Comparison of peripheral arterial tonometry and flow-mediated vasodilation for assessment of the severity and complexity of coronary artery disease.


OBJECTIVE:Noninvasive flow-mediated vasodilation (FMD) is a widely used method to assess endothelial function, but its technical difficulty and problems remain obstacles for use in clinical practice. Reactive hyperemia-peripheral arterial tonometry (RH-PAT) was developed as a simpler and more reproducible method. We compared FMD and RH-PAT in patients with stable angina. Furthermore, the differences in these two techniques according to coronary artery disease (CAD) severity and complexity were also assessed. MATERIALS AND METHODS:We consecutively enrolled 80 patients who underwent elective coronary angiography. Endothelial function was assessed before angiography using brachial artery FMD and RH-PAT. The complexity and extent of the coronary lesions were assessed angiographically. The extent of CAD was defined as the number of diseased coronary arteries (>70%) and complexity of CAD was assessed by the SYNTAX score algorithm. RESULTS:In the overall study group (61±9 years, 57% men), the mean FMD was 8.5±5.1% and the mean reactive hyperemia index (RHI) measured by RH-PAT was 1.7±0.4. A significant correlation was observed between FMD and RHI irrespective of sex, diabetes, or presence of CAD. FMD and RHI were significantly lower in patients with multivessel and complex CAD. A receiver-operating characteristic curve analysis showed that both techniques were comparable in terms of predicting the presence of CAD and complexity. CONCLUSION:Assessment of RH-PAT could be a less operator-dependent and noninvasive method of evaluating vascular endothelial function in patients with stable angina.


Coron Artery Dis


Coronary artery disease


Woo JS,Jang WS,Kim HS,Lee JH,Choi EY,Kim JB,Kim WS,Kim KS,Kim W




Has Abstract


2014-08-01 00:00:00












  • Acute right ventricular infarction: clinical spectrum, results of reperfusion therapy and short-term prognosis.

    abstract:BACKGROUND:The role of thrombolytic therapy (TT) and percutaneous coronary interventions (PCIs) in subgroups of patients with right ventricular infarction (RVI) has not been evaluated. METHODS AND RESULTS:We risk-stratified 302 patients with RVI into three subsets upon admission. Class A (n=197) comprised patients wit...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Lupi-Herrera E,Lasses LA,Cosio-Aranda J,Chuquiure-Valenzuela E,Martínez-Sánchez C,Ortiz P,González-Pacheco H,Juárez-Herrera U,Rodriguez Mdel C,Vargas-Barrón J,Martínez-Rios MA

    更新日期:2002-02-01 00:00:00

  • Suboptimal coronary blood flow after primary percutaneous coronary intervention for acute myocardial infarction: incidence, a simple risk score, and prognosis.

    abstract:BACKGROUND:The aim of the present study is to investigate incidence, predictors, and long-term outcomes of suboptimal coronary flow after primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) in a large population. METHODS:A total of 2056 consecutive patients with STEMI (mean ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Uyarel H,Ayhan E,Cicek G,Isik T,Ugur M,Bozbay M,Yildirim E,Ergelen M,Eren M

    更新日期:2012-03-01 00:00:00

  • Comparison of 2-year outcomes of repeated second-generation drug-eluting stent implantation for focal-type versus nonfocal-type in-stent restenosis.

    abstract:BACKGROUND:Second-generation drug-eluting stents (DES) have been used widely to treat DES in-stent restenosis (ISR), which remains a clinical challenge. Knowledge of the outcomes of repeated second-generation DES implantation for focal versus nonfocal-type ISR is still missing. METHODS:In the current study, 254 patien...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Zhu W,Li J,Luo H,Wang G,Hua Q

    更新日期:2015-11-01 00:00:00

  • Appropriate use of multimodality stress testing for chest pain in new patient referrals to cardiologists.

