Abstract:
BACKGROUND:Apoptotic cell death is the major form of myocardial damage produced by coronary ischemic events. OBJECTIVE:To assess whether circulating levels of soluble Fas (sFas), an inhibitor of apoptosis, and sFas ligand, an inducer of apoptosis, in patients with coronary artery disease are greater than normal. METHODS:Forty-seven patients [acute myocardial infarction (AMI) in 17, old myocardial infarction (OMI) in 15, stable angina in 15] and 10 normal control subjects participated in this study. Serum levels of sFas and sFas ligand in all patients were measured, and cardiac catheterizations were performed. RESULTS:Serum levels of sFas were greater than normal only in patients with AMI (4.6 +/- 1.6 ng/ml); the levels were significantly higher than those in patients with OMI (2.1 +/- 0.6 ng/ml) and stable angina (2.2 +/- 0.5 ng/ml), and in normal subjects (2.0 +/- 0.6 ng/ml; P < 0.0001). However, there was no difference among serum levels of sFas ligand for all groups. For patients with AMI, there was no significant correlation between serum levels of sFas and peak levels both of plasma creatine phosphokinase and of plasma myosin light chain type I as clinical indexes of infarct size. However, there were significant correlations between serum levels of sFas and both pulmonary artery wedge pressure (r = 0.767, P = 0.0003) and left ventricular end-diastolic pressure (r = 0.629, P = 0.03). CONCLUSIONS:Circulating sFas increases in concentration in relation to the severity of hemodynamic conditions in patients with AMI, but it is independent from size of infarct. Therefore, circulating sFas could play an important role as the marker of pathophysiologic conditions associated with cardiomyocyte apoptosis in AMI.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Ohtsuka T,Hamada M,Sasaki O,Suzuki M,Hara Y,Shigematsu Y,Ohtani T,Honda T,Hiwada Kdoi
10.1097/00019501-199906000-00003subject
Has Abstractpub_date
1999-06-01 00:00:00pages
221-5issue
4eissn
0954-6928issn
1473-5830journal_volume
10pub_type
杂志文章abstract:BACKGROUND:We investigated whether diffuse coronary vasoconstriction induced by acetylcholine caused myocardial ischemia. METHODS:We studied 30 patients (40 coronary arteries) with spontaneous chest pain or equivocal studies on treadmill exercise testing and no significant coronary stenosis or previous myocardial infa...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Coronary artery bypass grafting has been performed for a long period utilizing saphenous vein grafts, the fate of which might be crucial to prognosis following the operation. Metabolic syndrome, on the other hand, has become an increasingly important part of cardiovascular practice. We examined whether there...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200602000-00007
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the association of plasma osmolality with all-cause mortality in ST-segment elevation myocardial infarction (STEMI) patients treated with a primary percutaneous coronary intervention. METHODS:This study included 3748 patients (mean age 58.3±11.8 years, men 81%) with ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000426
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Drug-coated balloon (DCB) angioplasty has emerged as an effective management strategy worldwide. In June 2016, DCB became available for the treatment of de novo small coronary lesions in Japan; however, there has been no multicenter analysis in a post-approval real-world clinical setting to date. The aim of t...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000782
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the efficacy and safety of intracoronary administration of prourokinase via balloon catheter during primary percutaneous coronary interventions in patients with acute ST-segment elevation myocardial infarction. METHODS:Acute ST-segment elevation myocardial infarction patients underwent primary p...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000898
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:To evaluate immediate changes in left ventricular wall motion in patients treated using Biosense direct myocardial revascularization laser system. METHODS:Regional wall motion in 10 patients undergoing catheter-based direct myocardial revascularization using a holmium:yttrium aluminium garnet laser was asses...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200006000-00010
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Serum gamma-glutamyl transferase (GGT) activity, an enzyme responsible for the extracellular catabolism of antioxidant glutathione, may directly take part in atherogenesis and evolve as a potential biochemical risk indicator of cardiovascular morbidity and mortality. An important characteristic of coronary a...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32830eaba1
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Percutaneous coronary intervention-induced myocardial infarction (PMI) has prognostic significance. Identifying patients at high risk for PMI is desirable as it may alter strategy and facilitate early preventative therapy. We therefore sought to establish whether preprocedural demographic, interventional (pl...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000582
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Red cell distribution width (RDW), a measure of red blood cell size heterogeneity, was evaluated in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Higher RDW is associated with mortality in patients with symptomatic car...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328342c77b
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Heart rate variability (HRV) time and frequency domain indices are strong predictors of malignant arrhythmias and sudden cardiac death. The effect of various angiotensin-converting enzyme (ACE) inhibitors on HRV in patients with acute myocardial infarction (AMI) has not been studied. METHODS:Ninety patients...
journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Anemia is associated with an increased risk of mortality in patients who underwent percutaneous coronary intervention (PCI) in the bare-metal stent era. However, there have been no data concerning the clinical importance of anemia improvement during the follow-up period after discharge from the hospital duri...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3283564869
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Calcified coronary lesions have commonly been considered as a challenge for interventional cardiologists, and few previous studies of sirolimus-eluting stent (SES) for calcified lesion have been limited by small sample size. Therefore, we evaluated the effectiveness of SES implantation for the treatment of c...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328330d5ab
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:We have recently demonstrated that low-energy extracorporeal shock wave therapy improves chronic myocardial ischemia in pigs and humans. In this study, we examined whether our shock wave therapy is also effective at improving left ventricular remodeling after acute myocardial infarction in pigs. METHODS:Acut...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328089f19b
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:The relationship between the serum levels of atherosclerosis-related apolipoprotein (apo) and the risk of coronary spastic angina remains unknown. METHODS AND RESULTS:This study consists of 111 patients who were admitted to our facility with the chief complaint of chest pain, in whom coronary angiography sh...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328341baa9
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Bifurcation lesions represent a distinct lesion subset associated with an increased risk of procedural complications. Data on the incidence, treatment, and outcome of bifurcation lesions associated with chronic total occlusions are limited. METHODS:Among chronic total occlusion procedures performed by a sin...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000194
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To determine whether a quantitative measurement of peak systolic velocity (PSV) during dobutamine stress echocardiography (DSE) detects severe coronary artery disease (CAD) and predicts mortality in patients with end-stage renal disease. METHODS:One hundred and forty renal transplant candidates had DSE and c...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32832ac5eb
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Elderly patients with ischaemic heart disease are often treated more conservatively and for longer than younger patients, but this strategy may result in subsequent invasive intervention of more advanced and higher risk coronary disease. METHODS:We performed a retrospective analysis of 109 patients aged > o...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199711000-00006
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVES:The activity of matrix Gla-protein (MGP), a potent inhibitor of vascular calcification, is dependent on carboxylation using vitamin K as a co-factor. In animals, low intake of total vitamin K has been shown to accelerate vascular calcification via the MGP mechanism. This has led to the hypothesis that low le...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200505000-00010
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Thrombomodulin (TM) -33G/A and Ala455Val polymorphisms have been indicated to be correlated with the risk of coronary artery disease (CAD), but study results are still inclusive. Thus, a meta-analysis was carried out. MATERIALS AND METHODS:Databases including PubMed, Embase, CNKI, and Web of Science (ISI) w...
journal_title:Coronary artery disease
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MCA.0000000000000161
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:17 beta-Estradiol and phytoestrogens are known to have beneficial effects on the cardiovascular systems of women. The exact mechanisms for how estrogens and phytoestrogens influence the cardiovascular system are not yet understood in detail. OBJECTIVE:The objective of this study was to investigate whether 1...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199912000-00010
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:There are few reports regarding the concordance of coronary arterial response between acetylcholine (ACh) and ergonovine (ER) spasm provocation tests. OBJECTIVES:We attempted to perform selective spasm provocation tests to examine the incidence of provoked spasm in patients who had undergone first coronary ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200412000-00006
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:The effects of initial tests on long-term events have been unknown. PATIENTS AND METHODS:In this observational retrospective study, we analyzed the effects of initial noninvasive tests by myocardial perfusion imaging (MPI) and computed tomography angiography (CTA) on long-term major adverse cardiac events (...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0000000000000645
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Measurement of antibodies to oxidized low-density lipoprotein (AB-oxLDL) has been proposed as a way of identifying individuals at risk for cardiovascular disease beyond the determination of LDL cholesterol (LDL-c) alone. While this hypothesis is appealing, evidence that AB-oxLDL is a risk factor independent ...
journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00019501-200304000-00009
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:T-cell-mediated immune responses play important roles in the progression of atherosclerotic disease. Studies have linked various inflammatory biomarkers with the burden of coronary artery calcification, but the significance of T-cell-specific chemokines in coronary artery calcification has not been confirmed...
journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章
doi:10.1097/MCA.0000000000000236
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Platelet-activating factor is a biologically potent phospholipid that may mediate cell damage in patients with myocardial ischemia. In plasma, its inactivation to lyso-platelet-activating factor is catalyzed by a specific, lipoprotein-associated acetylhydrolase. Because lipoprotein levels decrease after myoc...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199302000-00009
更新日期:1993-02-01 00:00:00
abstract::Radiofrequency ablation of complex cardiac arrhythmias has undergone significant evolution in the past decade, with the development of technology enabling better anatomic and electrophysiologic mapping of abnormal cardiac tissue. In this paper, we will discuss the role of pre-procedural and post-procedural multidetect...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/00019501-200603000-00005
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to clarify clinical and angiographical characteristics of acetylcholine (ACh)-induced spasm in the right and left coronary artery. METHODS AND RESULTS:We performed 557 consecutive procedures of spasm provocation tests of ACh from January 1991 to December 2000 in patients withou...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200206000-00005
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Both experimental and pathological studies suggest that immune response and inflammation may play an important role in the pathogenesis of coronary spasm. DESIGN:To elucidate the role of systemic immune and inflammatory responses in the pathogenesis of coronary spasm, we studied circulating T-lymphocyte act...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200205000-00005
更新日期:2002-05-01 00:00:00
abstract:AIM:We evaluated the accuracy of multidetector computed tomography in detecting coronary artery disease and how it could change the indication to coronary angiography in patients with suspected cardiac chest pain. METHODS AND RESULTS:We enrolled 142 consecutive patients who had already performed an exercise electrocar...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328035f8ae
更新日期:2007-06-01 00:00:00
abstract::Cardiac hypertrophy is a physiological adaptive response by the heart to pressure overload. However, after prolonged periods, this initial adaptive response becomes maladaptive, leading to increased mortality and morbidity from heart failure. Recently, 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibit...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/01.mca.0000130229.18685.b9
更新日期:2004-08-01 00:00:00