Serum gamma-glutamyl transferase activity increased in patients with coronary artery ectasia.

Abstract:

BACKGROUND:Serum gamma-glutamyl transferase (GGT) activity, an enzyme responsible for the extracellular catabolism of antioxidant glutathione, may directly take part in atherogenesis and evolve as a potential biochemical risk indicator of cardiovascular morbidity and mortality. An important characteristic of coronary artery ectasia (CAE) is the fact that in 85% of the cases, atherosclerotic coronary disease accompanies it. The relation between CAE and serum GGT activity has not been studied so far. Hence, we decided to investigate the serum GGT level in patients with CAE. METHODS:We measured serum GGT activity in 88 consecutive patients (48 males) with isolated CAE and 86 patients with coronary artery disease (CAD) and 84 controls. CAE was defined as being without any stenotic lesions with a visual assessment of the coronary arteries showing a luminal dilatation 1.5-fold or more of the adjacent normal coronary segments. Four subgroups were created in accordance with the CAE extension in coronary arteries. RESULTS:There were no statistically significant differences in serum GGT activity among CAE and CAD groups. Serum GGT activity was found significantly increased in patients in both CAE and CAD groups, compared with those in control group (P<0.001, P<0.001, respectively). According to the CAE severity, there were no statistically significant differences in CAE among these subgroups. CONCLUSION:We have shown for the first time that patients with CAE have higher serum GGT activity compared with controls with normal coronary angiograms. Hence, serum GGT activity can be used as a follow-up marker in patients with CAE.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Sen N,Basar N,Maden O,Ozcan F,Ozlu MF,Gungor O,Turak O,Malcok O,Atak R,Demir AD,Balbay Y

doi

10.1097/MCA.0b013e32830eaba1

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

455-8

issue

7

eissn

0954-6928

issn

1473-5830

pii

00019501-200811000-00005

journal_volume

19

pub_type

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