    abstract:OBJECTIVE:In response to the growing use of imaging-based cardiac stress tests in the evaluation of stable ischemic heart disease, professional societies have developed appropriate use criteria (AUC). AUC will soon be linked to reimbursement of advanced diagnostic imaging for Medicare beneficiaries via Clinical Decisio...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Lam DH,Tiwana J,Li S,Kirkpatrick JN,Cheng RK

    更新日期:2020-08-13 00:00:00

  • Transradial approach in patients with ST-elevation myocardial infarction treated with abciximab results in fewer bleeding complications: data from EUROTRANSFER registry.

    abstract:OBJECTIVES:Our aim was to investigate the safety and efficacy of transradial approach, predictors of bleeding complications, and choice of radial access site in a real-life setting using a contemporary European registry of percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI). BACKGROU...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Siudak Z,Zawislak B,Dziewierz A,Rakowski T,Jakala J,Bartus S,Noworolnik B,Zasada W,Dubiel JS,Dudek D

    更新日期:2010-08-01 00:00:00

  • Clinical outcomes of SeQuent Please paclitaxel-coated balloons for de novo small coronary artery lesion in a Japanese multicenter post-approval registry.

    abstract:OBJECTIVE:Drug-coated balloon (DCB) angioplasty has emerged as an effective management strategy worldwide. In June 2016, DCB became available for the treatment of de novo small coronary lesions in Japan; however, there has been no multicenter analysis in a post-approval real-world clinical setting to date. The aim of t...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Funayama N,Muratsubaki S,Kawahatsu K,Miyata M,Katou Y,Oikawa T

    更新日期:2020-01-01 00:00:00

  • Beneficial effect of HEPES buffer in repeated coronary reperfusion.

    abstract:BACKGROUND:We have demonstrated previously that, when repeated reperfusion is performed after reocclusion, there is a decrease in the amount of myocardial salvage, despite early reperfusion. Treatment with nisoldipine induced a beneficial effect by reduction of infarct size in this experimental model. OBJECTIVE:To stu...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Hammerman H,Ramadan R,Hir J,Moscovitz M

    更新日期:2000-03-01 00:00:00

  • Association of coronary artery calcium with bone mineral density in postmenopausal women.

    abstract:OBJECTIVES:Atherosclerosis and osteoporosis (OP) are common diseases in elderly individuals and may share common pathogenetic mechanisms. The aim of this study was to investigate the association between bone mineral density (BMD) and coronary artery calcium (CAC) in postmenopausal women. METHODS:In this cross-sectiona...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Xu R,Yang HN,Li YQ,Wang QF,Guo AH,Ayiti A,Chen XC,Gong R,Banu G,Jian LD,Gao Y,Sheng K,Maimti Y

    更新日期:2016-11-01 00:00:00

  • Metabolic syndrome negatively impacts early patency of saphenous vein grafts.

    abstract:BACKGROUND:Coronary artery bypass grafting has been performed for a long period utilizing saphenous vein grafts, the fate of which might be crucial to prognosis following the operation. Metabolic syndrome, on the other hand, has become an increasingly important part of cardiovascular practice. We examined whether there...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yilmaz MB,Guray U,Guray Y,Biyikoglu SF,Tandogan I,Sasmaz H,Korkmaz S

    更新日期:2006-02-01 00:00:00

  • Comparative effectiveness of different contemporary drug-eluting stents in routine clinical practice: a multigroup propensity score analysis using data from the stent-specific, multicenter, prospective registries.

    abstract:OBJECTIVE:Data on the comparative effectiveness of contemporary drug-eluting stents (DES) in the unrestricted, real-world setting are limited. We investigated the long-term effectiveness and safety of contemporary different drug-eluting stents by means of multiple treatment propensity score weighting. PATIENTS AND MET...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Kwon O,Kang SH,Lee JB,Ahn JM,Lee CH,Kang DY,Lee PH,Kang SJ,Lee SW,Kim YH,Lee CW,Park SW,Park DW,Park SJ,IRIS-DES Registry Investigators.

