The diagnostic and prognostic value of tissue Doppler imaging during dobutamine stress echocardiography in end-stage renal disease.


OBJECTIVE:To determine whether a quantitative measurement of peak systolic velocity (PSV) during dobutamine stress echocardiography (DSE) detects severe coronary artery disease (CAD) and predicts mortality in patients with end-stage renal disease. METHODS:One hundred and forty renal transplant candidates had DSE and coronary angiography. DSE analysis was performed using conventional visual wall motion assessment, longitudinal PSV, and combining the two modalities. Failure of PSV to rise by more than 50% predicted an ischemic response. Significant CAD was defined as luminal stenosis greater than 70%. RESULTS:The number of positive DSE studies according to conventional, PSV, and combined criteria was 41 (30%), 42 (31%), and 46 (34%) respectively. Forty patients (29%) had significant CAD at angiography. The sensitivity, specificity, positive and negative predictive values for conventional DSE analysis were 84, 91, 86, and 90% respectively. The same values for PSV analysis were 86, 92, 86, and 91%, respectively. The same values for the combination of visual and PSV analysis were 88, 94, 87, and 92% respectively. The differences between the three methods were not statistically significant. Sensitivity for single-vessel CAD (P=0.05) and circumflex artery disease (P=0.05) diagnosis was higher with PSV compared with conventional DSE analysis. Failure of PSV to rise by more than 50% during DSE was associated with significantly increased mortality (P=0.001). CONCLUSION:A quantitative interpretation of DSE, based on the percentage rise of PSV during stress, accurately detects CAD and predicts prognosis in end-stage renal disease.


Coron Artery Dis


Coronary artery disease


Sharma R,Mehta RL,Brecker SJ,Gaze DC,Gregson H,Streather CP,Collinson PO,Pellerin D




Has Abstract


2009-05-01 00:00:00














  • Differences in lipoprotein (a) and apolipoprotein (a) levels in men and women with advanced coronary atherosclerosis.

    abstract:BACKGROUND:This study was designed to evaluate whether differences between sexes exist in serum-lipoprotein (a) [Lp(a)] and arterial-wall-apolipoprotein (a) [Apo(a)] levels in patients with advanced coronary artery disease. METHODS:The concentrations of Lp(a) in serum and Apo(a) in aortic biopsies were studied in 76 m...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Stiel GM,Reblin T,Bührlen M,Lattermann A,Nienaber CA

    更新日期:1995-04-01 00:00:00

  • Early versus delayed coronary artery bypass graft surgery for patients with non-ST elevation myocardial infarction.

    abstract:BACKGROUND:Although coronary artery bypass graft surgery (CABG) has been proven to have mortality and morbidity benefits in patients with non-ST elevation myocardial infarction and multivessel disease, the appropriate timing of this procedure remains unclear. Therefore, we proposed a propensity score-matched analysis c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ha LD,Ogunbayo G,Elbadawi A,Olorunfemi O,Messerli A

    更新日期:2017-12-01 00:00:00

  • Role of activation-dependent platelet membrane glycoproteins in development of subacute occlusive coronary stent thrombosis.

    abstract:BACKGROUND:Platelets have an important role in coronary thrombosis. METHODS:We studied 151 consecutive patients undergoing implantation of Palmaz-Schatz stents because of suboptimal results after coronary balloon angioplasty treated by intense anticoagulation. Surface exposure of the constitutively expressed glycoprot...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Gawaz M,Neumann FJ,Ott I,May A,Rüdiger S,Schömig A

    更新日期:1997-03-01 00:00:00

  • The role of Fas in the progression of ischemic heart failure: prohypertrophy or proapoptosis.

    abstract::During myocardial ischemia, cardiomyocytes can undergo apoptosis or compensatory hypertrophy. Fas expression is upregulated in the myocardial ischemia and is coupled to both apoptosis and hypertrophy of cardiomyocytes. The role of Fas in apoptosis induction or cardiomyocyte hypertrophy during ischemic conditions is, h...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Feng QZ,Zhao YS,Abdelwahid E

    更新日期:2008-11-01 00:00:00

  • Variation in plasma platelet-activating factor degradation and serum lipids after acute myocardial infarction.

    abstract:BACKGROUND:Platelet-activating factor is a biologically potent phospholipid that may mediate cell damage in patients with myocardial ischemia. In plasma, its inactivation to lyso-platelet-activating factor is catalyzed by a specific, lipoprotein-associated acetylhydrolase. Because lipoprotein levels decrease after myoc...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Stephens CJ,Graham RM,Sturm MJ,Richardson M,Taylor RR

