Abstract：
:Citric acid has been used as a tussive agent in the investigation of the cough reflex. The mechanism of cough stimulation remains unclear. We conducted studies to compare the cough response of citric acid to an organic (acetic acid) and an inorganic acid (phosphoric acid). We also compared the cough response of citric acid to capsaicin, a non-acid tussive stimulus. In study 1, 26 subjects inhaled equimolar concentrations of citric and acetic acid. In study, 2, 22 subjects inhaled citric acid and phosphoric acid in concentrations of similar pH. Eighteen subjects from study 2 completed a capsaicin cough challenge test. The cough response was recorded and the concentration causing two coughs, the cough threshold, calculated (D2). The correlation of cough thresholds between both citric and acetic acid (r = 0.79, 95% CI 0.37-0.90, P < 0.0001) and citric acid and phosphoric acid (r = 0.68, 95% CI 0.37-0.86, P = 0.0005) were significant. There was no correlation between the citric acid and capsaicin cough thresholds. These results show that an individual's cough response to acetic and phosphoric acid are similar to that caused by citric acid. Thus these acids may cause cough by a common mechanism such as disturbance of the pH of the airway surface liquid. Capsaicin does not appear to share this common pathway.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Wong CH,Matai R,Morice AHdoi
10.1016/s0954-6111(99)90078-1subject
Has Abstractpub_date
1999-01-01 00:00:00pages
58-61issue
1eissn
0954-6111issn
1532-3064pii
S0954-6111(99)90078-1journal_volume
93pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:Holding chambers or spacers can enhance the efficacy of pressurized metered dose inhalers (pMDI) in delivering inhaled medications, as they reduce the need for hand-breath coordination and improve lower airways deposition. Nevertheless, their cost can be high for patients in low-income countries. OBJECTIVE:...
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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更新日期：1995-11-01 00:00:00
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更新日期：2012-01-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-01-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2007-08-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1998-06-01 00:00:00
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pub_type： 杂志文章,评审
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