    更新日期:2019-06-01 00:00:00

  • Attenuation of cardiac vascular rhexis: a promising therapeutic target.

    abstract:BACKGROUND:We have previously identified a phenomenon that we called vascular rhexis (VR) after coronary occlusion in mice. To explore its potential pathogenetic impact on the destruction of vessels described, its potential universality, and its characterization as a scaffolding for evaluating amelioration, we studied ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Tarikuz Zaman AK,Spees JL,Sobel BE

    更新日期:2013-05-01 00:00:00

  • Tako-tsubo cardiomyopathy and coronary artery disease: a possible association.

    abstract:BACKGROUND:In the medical literature, several cases of Tako-tsubo cardiomyopathy (TTC) with coronary artery disease (CAD) have been reported, and in clinical practice, several typical TTC cases show relevant stenoses of the coronary arteries spatially unrelated to the dysfunctional myocardium. OBJECTIVE:This study aim...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Parodi G,Citro R,Bellandi B,Del Pace S,Rigo F,Marrani M,Provenza G,Leoncini M,Salerno Uriarte JA,Bovenzi F,Bossone E,Tako-tsubo Italian Network (TIN).

    更新日期:2013-09-01 00:00:00

  • Effects of lipid-lowering therapy on coronary artery remodeling.

    abstract:BACKGROUND:Although lipid-lowering therapy affects the luminal size of atherosclerotic coronary arteries the role of vascular remodeling has not been systematically studied. DESIGN/METHODS:Serial three-dimensional volumetric intravascular ultrasound (IVUS) was used to study remodeling, which was defined as changes in ...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Schartl M,Bocksch W,Fateh-Moghadam S

    更新日期:2004-02-01 00:00:00

  • Fetuin-A is associated with calcified coronary artery disease.

    abstract:OBJECTIVE:Fetuin-A is a circulating glycoprotein that is involved in various stages of atherosclerosis. Despite the fact that emerging evidence suggests fetuin-A acts as a calcification inhibitor that protects against advanced calcified atherosclerosis in dialyzed patients, the role of fetuin-A in cardiovascular diseas...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Mori K,Ikari Y,Jono S,Emoto M,Shioi A,Koyama H,Shoji T,Ishimura E,Inaba M,Hara K,Nishizawa Y

    更新日期:2010-08-01 00:00:00

  • A brief review of the past and future of platelet P2Y12 antagonist.

    abstract::ADP plays a pivotal role in localized platelet activation and recruitment, and, with that, in the maintenance of thrombus integrity, making it a suitable target for the control of intravascular thrombosis. The limited distribution of one of its receptors, the P2Y12 receptor, primarily to platelets makes it an especial...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Barn K,Steinhubl SR

    更新日期:2012-09-01 00:00:00

  • Hospitalisations, infarct development, and mortality in patients with chest pain and a normal admission electrocardiogram in relation to gender.

    abstract:BACKGROUND:The aim of this study was to compare the outcome for men and women with chest pain or other symptoms suggestive of acute myocardial infarction (AMI) and a normal ECG on admission. METHODS:All patients who presented to our emergency room over a 21-month period with chest pain or other symptoms suggestive of ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Karlson BW,Herlitz J

    更新日期:1996-03-01 00:00:00

  • Myocardial revascularisation in elderly patients with refractory or unstable angina and advanced coronary disease.

    abstract:BACKGROUND:Elderly patients with ischaemic heart disease are often treated more conservatively and for longer than younger patients, but this strategy may result in subsequent invasive intervention of more advanced and higher risk coronary disease. METHODS:We performed a retrospective analysis of 109 patients aged > o...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Vassilikos VP,Lim R,Kreidieh I,Nathan AW,Edmondson SJ,Rees GM,Banim SO,Dymond DS

    更新日期:1997-11-01 00:00:00

  • Association of the serum apolipoprotein levels with the occurrence of coronary vasospasm.

