UVB-induced acantholysis in endemic Pemphigus foliaceus (Fogo selvagem) and Pemphigus vulgaris.

Abstract:

BACKGROUND:The autoantibody-mediated disease in fogo selvagem (FS) is aggravated by sunlight exposure. OBJECTIVE:The aim of this study was to test whether UVB exposure of uninvolved skin of patients with FS (n = 21) enhances epidermal acantholysis and in vivo binding of FS autoantibodies as compared with a control group (n = 4). Another control group included 8 patients with pemphigus vulgaris (PV). RESULTS:Exposure of uninvolved skin of FS to UVB induces acantholysis (15/21 patients) with in vivo binding of IgG and C3 to the epidermal intercellular spaces (17/21 patients). Similar results were found in PV (6/8 patients). The test was negative in the control group. CONCLUSION:Sunlight exposure is harmful in the clinical course of patients with FS and those with PV. Protection from sunlight should be part of the treatment of these patients.

journal_name

J Am Acad Dermatol

authors

Reis VM,Toledo RP,Lopez A,Diaz LA,Martins JE

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

571-6

issue

4

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(00)90167-1

journal_volume

42

pub_type

杂志文章
  • Vesiculobullous lesions caused by cytomegalovirus infection in an immunocompromised adult.

    abstract::Skin involvement in cytomegalovirus (CMV) infection is very rare. Reported cutaneous manifestations are nonspecific and include petechial, purpuric, and morbilliform rashes. We describe an immunocompromised patient who developed a vesiculobullous eruption. A simple Tzanck preparation from the base of a blister reveale...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(84)70234-9

    authors: Bhawan J,Gellis S,Ucci A,Chang TW

    更新日期:1984-10-01 00:00:00

  • Action of isotretinoin in acne rosacea and gram-negative folliculitis.

    abstract::Good to excellent clinical results have been obtained in the treatment of severe inflammatory acne (acne conglobata, acne fulminans, and acne conglobata with hidradenitis and dissecting cellulitis of the scalp) with orally administered isotretinoin (13-cis-retinoic acid). Similar promising results have been obtained i...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0190-9622(82)70067-2

    authors: Plewig G,Nikolowski J,Wolff HH

    更新日期:1982-04-01 00:00:00

  • Role of intravenous immunoglobulin in the treatment of bullous pemphigoid: analysis of current data.

    abstract:BACKGROUND:Conventional therapy of severe bullous pemphigoid (BP) relies on the use of high-dose systemic corticosteroids with or without adjuvants, notably immunosuppressive agents. This approach can result in debilitating and potentially fatal side effects, hence the need to explore alternative therapies. Intravenous...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,meta分析

    doi:10.1067/mjd.2000.112288

    authors: Engineer L,Ahmed AR

    更新日期:2001-01-01 00:00:00

  • Cutaneous angiomas in POEMS syndrome.

    abstract::POEMS syndrome is an unusual plasma cell dyscrasia with multisystemic manifestations featuring polyneuropathy, organomegaly, endocrinopathy, M protein and constant skin involvement. We have seen a 58-year-old white man presenting with generalized eruptive angiomas as a rare skin manifestation of this syndrome. We revi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(85)70123-5

    authors: Puig L,Moreno A,Domingo P,Llistosella E,de Moragas JM

    更新日期:1985-05-01 00:00:00

  • Diagnosis and management of nail pigmentations.

    abstract::Longitudinal pigmentation of the nail is very common. The differential diagnosis varies from subungual hematoma, to a fungal infection, to a melanocytic lesion (lentigo, nevus melanoma, etc.) to others. Often, dermatologists do not feel at ease with these pathologies and management is often not clear. In many cases, a...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2006.12.021

    authors: Braun RP,Baran R,Le Gal FA,Dalle S,Ronger S,Pandolfi R,Gaide O,French LE,Laugier P,Saurat JH,Marghoob AA,Thomas L

    更新日期:2007-05-01 00:00:00

  • Occurrence of other malignancies in 1973 patients with basal cell carcinoma.