    更新日期:1993-02-01 00:00:00

  • Characteristics of atherosclerotic plaque distribution in coronary artery bifurcations: an intravascular ultrasound analysis.

    abstract:OBJECTIVE:Vessel bifurcations are prone to atherosclerotic plaque accumulation. Using volumetric intravascular ultrasound analysis, we investigated atheroma distribution at human coronary bifurcations in vivo. METHODS:We analyzed plaque distribution in 49 left anterior descending coronary artery-diagonal and 20 left c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Badak O,Schoenhagen P,Tsunoda T,Magyar WA,Coughlin J,Kapadia S,Nissen SE,Tuzcu EM

    更新日期:2003-06-01 00:00:00

  • Rosuvastatin improves the atherogenic and atheroprotective lipid profiles in patients with hypertriglyceridemia.

    abstract:BACKGROUND:We examined the effects of rosuvastatin treatment on triglyceride levels and lipid measures in a parallel-group multicenter trial (4522IL/0035) in patients with hypertriglyceridemia (Fredrickson Type IIb or IV). METHODS:After a 6-week dietary lead-in period while on a National Cholesterol Education Program ...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Hunninghake DB,Stein EA,Bays HE,Rader DJ,Chitra RR,Simonson SG,Schneck DW

    更新日期:2004-03-01 00:00:00

  • Incidence, treatment, and in-hospital outcome of bifurcation lesions in patients undergoing percutaneous coronary interventions for chronic total occlusions.

    abstract:BACKGROUND:Bifurcation lesions represent a distinct lesion subset associated with an increased risk of procedural complications. Data on the incidence, treatment, and outcome of bifurcation lesions associated with chronic total occlusions are limited. METHODS:Among chronic total occlusion procedures performed by a sin...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Galassi AR,Boukhris M,Tomasello SD,Marzà F,Azzarelli S,Giubilato S,Khamis H

    更新日期:2015-03-01 00:00:00

  • Evaluation of vascular injury following percutaneous transluminal coronary angioplasty: a comparison of the accuracy of two- and three-dimensional intracoronary ultrasound imaging.

    abstract:BACKGROUND:Following percutaneous transluminal coronary angioplasty (PTCA), the extent of vascular injury is underestimated by angiographic assessment. Conventional intracoronary ultrasound (ICUS) imaging provides additional information with regard to the extent of dissections but requires mental reconstruction of cons...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Palmer ND,Lessells A,Northridge DB,Fox KA

    更新日期:2003-05-01 00:00:00

  • Effects of electrode size and spacing on the resolution of intracardiac electrograms.

    abstract:BACKGROUND:Electrogram fractionation can result when multiple groups of cardiac cells are excited asynchronously within the recording region of a mapping electrode. The spatial resolution of an electrode thus plays an important role in mapping complex rhythms. METHODS:We used a computational model, validated against e...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Stinnett-Donnelly JM,Thompson N,Habel N,Petrov-Kondratov V,Correa de Sa DD,Bates JH,Spector PS

    更新日期:2012-03-01 00:00:00

  • Treatment of mild-moderate calcified coronary lesions with sirolimus-eluting stent: real world data from a single center.

    abstract:BACKGROUND:Calcified coronary lesions have commonly been considered as a challenge for interventional cardiologists, and few previous studies of sirolimus-eluting stent (SES) for calcified lesion have been limited by small sample size. Therefore, we evaluated the effectiveness of SES implantation for the treatment of c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yuan JQ,Li JJ,Qin XW,Xu B,Yang YJ,Chen JL,Qiao SB,Ma WH,Yao M,Liu HB,Wu YJ,Chen J,You SJ,Dai J,Xia R,Gao RL

    更新日期:2010-01-01 00:00:00

  • Early versus delayed percutaneous coronary intervention in patients with non-ST elevation acute coronary syndromes.

    abstract:BACKGROUND:The optimal timing of angiography and percutaneous coronary intervention (PCI) in patients with non-ST elevation acute coronary syndromes (NSTEACS) remains uncertain. We sought to assess clinical characteristics and outcomes of patients in real-world contemporary practice who have early versus delayed PCI fo...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Yudi MB,Ajani AE,Andrianopoulos N,Duffy SJ,Farouque O,Ramchand J,Gurvitch R,Lefkovits J,Freeman M,Brennan A,Clark DJ,Reid C,Eccleston D,Melbourne Interventional Group.