    abstract:BACKGROUND:The relationship between the serum levels of atherosclerosis-related apolipoprotein (apo) and the risk of coronary spastic angina remains unknown. METHODS AND RESULTS:This study consists of 111 patients who were admitted to our facility with the chief complaint of chest pain, in whom coronary angiography sh...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Tani S,Nagao K,Kawamorita T,Hirayama A

    更新日期:2011-05-01 00:00:00

  • Sequelae of spinal cord stimulation for refractory angina pectoris. Reliability and safety profile of long-term clinical application.

    abstract:BACKGROUND:Spinal cord stimulation (SCS) is effective in the treatment of severe coronary artery disease (CAD) unresponsive to anti-anginal medication or revascularization procedures. However, there is still concern about its safety. OBJECTIVE:To investigate the reliability, morbidity, and mortality aspects of SCS in ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Jessurun GA,Ten Vaarwerk IA,DeJongste MJ,Tio RA,Staal MJ

    更新日期:1997-01-01 00:00:00

  • Hemodynamic changes determine the efficacy of thrombolysis: results from an in-vitro flow model.

    abstract:BACKGROUND:The efficacy of thrombolytic therapy might be influenced by changes in the hemodynamic status. The aim of the study was to examine whether changes in perfusion pressure could affect the time to reflow in an in-vitro model. METHODS:The in-vitro flow system comprised flexible plastic tubes that enclosed a blo...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Kornowski R,Mendelevich L,Zaretsky U,Einav S,Laniado S,Keren G

    更新日期:1998-01-01 00:00:00

  • Relation between N-terminal pro-B-type natriuretic peptide and coronary plaque components in patients with acute coronary syndrome: virtual histology-intravascular ultrasound analysis.

    abstract:BACKGROUND:The N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is a sensitive indicator of hemodynamic stress and its increased level is associated with higher mortality in acute coronary syndrome (ACS) patients. Virtual histology-intravascular ultrasound (VH-IVUS) can provide quantitative information on plaque ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Hong YJ,Ahn Y,Sim DS,Yoon NS,Yoon HJ,Kim KH,Park HW,Kim JH,Jeong MH,Cho JG,Park JC,Kang JC

    更新日期:2009-12-01 00:00:00

  • Risk factors and comorbidities in a community-wide sample of patients hospitalized with acute systolic or diastolic heart failure: the Worcester Heart Failure Study.

    abstract:OBJECTIVES:Few epidemiological studies have examined differences in the prevalence of risk factors and comorbidities in patients with systolic heart failure (HF), as compared with those with diastolic HF. METHODS:We analyzed data from 1426 residents of the Worcester (MA) metropolitan area hospitalized at all 11 greate...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Chinali M,Joffe SW,Aurigemma GP,Makam R,Meyer TE,Goldberg RJ

    更新日期:2010-05-01 00:00:00

  • Rosuvastatin improves the atherogenic and atheroprotective lipid profiles in patients with hypertriglyceridemia.

    abstract:BACKGROUND:We examined the effects of rosuvastatin treatment on triglyceride levels and lipid measures in a parallel-group multicenter trial (4522IL/0035) in patients with hypertriglyceridemia (Fredrickson Type IIb or IV). METHODS:After a 6-week dietary lead-in period while on a National Cholesterol Education Program ...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Hunninghake DB,Stein EA,Bays HE,Rader DJ,Chitra RR,Simonson SG,Schneck DW

    更新日期:2004-03-01 00:00:00

  • Myocardial Doppler tissue velocity improves following myocardial gene therapy with VEGF-A165 plasmid in patients with inoperable angina pectoris.

