Abstract:
OBJECTIVES:The activity of matrix Gla-protein (MGP), a potent inhibitor of vascular calcification, is dependent on carboxylation using vitamin K as a co-factor. In animals, low intake of total vitamin K has been shown to accelerate vascular calcification via the MGP mechanism. This has led to the hypothesis that low levels of dietary vitamin K intake may be a risk factor for accelerated vascular calcification in humans due to decreased MGP activity. Additionally, some authors have suggested that current recommended daily intake values for vitamin K might be insufficient to fully inhibit vascular calcification via the MGP mechanism. The aim of this study was to examine the relationship between dietary vitamin K1 (the most prevalent dietary form of vitamin K) intake and premature coronary artery calcification (CAC) in an asymptomatic screening population. METHODS:We conducted a prospective study of 807 consecutive active-duty US Army personnel, 39-45 years of age, without known coronary heart disease. Vitamin K1 intake was measured with the Block Dietary Questionnaire and CAC was identified using electron-beam computed tomography (EBCT). RESULTS:We found no significant correlation between CAC score and vitamin K1 intake (r = 0.132, P = 0.106). Multivariate analysis with adjustment for cardiac risk factors showed no association between dietary vitamin K1 intake and CAC. CONCLUSIONS:Dietary vitamin K1 (phylloquinone) intake appears to be unrelated to premature coronary calcification in a screening population. Further investigation into the relationship of vascular calcification and other forms of vitamin K1 (menaquinones) is indicated.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Villines TC,Hatzigeorgiou C,Feuerstein IM,O'Malley PG,Taylor AJdoi
10.1097/00019501-200505000-00010subject
Has Abstractpub_date
2005-05-01 00:00:00pages
199-203issue
3eissn
0954-6928issn
1473-5830pii
00019501-200505000-00010journal_volume
16pub_type
杂志文章abstract:BACKGROUND:Both systolic and diastolic dysfunction have been observed in patients with anterolateral myocardial infarction. Diastolic dysfunction is related to disturbances in relaxation and diastolic filling. OBJECTIVE:To analyse cardiac rotation, regional shortening and diastolic relaxation in patients with anterola...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200005000-00009
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:In response to the growing use of imaging-based cardiac stress tests in the evaluation of stable ischemic heart disease, professional societies have developed appropriate use criteria (AUC). AUC will soon be linked to reimbursement of advanced diagnostic imaging for Medicare beneficiaries via Clinical Decisio...
journal_title:Coronary artery disease
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abstract:OBJECTIVES:Limited data exist about the prognostic significance of new-onset atrial fibrillation (AF) after contemporary primary percutaneous coronary intervention (pPCI). The objective of this study was to identify the incidence and predictors of new-onset AF and associated adverse 30-day outcomes in AF patients who u...
journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章
doi:10.1097/MCA.0b013e32834df552
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:17 beta-Estradiol and phytoestrogens are known to have beneficial effects on the cardiovascular systems of women. The exact mechanisms for how estrogens and phytoestrogens influence the cardiovascular system are not yet understood in detail. OBJECTIVE:The objective of this study was to investigate whether 1...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199912000-00010
更新日期:1999-12-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000189
更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1097/00019501-200609000-00001
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to clarify clinical and angiographical characteristics of acetylcholine (ACh)-induced spasm in the right and left coronary artery. METHODS AND RESULTS:We performed 557 consecutive procedures of spasm provocation tests of ACh from January 1991 to December 2000 in patients withou...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200206000-00005
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/MCA.0b013e3283093707
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journal_title:Coronary artery disease
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doi:10.1097/00019501-200009000-00002
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000582
更新日期:2018-05-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/01.mca.0000064020.05024.e5
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200010000-00003
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000791
更新日期:2020-03-01 00:00:00
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journal_title:Coronary artery disease
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doi:10.1097/MCA.0b013e328334eb46
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200302000-00010
更新日期:2003-02-01 00:00:00
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journal_title:Coronary artery disease
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doi:10.1097/MCA.0000000000000094
更新日期:2014-08-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
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journal_title:Coronary artery disease
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32833fd29b
更新日期:2010-12-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
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journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
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更新日期:2019-05-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200411000-00008
更新日期:2004-11-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199307000-00010
更新日期:1993-07-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3283587897
更新日期:2012-11-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章,评审
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更新日期:2005-03-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199612000-00002
更新日期:1996-12-01 00:00:00
abstract::The Editor and Associate Editors are pleased that our readership will have the opportunity to benefit from a series of contributions by Dr John Rutherford addressing current issues in pharmacology and therapeutics pertinent to coronary artery disease. We are pleased also that Dr Rutherford will provide authoritative p...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200012000-00008
更新日期:2000-12-01 00:00:00