    abstract::To evaluate the possible association of other malignancies with basal cell carcinoma, we reviewed 1973 consecutive patients with basal cell carcinoma. We searched the Swedish Cancer Registry for records reporting malignancies in the study population (1958-1984) and the expected number of malignancies was calculated on...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(91)70189-9

    authors: Lindelöf B,Sigurgeirsson B,Wallberg P,Eklund G

    更新日期:1991-08-01 00:00:00

  • The pathogenesis of psoriasis and the mechanism of action of tazarotene.

    abstract::The 3 major features of psoriasis--abnormal differentiation of keratinocytes, hyperproliferation of keratinocytes, and infiltration of inflammatory components into the skin--can be quantified by measuring levels of certain biochemical markers. Psoriasis is associated with upregulation or downregulation of several of t...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(98)70309-3

    authors: Duvic M,Asano AT,Hager C,Mays S

    更新日期:1998-10-01 00:00:00

  • Granuloma annulare arising in herpes zoster scars. Report of two cases and review of the literature.

    abstract::We present two patients who developed granuloma annulare in the scars from previous herpes zoster. The development of granuloma annulare in herpes zoster scars may represent an atypical delayed hypersensitivity immune reaction to herpes zoster/varicella virus antigen(s) or a tissue antigen altered by the virus. ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(86)70091-1

    authors: Friedman SJ,Fox BJ,Albert HL

    更新日期:1986-05-01 00:00:00

  • Are keloids really "gli-loids"?: High-level expression of gli-1 oncogene in keloids.

    abstract:BACKGROUND:Keloids are a common lesion arising from sites of previous trauma and are a considerable source of morbidity because of continued growth of lesions, pruritus, and physical appearance. They consist of mesenchymal cells embedded in a stroma of disordered collagen matrix. Clinically, keloids are distinguished f...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2001.117736

    authors: Kim A,DiCarlo J,Cohen C,McCall C,Johnson D,McAlpine B,Quinn AG,McLaughlin ER,Arbiser JL

    更新日期:2001-11-01 00:00:00

  • Benign lymphangiomatous papules of the skin.

    abstract::Benign lymphangiomatous papules of the skin are benign lymphatic proliferations that may arise in the skin after operation or radiation therapy. We report a case of benign lymphangiomatous papules of the skin that occurred in a patient 4 years after undergoing radiation therapy to the chest for adenocarcinoma of the b...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2005.01.129

    authors: Wagamon K,Ranchoff RE,Rosenberg AS,Jaworsky C

    更新日期:2005-05-01 00:00:00

  • Current status of surgery in dermatology.

    abstract::An article titled "Current issues in dermatologic office-based surgery" was published in the JAAD in October 1999 (volume 41, issue 4, pp. 624-634). The article was developed by the Joint American Academy of Dermatology/American Society for Dermatologic Surgery Liaison Committee. A number of subjects were addressed in...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2013.04.067

    authors: Hanke CW,Moy RL,Roenigk RK,Roenigk HH Jr,Spencer JM,Tierney EP,Bartus CL,Bernstein RM,Brown MD,Busso M,Carruthers A,Carruthers J,Ibrahimi OA,Kauvar AN,Kent KM,Krueger N,Landau M,Leonard AL,Mandy SH,Rohrer TE,Sadic

    更新日期:2013-12-01 00:00:00

  • Hereditary polymorphic light eruption of American Indians: occurrence in non-Indians with polymorphic light eruption.

    abstract:BACKGROUND:Hereditary polymorphic light eruption (HPLE) occurs unique ly in the American Indian and Inuit and exhibits autosomal dominant transmission. Because the cutaneous expression of HPLE resembles that of polymorphic light eruption (PLE) and because many non-Indians in the United States have American Indian herit...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(96)80060-0

    authors: Fusaro RM,Johnson JA

    更新日期:1996-04-01 00:00:00

  • Annular lichen planus: a case series of 20 patients.

    abstract:BACKGROUND:Annular lichen planus (ALP) is a long-recognized clinical variant of lichen planus, but is often considered uncommon in occurrence. The typical distribution and presentation of this variant have not been well described. OBJECTIVE:We sought to better define the sites affected and clinical characteristics of ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2003.08.011

    authors: Reich HL,Nguyen JT,James WD

    更新日期:2004-04-01 00:00:00

  • JAAD Grand Rounds quiz: A subcutaneous nodule on the right shoulder.