    abstract:BACKGROUND:Myocardial tissue velocity and perfusion were studied in patients with severe angina pectoris following gene therapy by intramyocardial injection of phVEGF-A165 via thoracotomy. Plasma concentrations of VEGF-A increased postoperatively. Two months after treatment anginal status and myocardial tissue velocity...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Sylvén C,Sarkar N,Rück A,Drvota V,Hassan SY,Lind B,Nygren A,Källner Q,Blomberg P,van der Linden J,Lindblom D,Brodin LA,Islam KB

    更新日期:2001-05-01 00:00:00

  • Incidence, treatment, and in-hospital outcome of bifurcation lesions in patients undergoing percutaneous coronary interventions for chronic total occlusions.

    abstract:BACKGROUND:Bifurcation lesions represent a distinct lesion subset associated with an increased risk of procedural complications. Data on the incidence, treatment, and outcome of bifurcation lesions associated with chronic total occlusions are limited. METHODS:Among chronic total occlusion procedures performed by a sin...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Galassi AR,Boukhris M,Tomasello SD,Marzà F,Azzarelli S,Giubilato S,Khamis H

    更新日期:2015-03-01 00:00:00

  • Early versus delayed coronary artery bypass graft surgery for patients with non-ST elevation myocardial infarction.

    abstract:BACKGROUND:Although coronary artery bypass graft surgery (CABG) has been proven to have mortality and morbidity benefits in patients with non-ST elevation myocardial infarction and multivessel disease, the appropriate timing of this procedure remains unclear. Therefore, we proposed a propensity score-matched analysis c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ha LD,Ogunbayo G,Elbadawi A,Olorunfemi O,Messerli A

    更新日期:2017-12-01 00:00:00

  • Frequency-domain optical coherence tomography plaque morphology in stable coronary artery disease: sex differences.

    abstract:BACKGROUND:The cause for discrepancy in the clinical presentation and outcome of coronary artery disease (CAD) between men and women is not established. Different prevalences of risk factors or specific sex-related atherosclerotic aspects have been advocated as possible explanations. We investigated coronary plaque mor...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Mariani L,Burzotta F,Aurigemma C,Romano A,Niccoli G,Leone AM,Porto I,Trani C,Crea F

    更新日期:2017-09-01 00:00:00

  • Expression of monocyte and lymphocyte adhesion molecules is increased in isolated coronary artery ectasia.

    abstract:BACKGROUND:Coronary artery ectasia is defined as localized or diffuse dilation of the coronary arteries exceeding the 1.5-fold of normal adjacent segment. Scarce data are available about the role of inflammation in coronary artery ectasia. In the present study, we aimed to evaluate the expression of CD11b and CD45 adhe...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yildirim N,Tekin IO,Dogan SM,Aydin M,Gursurer M,Cam F,Gungorduk A,Akoz A

    更新日期:2007-02-01 00:00:00

  • Can we use plasma hyperosmolality as a predictor of mortality for ST-segment elevation myocardial infarction?

    abstract:BACKGROUND:The aim of this study was to investigate the association of plasma osmolality with all-cause mortality in ST-segment elevation myocardial infarction (STEMI) patients treated with a primary percutaneous coronary intervention. METHODS:This study included 3748 patients (mean age 58.3±11.8 years, men 81%) with ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Tatlisu MA,Kaya A,Keskin M,Uzman O,Borklu EB,Cinier G,Hayiroglu MI,Tatlisu K,Eren M

    更新日期:2017-01-01 00:00:00

  • New carotid plaque, but not the progression of intima-media thickness, predicts the progression of high-risk coronary plaque.

    abstract:BACKGROUND:Carotid intima-media thickness (CIMT) is regarded as a controversial risk marker for cardiovascular disease (CVD). We aimed to evaluate the role of CIMT and carotid plaque progression as predictors for the progression of coronary plaque and compositions. METHODS:In the Garlic 4 study, asymptomatic patients ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Chao CJ,Lakshmanan S,Ceponiene I,Luo Y,Nakanishi R,Nezarat N,Kanisawa M,Budoff MJ

    更新日期:2021-01-06 00:00:00