当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis: Analysis of a cohort of 239 patients.

Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis: Analysis of a cohort of 239 patients.

Abstract：

BACKGROUND:Skin pigmentation disorders in systemic sclerosis (SSc) have been sparsely described in the literature. Nevertheless, they could be a diagnostic and/or severity marker. OBJECTIVES:To assess the association between pigmentation disorders and systemic involvement in patients with SSc. METHODS:A total of 5 patterns of skin pigmentation disorders were defined: diffuse hyperpigmentation; hyperpigmentation of sun-exposed areas; hypopigmentation of the head, neck, and/or upper part of the chest; acral hypopigmentation; and diffuse hypopigmentation. RESULTS:A total of 239 patients were included; 88 patients (36.8%) had skin pigmentation disorders as follows: diffuse hyperpigmentation and hyperpigmentation of sun-exposed areas in 38.6% (n = 34) and 27.3% (n = 24) of patients, respectively; hypopigmentation of the face, neck, and/or chest in 10.2% of patients (n = 9); diffuse hypopigmentation in 12.5% (n = 11); and acral hypopigmentation in 17% (n = 15). Diffuse hyperpigmentation was associated with diffuse SSc (P = .001), increased modified Rodnan skin score (P = .001), and shorter duration of Raynaud phenomenon (P = .002) in univariate analysis but not in multivariate analysis. Moreover, diffuse hyperpigmentation was associated with digital ulcers (P = .005), as confirmed by multivariate analysis (odds ratio, 2.96; 95% confidence interval, 1.28-6.89). LIMITATIONS:This was a single-center retrospective study of a cohort of patients with SSc. CONCLUSION:Screening for skin pigmentation disorders could be useful in the management of patients with SSc to identify those with a high risk of development of digital ulcers, which is a symptom of vascular involvement in SSc.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Leroy V,Henrot P,Barnetche T,Cario M,Darrigade AS,Manicki P,Doutre MS,Lazaro E,Constans J,Barcat D,Vernhes JP,Richez C,Taieb A,Truchetet ME,Seneschal J,Fédération Hospitalo-Universitaire–Aquitaine's Care and Research Organi

doi

10.1016/j.jaad.2018.07.033

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

478-484

issue

2

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(18)32335-1

journal_volume

80

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY文献大全
  • Epidemiology and treatment of angiolymphoid hyperplasia with eosinophilia (ALHE): A systematic review.

    abstract：BACKGROUND:Current knowledge of angiolymphoid hyperplasia with eosinophilia (ALHE) derives from retrospective reports and case series, leading to a nonevidence-based treatment approach. OBJECTIVE:We sought to systematically review the literature relating to cutaneous ALHE to estimate its epidemiology and treatment out...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2015.10.011

    authors： Adler BL,Krausz AE,Minuti A,Silverberg JI,Lev-Tov H

    更新日期：2016-03-01 00:00:00

  • Long-term results of topical immunotherapy in children with alopecia totalis or alopecia universalis.

    abstract：BACKGROUND:Topical immunotherapy has been used in the treatment of children with alopecia areata with encouraging results. OBJECTIVE:Our purpose was to determine the long-term results in 33 children with severe alopecia areata treated with topical immunotherapy. METHODS:From 1983 to 1989 we treated 33 children with t...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(96)90323-0

    authors： Tosti A,Guidetti MS,Bardazzi F,Misciali C

    更新日期：1996-08-01 00:00:00

  • The risk of rash associated with ipilimumab in patients with cancer: a systematic review of the literature and meta-analysis.

    abstract：BACKGROUND:Ipilimumab is a human antibody that inhibits cytotoxic T-lymphocyte-associated antigen 4, leading to increases in T-cell activation and interleukin 2 secretion and has been approved for the treatment of advanced melanoma. Dermatologic adverse events such as rash, pruritus, and vitiligo have been reported in ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jaad.2012.12.963

    authors： Minkis K,Garden BC,Wu S,Pulitzer MP,Lacouture ME

    更新日期：2013-09-01 00:00:00

  • Eosinophilic spongiosis: a clinical, histologic, and immunopathologic study.

    abstract：BACKGROUND:Epidermal spongiosis with exocytosis of eosinophils (ES) has been reported in biopsy specimens from patients with various dermatoses. Its diagnostic value and the patient's outcome remain poorly understood in those cases in which ES is not associated directly with diagnostic features of a bullous dermatosis....