    abstract:LEARNING OBJECTIVES:At the conclusion of this learning activity, physician participants should be able to assess their own diagnostic and patient management skills and use the results of this exercise to help determine personal learning needs. Instructions: In answering each question, refer to the specific directions p...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2013.01.042

    authors: Hung CT,Wang WM

    更新日期:2015-11-01 00:00:00

  • Immunology and photocarcinogenesis. New light on an old problem.

    abstract::Renewed interest in experimental photocarcinogenesis was stimulated by the observation that skin cancers induced in mice by ultraviolet radiation are highly antigenic. Most of these cancers are rejected by the immune system on transplantation into a normal, genetically identical animal. This finding raised the questio...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(86)70017-0

    authors: Kripke ML

    更新日期:1986-01-01 00:00:00

  • Topical 5% imiquimod for the therapy of actinic cheilitis.

    abstract:BACKGROUND:Tissue-destructive and more selective cytotoxic therapies are the main methods used to treat actinic cheilitis. A topical immune stimulant, 5% imiquimod cream, has recently been used for treatment of cutaneous epithelial malignancies including squamous cell carcinoma in situ and basal cell carcinoma. OBJECT...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2002.126266

    authors: Smith KJ,Germain M,Yeager J,Skelton H

    更新日期:2002-10-01 00:00:00

  • Cutaneous zygomycosis in a patient with lymphoma.

    abstract::A large variety of underlying conditions and diseases have been associated with zygomycosis. The most common ones include leukemia or lymphoma, burns, renal failure, septicemia, malnutrition, diabetes, cancer, chemotherapy, organ transplantation, and corticosteroid administration. While being ubiquitous in the environ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(83)80023-1

    authors: Bateman CP,Umland ET,Becker LE

    更新日期:1983-06-01 00:00:00

  • Pyoderma gangrenosum followed by subcorneal pustular dermatosis in a patient with IgA paraproteinemia.

    abstract::Six months after the occurrence of pyoderma gangrenosum, subcorneal pustular dermatosis developed in a 60-year-old woman. The patient's serum was found to contain an IgA-lambda paraprotein. Although similar cases have been reported, this case is unique in that a distinct episode of pyoderma gangrenosum was followed by...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(91)70043-2

    authors: Kohl PK,Hartschuh W,Tilgen W,Frosch PJ

    更新日期:1991-02-01 00:00:00

  • Subcutaneous infiltration of carbon dioxide (carboxytherapy) for abdominal fat reduction: A randomized clinical trial.

    abstract:BACKGROUND:Noninvasive fat removal is preferred because of decreased downtime and lower perceived risk. It is important to seek new noninvasive fat removal treatments that are both safe and efficacious. OBJECTIVE:To assess the extent to which carboxytherapy, which is the insufflation of carbon dioxide gas into subcuta...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaad.2018.04.038

    authors: Alam M,Sadhwani D,Geisler A,Aslam I,Makin IRS,Schlessinger DI,Disphanurat W,Pongprutthipan M,Voravutinon N,Weil A,Chen BR,West DP,Veledar E,Poon E

    更新日期:2018-08-01 00:00:00

  • Controversies in mycosis fungoides.

    abstract::Most clinicians agree that mycosis fungoides is the prototypic cutaneous T cell lymphoma. However, certain clinical characteristics indicate that this disorder may begin as a reactive rather than a neoplastic process. The concept of a nonneoplastic etiopathogenesis of mycosis fungoides is further supported by recent d...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(82)80005-4

    authors: Thiers BH

    更新日期:1982-07-01 00:00:00

  • Patient burden of moderate to severe atopic dermatitis (AD): Insights from a phase 2b clinical trial of dupilumab in adults.

    abstract:BACKGROUND:The adult burden of atopic dermatitis (AD) is poorly characterized. OBJECTIVE:We sought to characterize AD burden in adults with moderate to severe disease from the patient's perspective. METHODS:Patient-reported outcomes collected at screening in a phase 2b clinical trial of dupilumab included pruritus nu...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaad.2015.10.043

    authors: Simpson EL,Bieber T,Eckert L,Wu R,Ardeleanu M,Graham NM,Pirozzi G,Mastey V

    更新日期:2016-03-01 00:00:00

  • Granuloma annulare localized to the palms.

