Abstract:
OBJECTIVE:To determine whether a quantitative measurement of peak systolic velocity (PSV) during dobutamine stress echocardiography (DSE) detects severe coronary artery disease (CAD) and predicts mortality in patients with end-stage renal disease. METHODS:One hundred and forty renal transplant candidates had DSE and coronary angiography. DSE analysis was performed using conventional visual wall motion assessment, longitudinal PSV, and combining the two modalities. Failure of PSV to rise by more than 50% predicted an ischemic response. Significant CAD was defined as luminal stenosis greater than 70%. RESULTS:The number of positive DSE studies according to conventional, PSV, and combined criteria was 41 (30%), 42 (31%), and 46 (34%) respectively. Forty patients (29%) had significant CAD at angiography. The sensitivity, specificity, positive and negative predictive values for conventional DSE analysis were 84, 91, 86, and 90% respectively. The same values for PSV analysis were 86, 92, 86, and 91%, respectively. The same values for the combination of visual and PSV analysis were 88, 94, 87, and 92% respectively. The differences between the three methods were not statistically significant. Sensitivity for single-vessel CAD (P=0.05) and circumflex artery disease (P=0.05) diagnosis was higher with PSV compared with conventional DSE analysis. Failure of PSV to rise by more than 50% during DSE was associated with significantly increased mortality (P=0.001). CONCLUSION:A quantitative interpretation of DSE, based on the percentage rise of PSV during stress, accurately detects CAD and predicts prognosis in end-stage renal disease.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Sharma R,Mehta RL,Brecker SJ,Gaze DC,Gregson H,Streather CP,Collinson PO,Pellerin Ddoi
10.1097/MCA.0b013e32832ac5ebsubject
Has Abstractpub_date
2009-05-01 00:00:00pages
230-7issue
3eissn
0954-6928issn
1473-5830pii
00019501-200905000-00009journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Low-molecular-weight heparins may have a higher benefit to risk ratio than unfractionated heparin in preventing perioperative thrombosis. The antithrombotic effects of low-molecular-weight heparins, given as adjunctive therapy to alteplase and aspirin, have not previously been compared with those of unfracti...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::The risk of cardiovascular events in patients with diabetes is similar to that of patients with previous history of ischaemic heart disease and the prevalence of ischaemic heart disease complicating diabetic syndromes is growing rapidly. Management of ischaemic heart disease in diabetic patients remains a challenge. T...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/00019501-200511001-00005
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:17 beta-Estradiol and phytoestrogens are known to have beneficial effects on the cardiovascular systems of women. The exact mechanisms for how estrogens and phytoestrogens influence the cardiovascular system are not yet understood in detail. OBJECTIVE:The objective of this study was to investigate whether 1...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199912000-00010
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:The optimal timing of angiography and percutaneous coronary intervention (PCI) in patients with non-ST elevation acute coronary syndromes (NSTEACS) remains uncertain. We sought to assess clinical characteristics and outcomes of patients in real-world contemporary practice who have early versus delayed PCI fo...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0000000000000374
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Apoptotic cell death is the major form of myocardial damage produced by coronary ischemic events. OBJECTIVE:To assess whether circulating levels of soluble Fas (sFas), an inhibitor of apoptosis, and sFas ligand, an inducer of apoptosis, in patients with coronary artery disease are greater than normal. METH...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199906000-00003
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVES:We analyzed a large patient group to develop a clinical risk score that could be applied to patients after primary percutaneous coronary intervention (PCI). METHODS:We reviewed 2529 consecutive patients treated with primary PCI for ST-elevation myocardial infarction between 2003 and 2008. All clinical, angi...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328333f528
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To prospectively compare iopamidol 370, which is a low-osmolar contrast medium and iodixanol 320, which is an iso-osmolar contrast medium, in terms of image quality and nonserious adverse effects that have the potential to influence the image quality in a 16-slice multi-detector row computed tomography corona...