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(94)70120-2

    authors： Ruiz E,Deng JS,Abell EA

    更新日期：1994-06-01 00:00:00

  • Kinetics of photosensitivity in bath-PUVA photochemotherapy.

    abstract：BACKGROUND:Bath-PUVA is used to treat a variety of dermatoses. However, the kinetics of 8-methoxypsoralen during treatment are not completely clarified. OBJECTIVE:The purpose of this study was to investigate the intensity of the phototoxic response and the persistence of phototoxicity after bath-PUVA. METHODS:Twelve ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(98)70322-6

    authors： Gruss C,Behrens S,Reuther T,Husebo L,Neumann N,Altmeyer P,Lehmann P,Kerscher M

    更新日期：1998-09-01 00:00:00

  • Congenital erythropoietic porphyria: clinical, biochemical, and enzymatic profile of a severely affected infant.

    abstract：:Blistering of light-exposed skin, pink-stained fluorescing diapers, and fluorescing peripheral erythrocytes led to diagnosis of congenital porphyria in an infant born to consanguineous parents. Although massive coproporphyrinuria and coproporphyrinemia initially suggested a coproporphyrinogen oxidase deficiency disord...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(96)90081-x

    authors： Huang JL,Zaider E,Roth P,Garcia O,Pollack S,Poh-Fitzpatrick MB

    更新日期：1996-05-01 00:00:00

  • Current status of surgery in dermatology.

    abstract：:An article titled "Current issues in dermatologic office-based surgery" was published in the JAAD in October 1999 (volume 41, issue 4, pp. 624-634). The article was developed by the Joint American Academy of Dermatology/American Society for Dermatologic Surgery Liaison Committee. A number of subjects were addressed in...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2013.04.067

    authors： Hanke CW,Moy RL,Roenigk RK,Roenigk HH Jr,Spencer JM,Tierney EP,Bartus CL,Bernstein RM,Brown MD,Busso M,Carruthers A,Carruthers J,Ibrahimi OA,Kauvar AN,Kent KM,Krueger N,Landau M,Leonard AL,Mandy SH,Rohrer TE,Sadic

    更新日期：2013-12-01 00:00:00

  • Bullous systemic lupus erythematosus: detection of antibodies against noncollagenous domain of type VII collagen.

    abstract：:A 9-year-old girl with systemic lupus erythematosus developed bullous eruption. Histopathologic examination showed subepidermal blistering and immunoglobulins (IgG, IgM, IgA) and complement components (C1q, C3) deposited linearly at the basement membrane zone. IgG in this patient's serum bound to the dermal side of 1 ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(98)70472-4

    authors： Shirahama S,Furukawa F,Yagi H,Tanaka T,Hashimoto T,Takigawa M

    更新日期：1998-05-01 00:00:00

  • Livedo reticularis: an update.

    abstract：:Livedo reticularis (LR) is a well-known, relatively common physical finding consisting of macular, violaceous, connecting rings that form a netlike pattern (Fig 1). In most cases, it is a completely benign finding related to cold exposure. However, there are many potential causes (Table I), and this can make the evalu...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2004.11.051

    authors： Gibbs MB,English JC 3rd,Zirwas MJ

    更新日期：2005-06-01 00:00:00

  • Primary hyperoxaluria: report of a patient with livedo reticularis and digital infarcts.

    abstract：:Primary hyperoxaluria encompasses 3 rare genetic disorders of glyoxylate metabolism characterized by excessive urinary excretion of oxalic acid, resulting in oxalosis. Patients typically have recurrent calcium oxalate nephrolithiasis and nephrocalcinosis, leading to chronic renal failure and death from uremia. Oxalate...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2002.105475

    authors： Marconi V,Mofid MZ,McCall C,Eckman I,Nousari HC

    更新日期：2002-02-01 00:00:00

  • Granulomatous and suppurative dermatitis at interferon alfa injection sites: report of 2 cases.

    abstract：:It has previously been reported that interferon alfa injection sites may develop pyoderma gangrenosum, interface dermatitis, vasculitis, or, more commonly, ulcers characterized by intravascular thrombi and a mixed inflammatory cell infiltrate. We describe 2 patients in whom granulomatous and suppurative dermatitis dev...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2002.119087

    authors： Sanders S,Busam K,Tahan SR,Johnson RA,Sachs D

    更新日期：2002-04-01 00:00:00

  • A review of phototherapy protocols for psoriasis treatment.

    abstract：:Phototherapy is a mainstay in the treatment of psoriasis and is available as psoralen plus UVA (PUVA), broadband UVB (BB-UVB), and narrowband UVB (NB-UVB). Phototherapy can be administered in the hospital, outpatient clinic, or in the patient's home. The purpose of this review is to provide some practical guidance to ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2009.12.054

    authors： Lapolla W,Yentzer BA,Bagel J,Halvorson CR,Feldman SR

    更新日期：2011-05-01 00:00:00

  • Superantigens in dermatology.

