Abstract:
BACKGROUND:Mycosis fungoides (MF) is a non-Hodgkin's T-cell lymphoma of the skin that often begins as limited patches and plaques with slow progression to systemic involvement. No studies have been published comparing photochemotherapy (PUVA) with other topical therapies in the treatment of early-stage disease. OBJECTIVE:The purpose of the study was to examine our long-term experience using PUVA to treat early-stage MF and to compare its effectiveness and side-effect profile with other previously reported topical therapies. METHODS:Eighty-two patients with MF (83% stage IA or IB) were treated with PUVA. Clinical and histologic features were observed for a period from 2 months to 15 years (median, 43 months). RESULTS:A response was noted in 78 patients (95%) with complete clinical and histologic clearing in 53 patients (65%) for all stages. The mean duration of total complete response to PUVA for all stages was 43 months (3.6 years). The mean survival of our study group for all stages was 8.5 years. Signs of chronic actinic skin damage were found in 10% of patients, including three patients with basal cell carcinomas and three patients with squamous cell carcinomas. In a nonrandomized comparison with previously reported data for other topical therapies, the efficacy and side-effect profile of PUVA compared favorably. CONCLUSION:PUVA is an effective and safe therapy for MF with prolonged disease-free remissions being achieved. Patients with stage I and II MF respond best to PUVA. Palliative therapy with PUVA is useful in more advanced cases of MF.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Herrmann JJ,Roenigk HH Jr,Hurria A,Kuzel TM,Samuelson E,Rademaker AW,Rosen STdoi
10.1016/0190-9622(95)90241-4subject
Has Abstractpub_date
1995-08-01 00:00:00pages
234-42issue
2 Pt 1eissn
0190-9622issn
1097-6787pii
0190-9622(95)90241-4journal_volume
33pub_type
杂志文章abstract::A survey was made of the sterile technique practices of dermatologists interested in dermatologic surgery. The steam autoclave is the most popular method for sterilizing surgical instruments. Dry heat sterilization is often used, as is cold, chemical sterilization. The most popular agent for chemical sterilization con...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(88)70114-0
更新日期:1988-05-01 00:00:00
abstract::Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unknown origin that is characterized clinically by annular patches with erythematous borders and hypopigmented centers and histologically by loss of elastic fibers and elastophagocytosis. We report a case of AEGCG in an 8-month-ol...
journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/j.jaad.2005.02.013
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Vulvo-cervico-vaginal involvement has rarely been reported in pemphigus vulgaris (PV) and has not been reported in pemphigus foliaceus (PF). OBJECTIVES:We sought to evaluate genital lesions and Papanicolaou (Pap) smears in female patients with PV and PF. METHODS:This prospective study includes all consecut...
journal_title:Journal of the American Academy of Dermatology
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更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Little is known about how individuals with a predisposition for rosacea appear in childhood. This retrospective, matched control, longitudinal study examined the relationship between childhood stye and adult rosacea. METHODS:The records of the Rochester Epidemiology Project were examined to identify patient...
journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/j.jaad.2006.03.023
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:A new anticancer therapy, electrochemotherapy (ECT), has been introduced that entails exposing cancerous tissues to short pulses of electricity during chemotherapy. This enhances cell membrane permeability and has been shown to have potent antitumor effects in vitro in animal models and in several clinical t...
journal_title:Journal of the American Academy of Dermatology
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abstract::Sunscreen preparations can reduce the erythemogenic ( sunburning ) effects of solar ultraviolet radiation (UVR). Less is known about the ability of sunscreens to protect against other forms of UVR-induced damage. This study was designed to yield data on epidermal cell damage at UVR doses sufficient to provoke vascular...
journal_title:Journal of the American Academy of Dermatology
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更新日期:1984-05-01 00:00:00
abstract::We present a case of cutaneous infection due to Cladophialophora bantiana, an agent of phaeohyphomycosis. The patient developed a nodule with pustule formation on the dorsum of the left hand; no trauma was reported. The lesion was successfully treated with itraconazole and surgical excision. Histopathologically, there...
journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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abstract:BACKGROUND:Established data confirm an increased incidence of skin cancer, mainly squamous cell carcinoma (SCC), in long-term kidney transplant recipients (KTRs). OBJECTIVE:Our purpose was to investigate prospectively the type and frequency of neoplastic and preneoplastic skin lesions in KTRs during the first 3 years ...
journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/0190-9622(95)91276-2
更新日期:1995-10-01 00:00:00
abstract::Melanocytic nevi are commonly believed to undergo changes during pregnancy. This is probably related to hormonal influences; however, few studies have been able to prove it. We observed a case of a benign melanocytic nevus, which showed significant enlargement during pregnancy and immediate postpartum regression assoc...
journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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更新日期:1981-09-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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更新日期:1980-12-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-06-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:1989-08-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:1990-09-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:1981-12-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
abstract::We present the case of an American adult patient with eosinophilic pustular folliculitis. The majority of previously reported patients have been Japanese. Eosinophilic pustular folliculitis is a rare condition characterized by recurrent, peripherally expanding, sterile papulopustules and plaques. Hair-bearing areas su...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:1986-03-01 00:00:00