journal_title:Coronary artery disease
pub_type: 杂志文章,随机对照试验
doi:10.1097/MCA.0b013e328338cd0b
更新日期:2010-11-01 00:00:00
abstract::Radiofrequency ablation of complex cardiac arrhythmias has undergone significant evolution in the past decade, with the development of technology enabling better anatomic and electrophysiologic mapping of abnormal cardiac tissue. In this paper, we will discuss the role of pre-procedural and post-procedural multidetect...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/00019501-200603000-00005
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:Noninvasive flow-mediated vasodilation (FMD) is a widely used method to assess endothelial function, but its technical difficulty and problems remain obstacles for use in clinical practice. Reactive hyperemia-peripheral arterial tonometry (RH-PAT) was developed as a simpler and more reproducible method. We co...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000094
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:A more sensitive transthoracic color Doppler technology (convergent color Doppler), along with a heart rate (HR) reduction and new tomographic planes, can greatly improve coronary blood flow velocity (BFV) recordings in the left main (LMCA) and left anterior descending (LAD) coronary arteries, allowing the d...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000873
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Bifurcation lesions represent a distinct lesion subset associated with an increased risk of procedural complications. Data on the incidence, treatment, and outcome of bifurcation lesions associated with chronic total occlusions are limited. METHODS:Among chronic total occlusion procedures performed by a sin...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000194
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION:The serum level of parathyroid hormone (PTH) has been shown to be a predictor of cardiovascular mortality. Data on the association between PTH level and degree of atherosclerosis severity are lacking. The objective of this study was to determine the relationship of serum PTH level and number of stenotic co...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000089
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:With new interventions minimizing ischemic myocardial injury, accurate and reliable techniques for the detection and continuous monitoring of myocardial ischemia are essential. We compared two techniques used for the detection of myocardial ischemia during coronary angioplasty: on-line computerized vectorcar...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:Several studies have shown that strenuous exercise induces changes in the immune system. Soluble interleukin-2 receptor (sIL-2R) is a marker of immune system activation and is known to increase in association with cardiac disease. The aim of the present study was to assess sIL-2R levels in patients with coro...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:We investigated whether diffuse coronary vasoconstriction induced by acetylcholine caused myocardial ischemia. METHODS:We studied 30 patients (40 coronary arteries) with spontaneous chest pain or equivocal studies on treadmill exercise testing and no significant coronary stenosis or previous myocardial infa...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::This review provides a brief introduction to the basic concepts of MRA techniques with specific discussions on imaging of coronary arteries. These techniques, especially those for imaging of coronary arteries, are still rapidly evolving. The goals of future research include obtaining faster imaging, higher SNR, and hi...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/00019501-199905000-00002
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:Although atherosclerosis is supposed to be responsible for more than 50% of coronary artery ectasia, the precise pathology of coronary artery ectasia is not clearly understood. A histopathological examination of ectatic segments has revealed mainly destruction of the media layer of the artery. In the present...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200512000-00007
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVES:Recent studies have reported a strong independent association between increased red cell distribution width (RDW) and the risk of adverse outcomes in patients with heart failure, stable coronary disease, and acute coronary syndromes. However, in this study we aimed to determine the impact of an elevated RDW ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3283587897
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:Red cell distribution width (RDW), a measure of red blood cell size heterogeneity, was evaluated in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Higher RDW is associated with mortality in patients with symptomatic car...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328342c77b
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:The failure of reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI) is more frequent than considered previously. AIM:To evaluate sex-related differences in long-term outcomes in patients with STEMI and incomplete infarct-related artery reperfusion after a primary percutane...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0000000000000703
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:This cross-sectional study aimed to investigate the long-term quality of life (QOL) influencing of patients following a percutaneous coronary intervention (PCI) as well as its influencing factors. PATIENTS AND METHODS:From June 2013 to April 2014, 428 PCI patients were enrolled in this questionnaire survey....
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000712
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Restenosis after coronary angioplasty is considered to be caused mainly by increased migration and proliferation of smooth muscle cells (SMC). The concept of local, site-specific delivery of pharmacologic therapies has opened the door for new, high-dose drug regimes. METHODS AND RESULTS:SMC were isolated by...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199703000-00011
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the association of widowhood with the severity and extent of coronary artery disease (CAD), and whether it is modified by sex or socioeconomic status. PATIENTS AND METHODS:A total of 1068 patients undergoing coronary angiography at five centers in Saudi Arabia and the Uni...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0000000000000436
更新日期:2017-03-01 00:00:00
abstract:AIM:The aim of this study was to assess the effect on adherence to statin therapy and assess the effect of beneficial changes in behavior that resulted in weight loss in patients who underwent coronary artery calcium (CAC) scoring with cardiac computed tomography. BACKGROUND:Despite convincing data demonstrating the b...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000207
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:Coronary artery bypass graft (CABG) surgery has been a mainstream surgical procedure for coronary artery disease for the past three decades. 64-Slice coronary computed tomographic angiography (CCTA) has been established as an accurate alternative to invasive coronary artery angiography for postoperative evalu...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32834b830e
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to describe the procedural characteristics, myocardial perfusion, and long-term outcomes in ST-elevation myocardial infarction patients with an ectatic infarct-related artery (IRA). PATIENTS AND METHODS:The retrospective analysis included 1270 consecutive ST-elevation myocardial inf...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000720
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Baseline coronary artery diameter and coronary artery dilation response to nitrate are associated with coronary vasoreactivity. OBJECTIVES:The present study investigated the predictive value of coronary artery tone for a positive intracoronary acetylcholine (ACh) provocation test. METHODS:A total of 197 pa...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000401
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:K1K2Pu is a recombinant chimeric tissue-type and urokinase-type plasminogen activator consisting of the two kringle domains (K1 and K2) of human tissue-type plasminogen activator (t-PA) and the serine proteinase domain (Pu) of single-chain urokinase-type plasminogen activator (scu-PA). In experimental animal...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199310000-00013
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Previous studies have suggested an increased risk of myocardial infarction associated with physical exercise. Activated neutrophils may contribute to the triggering mechanisms. METHODS:Fifteen patients with stable angina pectoris underwent symptom-limited bicycle ergometry. In neutrophils obtained from seri...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::Potentially hazardous short ischemic episodes increase the tolerance of myocardium to ischemia paradoxically. This condition decreases the infarct area markedly caused by a longer duration of coronary occlusion. This phenomenon is known as 'ischemic preconditioning' and its powerful cardioprotective effect has been sh...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/00019501-200605000-00013
更新日期:2006-05-01 00:00:00