    abstract：:Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against S...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2010.03.044

    authors： Macias ES,Pereira FA,Rietkerk W,Safai B

    更新日期：2011-03-01 00:00:00

  • Langerhans cell histiocytosis and dermatophytosis.

    abstract：:Langerhans cell histiocytosis (LCH) is regarded as a disorder of histiocytic cell proliferation of the Langerhans type, probably resulting from altered immunoregulation. Cutaneous involvement is frequent and often appears as a scaling papular eruption that resembles seborrheic dermatitis; when limited to the scalp, sc...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(93)70191-u

    authors： Pakula AS,Paller AS

    更新日期：1993-08-01 00:00:00

  • Clinically occult cutaneous metastases.

    abstract：:Cutaneous metastases present themselves in a variety of clinical patterns and tend to be manifested as indurated papules/nodules/tumors. Some of those clinical expressions are unique for certain types of metastases. This report describes an entirely different phenomenon of clinically incognito cutaneous metastases tha...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2006.05.011

    authors： Resnik KS,DiLeonardo M,Gibbons G

    更新日期：2006-12-01 00:00:00

  • Sulfur revisited.

    abstract：:Sulfur is a time-honored therapeutic agent useful in a variety of dermatologic disorders. Its keratolytic action is due to formation of hydrogen sulfide through a reaction that depends upon direct interaction between sulfur particles and keratinocytes. The smaller the particle size, the greater the degree of such inte...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(88)70079-1

    authors： Lin AN,Reimer RJ,Carter DM

    更新日期：1988-03-01 00:00:00

  • Use of complementary and alternative medicine among adults with skin disease: updated results from a national survey.

    abstract：BACKGROUND:In the United States, complementary and alternative medicine (CAM) is used for a variety of diseases, including those of the skin. An estimate of the prevalence of CAM use among adults with skin disease using the alternative health supplement of the 2002 National Health Interview Survey (NHIS) has been publi...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2009.12.009

    authors： Fuhrmann T,Smith N,Tausk F

    更新日期：2010-12-01 00:00:00

  • Body dysmorphic disorder symptoms among patients with acne vulgaris.

    abstract：BACKGROUND:Acne is one of the most common concerns of patients with body dysmorphic disorder (BDD), a psychiatric condition defined as a preoccupation with a slight or imagined defect in appearance that causes significant disruption in daily functioning. OBJECTIVE:We sought to screen for BDD symptoms among patients wi...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2007.03.030

    authors： Bowe WP,Leyden JJ,Crerand CE,Sarwer DB,Margolis DJ

    更新日期：2007-08-01 00:00:00

  • Onychomatricoma: genome-wide analyses of a rare nail matrix tumor.

    abstract：BACKGROUND:Onychomatricoma (OM) is a rare benign tumor of the nail matrix in which genome-wide analyses have never been performed. It is clinically characterized by an increased transversal curvature of the nail plate, a longitudinal yellowish discoloration, and splinter hemorrhages. Once the nail plate has been remove...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2009.07.051

    authors： Cañueto J,Santos-Briz Á,García JL,Robledo C,Unamuno P

    更新日期：2011-03-01 00:00:00

  • Penicillamine-induced elastosis of the mucosal lip.

    abstract：:Long-term penicillamine therapy has been associated with alterations in dermal elastic tissue. Well-described associated dermatoses include pseudo-pseudoxanthoma elasticum, acquired cutis laxa, elastosis perforans serpiginosa, and anetoderma. Histologically, "lumpy-bumpy" or "bramble-bush" morphologic changes of elast...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2008.09.018

    authors： Lewis BK,Chern PL,Stone MS

    更新日期：2009-04-01 00:00:00

  • Microphthalmia transcription factor immunohistochemistry: a useful diagnostic marker in the diagnosis and detection of cutaneous melanoma, sentinel lymph node metastases, and extracutaneous melanocytic neoplasms.

    abstract：BACKGROUND:Melanoma is the most lethal form of skin cancer. Diagnosis of amelanotic melanoma and detection of micrometastases in sentinel lymph nodes pose diagnostic and therapeutic dilemmas for the dermatopathologist and clinician. OBJECTIVE:The purpose of this article is to determine the utility of immunohistochemis...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2001.117526

    authors： O'Reilly FM,Brat DJ,McAlpine BE,Grossniklaus HE,Folpe AL,Arbiser JL

    更新日期：2001-09-01 00:00:00

  • New therapies for atopic dermatitis: Additional treatment classes.