    更新日期:2016-08-01 00:00:00

  • Is chronotropic incompetence a limitation in the evaluation of myocardial ischemia and prognosis?

    abstract:OBJECTIVE:The aim of this study was to evaluate whether chronotropic incompetence (CI), the inability to reach 85% of the maximal predicted heart rate during exercise, affects the assessment of myocardial ischemia and prognosis in patients undergoing myocardial perfusion single-photon emission computed tomography (MPS)...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: De Lorenzo A,Oliveira G,Ramos AC,Pinto F,Rothstein T,Lima RS

    更新日期:2014-03-01 00:00:00

  • Variations in lymphocyte activation during exercise testing in patients with coronary artery disease.

    abstract:BACKGROUND:Several studies have shown that strenuous exercise induces changes in the immune system. Soluble interleukin-2 receptor (sIL-2R) is a marker of immune system activation and is known to increase in association with cardiac disease. The aim of the present study was to assess sIL-2R levels in patients with coro...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Zafrir N,Shohat B,Ben-Gal T,Solodky A,Sulkes J,Battler A

    更新日期:2004-06-01 00:00:00

  • Multidetector computed tomography guidance in complex cardiac ablations.

    abstract::Radiofrequency ablation of complex cardiac arrhythmias has undergone significant evolution in the past decade, with the development of technology enabling better anatomic and electrophysiologic mapping of abnormal cardiac tissue. In this paper, we will discuss the role of pre-procedural and post-procedural multidetect...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Lobel RM,Lustgarten DL,Spector PS

    更新日期:2006-03-01 00:00:00

  • Path analysis for key factors influencing long-term quality of life of patients following a percutaneous coronary intervention.

    abstract:OBJECTIVES:This cross-sectional study aimed to investigate the long-term quality of life (QOL) influencing of patients following a percutaneous coronary intervention (PCI) as well as its influencing factors. PATIENTS AND METHODS:From June 2013 to April 2014, 428 PCI patients were enrolled in this questionnaire survey....

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Li L,Wang H,Wang Y,Gao X,Liu G,Zhao Z,Lin P

    更新日期:2019-08-01 00:00:00

  • Comparison of 2-year outcomes of repeated second-generation drug-eluting stent implantation for focal-type versus nonfocal-type in-stent restenosis.

    abstract:BACKGROUND:Second-generation drug-eluting stents (DES) have been used widely to treat DES in-stent restenosis (ISR), which remains a clinical challenge. Knowledge of the outcomes of repeated second-generation DES implantation for focal versus nonfocal-type ISR is still missing. METHODS:In the current study, 254 patien...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Zhu W,Li J,Luo H,Wang G,Hua Q

    更新日期:2015-11-01 00:00:00

  • Reduced low-frequency heart rate variability relates to greater intimal-medial thickness of the carotid wall in two samples.

    abstract:INTRODUCTION:We investigated the relationship between heart rate variability and preclinical carotid intima-media thickening, a putative index of atherosclerosis. METHODS:A sample of 350 men and women (mean age 56.8 years) selected for the presence or absence of untreated hypertension was assessed for heart rate varia...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Gautier C,Stine L,Jennings JR,Sutton-Tyrrell K,Muldoon MB,Kamarck TW,Kaplan GA,Salonen J,Manuck SB

    更新日期:2007-03-01 00:00:00

  • Safety and efficacy of transradial versus transfemoral percutaneous coronary intervention in acute myocardial infarction: a meta-analysis of randomized trials.

    abstract:BACKGROUND:The transradial approach has gained increasing popularity for elective percutaneous coronary intervention. However, the safety and feasibility of transradial coronary intervention (TRI) in acute myocardial infarction (AMI) remains uncertain. Hence, a meta-analysis of randomized trials was performed to compar...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,meta分析


    authors: Singh PP,Singh M,Khosla N,Shah T,Molnar J,Arora R,Khosla S

    更新日期:2012-06-01 00:00:00

  • Atrial fibrillation, bleeding, and coronary intervention: current recommendations.

    abstract::The patient population with the need for oral anticoagulation to reduce stroke risk associated with atrial fibrillation (AF) and dual antiplatelet therapy to prevent stent thrombosis and myocardial infarction after percutaneous coronary intervention is increasing. However, patients treated with a triple therapy consis...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Farhan S,Mehran R

    更新日期:2017-12-01 00:00:00

  • Coronary intervention for chronic total occlusion: current indications and future directions.

    abstract::Chronic total occlusions (CTOs) are routinely encountered during coronary angiography, but subsequent revascularization rates are low. This has likely been driven by a historical belief that there is minimal clinical benefit and poor success rates with a percutaneous coronary intervention (PCI). However, in the curren...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Sathananthan J,Džavík V

    更新日期:2017-08-01 00:00:00

  • Serum levels of YKL-40 increases in patients with acute myocardial infarction.