    abstract::Granuloma annulare typically affects the hands and the feet, sparing the volar surfaces. A case of granuloma annulare localized to the palms is described. ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(99)70365-8

    authors: Hsu S,Lehner AC,Chang JR

    更新日期:1999-08-01 00:00:00

  • Epidermal growth factor receptor inhibitors and hair.

    abstract::Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Warren R. Heymann, MD, are provided after each discussion as a topic summary and are provided here as a special service t...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2007.09.007

    authors: Heymann WR

    更新日期:2008-04-01 00:00:00

  • The psychosocial impact of HIV infection--what clinicians can do to help.

    abstract::The psychosocial impact of infection with human immunodeficiency virus (HIV) can be viewed from three perspectives: (1) the issues focused by acquired immunodeficiency syndrome (AIDS), (2) the persons affected, and (3) the emotions encountered. Among the many issues faced by AIDS patients, their families, and their ca...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(90)70177-j

    authors: Cline DJ

    更新日期:1990-06-01 00:00:00

  • Subcutaneous fat in normal and diseased states: 1. Introduction.

    abstract::In recent years, our understanding of adipose tissue physiology and function has undergone an enormous transformation. Once considered a passive storage receptacle with a fixed number of cells and limited purpose, adipose tissue is now recognized as a complicated organ with important endocrine and metabolic functions....

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2005.05.014

    authors: Avram MM,Avram AS,James WD

    更新日期:2005-10-01 00:00:00

  • Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis: Analysis of a cohort of 239 patients.

    abstract:BACKGROUND:Skin pigmentation disorders in systemic sclerosis (SSc) have been sparsely described in the literature. Nevertheless, they could be a diagnostic and/or severity marker. OBJECTIVES:To assess the association between pigmentation disorders and systemic involvement in patients with SSc. METHODS:A total of 5 pa...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2018.07.033

    authors: Leroy V,Henrot P,Barnetche T,Cario M,Darrigade AS,Manicki P,Doutre MS,Lazaro E,Constans J,Barcat D,Vernhes JP,Richez C,Taieb A,Truchetet ME,Seneschal J,Fédération Hospitalo-Universitaire–Aquitaine's Care and Research Organi

    更新日期:2019-02-01 00:00:00

  • Keratosis lichenoides chronica mimicking verrucous secondary syphilis.

    abstract::Keratosis lichenoides chronica is a rare dermatosis of unknown etiology with a wide variety of cutaneous manifestations. We present a 47-year-old male with a history of progressive and recalcitrant hyperkeratotic and warty plaques, mimicking verrucous secondary syphilis both clinically and microscopically. We review t...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/s0190-9622(03)00894-6

    authors: Jayaraman AG,Pomerantz D,Robinson-Bostom L

    更新日期:2003-09-01 00:00:00

  • Yellow nail syndrome: report of five cases.

    abstract::Five patients with the yellow nail syndrome triad are described; all five had yellow nails, primary lymphedema, and respiratory tract involvement. Four of the patients noted the onset of the syndrome after an episode of pneumonia. Four patients had a chronic productive cough, two had bronchiectasis, two had chronic si...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(84)70021-1

    authors: Venencie PY,Dicken CH

    更新日期:1984-02-01 00:00:00

  • Pruritus as a presenting sign of acquired immunodeficiency syndrome.

    abstract::A 65-year-old man with insulin-dependent diabetes developed intractable pruritus preceding weight loss and increasing fatiguability. Esophagogastroduodenoscopy revealed infection with Candida, cytomegalovirus, and Cryptosporidium. His T cell helper/suppressor ratio was inverted, and the serum human immunodeficiency vi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(87)70145-5

    authors: Shapiro RS,Samorodin C,Hood AF

    更新日期:1987-05-01 00:00:00

  • Treatment of mycosis fungoides with photochemotherapy (PUVA): long-term follow-up.

    abstract:BACKGROUND:Mycosis fungoides (MF) is a non-Hodgkin's T-cell lymphoma of the skin that often begins as limited patches and plaques with slow progression to systemic involvement. No studies have been published comparing photochemotherapy (PUVA) with other topical therapies in the treatment of early-stage disease. OBJECT...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(95)90241-4

    authors: Herrmann JJ,Roenigk HH Jr,Hurria A,Kuzel TM,Samuelson E,Rademaker AW,Rosen ST

    更新日期:1995-08-01 00:00:00