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High prevalence of transfusion-transmitted virus among patients with non-B, non-C hepatocellular carcinoma.

Abstract：

BACKGROUND:Many patients with hepatocellular carcinoma are positive for hepatitis B surface antigen (HBsAg) or antibodies to hepatitis C virus (anti-HCV). Recently, transfusion-transmitted virus (TTV) DNA was identified in the serum of patients with non-B, non-C posttransfusion hepatitis. In this study, the prevalence of TTV DNA in the serum of patients with non-B, non-C hepatitis-associated hepatocellular carcinoma was evaluated. METHODS:Fifteen patients with hepatocellular carcinoma negative for HBsAg, antibodies to hepatitis B core antigen (anti-HBc), and anti-HCV antibodies were enrolled in this study (non-B, non-C group). Fifteen patients positive for HBsAg and negative for anti-HCV antibody (HBV group) and another group of patients negative for HBsAg but positive for anti-HCV antibody (HCV group) were also enrolled in this study. Data obtained from 27 healthy subjects negative for both HBsAg and anti-HCV antibody and normal levels of serum alanine aminotransferase represented controls. The healthy control group, the non-B, non-C group, and the HCV group were age-matched. TTV DNA was detected by heminested polymerase chain reaction in which specific primers were used. RESULTS:TTV DNA was detected in 10 of 15 patients (67%) in the non-B, non-C group. This prevalence rate in the non-B, non-C group was significantly higher than that in the HBV group (3 of 15 patients, 20%) and the control group (9 of 27 patients, 33%), but it was not significantly different from that in the HCV group (7 of 15 patients, 47%). The noncancerous hepatic tissue samples of 10 TTV-DNA positive patients in the non-B, non-C group included 2 with chronic hepatitis and 8 with cirrhosis. CONCLUSIONS:This study showed that TTV DNA is frequently detected in the serum of patients with non-B, non-C hepatocellular carcinoma. This result suggests a potential pathogenetic association between hepatocellular carcinoma and TTV infection.

journal_name

Cancer

journal_title

Cancer

authors

Nakagawa N,Ikoma J,Ishihara T,Yasui N,Fujita N,Iwasa M,Kaito M,Watanabe S,Adachi Y

subject

Has Abstract

pub_date

1999-10-15 00:00:00

pages

1437-40

issue

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(19991015)86:8<1437::AID-CN

journal_volume

pub_type

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High prevalence of transfusion-transmitted virus among patients with non-B, non-C hepatocellular carcinoma.