    abstract:OBJECTIVES:YKL-40 is secreted by macrophages, including those in atherosclerotic plaques, neutrophils, and vascular smooth muscle cells. Circulating YKL-40 is elevated in patients with inflammation and increased tissue remodeling. The aim was to examine the sequential changes in serum YKL-40 in patients with acute myoc...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Nøjgaard C,Høst NB,Christensen IJ,Poulsen SH,Egstrup K,Price PA,Johansen JS

    更新日期:2008-06-01 00:00:00

  • Plasma soluble adhesion molecules; intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin levels in patients with isolated coronary artery ectasia.

    abstract:UNLABELLED:Plasma soluble adhesion molecules, intercellular adhesion molecule-1 (ICAM)-1, vascular cell adhesion molecule-1 (VCAM-1) and E-selectin leves of patients with isolated coronary artery ectasia (CAE), patients with obstructive coronary artery disease without CAE and subjects with angiographically normal coron...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Turhan H,Erbay AR,Yasar AS,Aksoy Y,Bicer A,Yetkin G,Yetkin E

    更新日期:2005-02-01 00:00:00

  • Dimensions and anatomic variations of left main coronary artery in normal population: multidetector computed tomography assessment.

    abstract:OBJECTIVES:The aim of our study was to determine the dimensions, morphology and anatomic variations of the left main coronary artery (LMCA) in normal participants, on multidetector computed tomography. BACKGROUND:Accurate imaging of LMCA dimensions and configuration is crucial to avoid misdiagnosis of LMCA disease. M...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Zeina AR,Rosenschein U,Barmeir E

    更新日期:2007-09-01 00:00:00

  • The antiarrhythmic effect and clinical consequences of ischemic preconditioning.

    abstract::Potentially hazardous short ischemic episodes increase the tolerance of myocardium to ischemia paradoxically. This condition decreases the infarct area markedly caused by a longer duration of coronary occlusion. This phenomenon is known as 'ischemic preconditioning' and its powerful cardioprotective effect has been sh...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Evrengul H,Seleci D,Tanriverdi H,Kaftan A

    更新日期:2006-05-01 00:00:00

  • Risk stratification for malignant arrhythmic events in patients with an acute myocardial infarction: role of an open infarct-related artery and the signal-averaged ECG.

    abstract:BACKGROUND:There is increasing evidence that an open infarct-related artery results in increased electrical stability of the heart and that this effect is at least in part responsible for the favorable outcome of these patients. In the thrombolytic era the optimal strategy for risk stratification remains controversial....

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Hermosillo AG,Araya V,Casanova JM

    更新日期:1995-12-01 00:00:00

  • Decreased carotid intima-media thickness in patients with coronary artery ectasia compared with patients with coronary artery disease.

    abstract:BACKGROUND:Although atherosclerosis is supposed to be responsible for more than 50% of coronary artery ectasia, the precise pathology of coronary artery ectasia is not clearly understood. A histopathological examination of ectatic segments has revealed mainly destruction of the media layer of the artery. In the present...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yetkin E,Acikgoz N,Aksoy Y,Bariskaner E,Sivri N,Akturk E,Turhan H,Kosar F,Cehreli S

    更新日期:2005-12-01 00:00:00

  • Systolic hypertension in older patients: are calcium channel antagonists safe?

    abstract::The Editor and Associate Editors are pleased that our readership will have the opportunity to benefit from a series of contributions by Dr John Rutherford addressing current issues in pharmacology and therapeutics pertinent to coronary artery disease. We are pleased also that Dr Rutherford will provide authoritative p...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Rutherford JD

    更新日期:2000-12-01 00:00:00

  • The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age.

    abstract:OBJECTIVE:To examine the contribution of six cardiovascular polymorphisms to the occurrence of a first event of ischemic heart disease (IHD) in a primary care population with a high prevalence of hypertension. Furthermore, we specified the data for sex and age. METHODS:In this cross sectional case-control study, patie...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Plat AW,Stoffers HE,de Leeuw PW,van Schayck CP,Soomers FL,Kester AD,Aretz K,Kroon AA

    更新日期:2009-12-01 00:00:00

  • Low-pressure deployment of stents: short- and long-term outcome.

    abstract::This study investigates a strategy of low-pressure stenting with concomitant anti-platelet treatment designed to prevent short- and long-term events after stenting. Ninety consecutive patients who underwent percutaneous transluminal coronary angioplasty with stenting using low-pressure stent deployment (mean 8.1 atmos...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Cafri C,Weinstein JM,Gilutz H,Kobal S,Ilia R

    更新日期:2001-06-01 00:00:00