progeny.

journal_name

Plant Mol Biol

journal_title

Plant molecular biology

authors

Chandler VL,Eggleston WB,Dorweiler JE

doi

10.1023/a:1006499808317

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

121-45

issue

2-3

eissn

0167-4412

issn

1573-5028

journal_volume

43

pub_type

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