    abstract：BACKGROUND:A wide array of miscellaneous agents is being studied for the treatment of atopic dermatitis (AD), including targeted topical, oral systemic, and biologic agents. OBJECTIVE:To review the known efficacy and safety to date for such agents being studied for the treatment of AD. METHODS:A nonsystematic review ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2017.12.024

    authors： Vakharia PP,Silverberg JI

    更新日期：2018-03-01 00:00:00

  • A double-blind, randomized prospective study evaluating topical clobetasol propionate 0.05% versus topical tacrolimus 0.1% in patients with vulvar lichen sclerosus.

    abstract：BACKGROUND:Vulvar lichen sclerosus is a chronic condition usually responsive to topical corticosteroids. OBJECTIVE:We sought to evaluate the efficacy (reduction of signs and symptoms) and safety of clobetasol propionate 0.05% and tacrolimus 0.1% in the treatment of vulvar lichen sclerosus. METHOD:This double-blind, r...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jaad.2014.02.019

    authors： Funaro D,Lovett A,Leroux N,Powell J

    更新日期：2014-07-01 00:00:00

  • Sclerotic fibromas of the skin.

    abstract：:Eleven cases of a peculiar, hyalinized, hypocellular dermal fibroma are reported. The lesions are characterized by epidermal atrophy, a whorled appearance of sclerotic collagen bundles separated by clefts containing mucin, and sharp demarcation of the lesions from the surrounding normal skin. They are small white or f...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(89)70033-5

    authors： Rapini RP,Golitz LE

    更新日期：1989-02-01 00:00:00

  • End points in dermatologic clinical trials: A review for clinicians.

    abstract：:Clinical trials are critical for the development of new therapies in dermatology, and their results help determine US Food and Drug Administration (FDA) approval and guide care. Of special relevance is the clinical trial efficacy end point, the metric from which statistically significant outcome is derived. Clinicians...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2016.01.052

    authors： Wei EX,Kirsner RS,Eaglstein WH

    更新日期：2016-07-01 00:00:00

  • Immunology and photocarcinogenesis. New light on an old problem.

    abstract：:Renewed interest in experimental photocarcinogenesis was stimulated by the observation that skin cancers induced in mice by ultraviolet radiation are highly antigenic. Most of these cancers are rejected by the immune system on transplantation into a normal, genetically identical animal. This finding raised the questio...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0190-9622(86)70017-0

    authors： Kripke ML

    更新日期：1986-01-01 00:00:00

  • Chronic cutaneous damage after accidental exposure to ionizing radiation: the Chernobyl experience.

    abstract：BACKGROUND:The hazards of acute radiation exposure are well known. Bone marrow failure from total body gamma or neutron irradiation is the most clinically relevant aspect of acute radiation disease. With nonhomogeneous exposure, as is characteristic in accidents, other organ systems, such as the skin, may be more impor...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(08)81501-0

    authors： Peter RU,Braun-Falco O,Birioukov A,Hacker N,Kerscher M,Peterseim U,Ruzicka T,Konz B,Plewig G

    更新日期：1994-05-01 00:00:00

  • The significance of crystalline/chrysalis structures in the diagnosis of melanocytic and nonmelanocytic lesions.

    abstract：BACKGROUND:Crystalline/chrysalis structures (CS) are white shiny streaks that can only be seen with polarized dermatoscopy. OBJECTIVES:We sought to estimate the prevalence and assess the clinical significance of CS in melanocytic and nonmelanocytic lesions. METHODS:This was a prospective observational study in which ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2011.04.039

    authors： Balagula Y,Braun RP,Rabinovitz HS,Dusza SW,Scope A,Liebman TN,Mordente I,Siamas K,Marghoob AA

    更新日期：2012-08-01 00:00:00

  • Increased plasma chemoattractant in Sweet's syndrome.

    abstract：:The neutrophil function and plasma leukotactic activity of a patient with Sweet's syndrome and cystonodular acne were evaluated during a 2 1/2-year period. These studies demonstrated that chemotaxis was frequently slightly increased, especially during an exacerbation of Sweet's syndrome, but showed some decrease durin...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(85)70130-2

    authors： Kaplan SS,Wechsler HL,Basford RE,Zdziarski UE,Kuhns DB

    更新日期：1985-06-01 00:00:00

  • Oral dexamethasone pulse treatment for vitiligo.

    abstract：BACKGROUND:Oral corticosteroid pulse therapy has provided inconsistent results in the treatment of Indian patients with vitiligo. OBJECTIVE:We wanted to evaluate the efficacy, safety, and tolerability of oral dexamethasone pulse therapy in a cohort of Austrian patients with vitiligo. METHODS:Twenty-nine patients with...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2001.113475

    authors： Radakovic-Fijan S,Fürnsinn-Friedl AM,Hönigsmann H,Tanew A

    更新日期：2001-05-01 00:00:00