Statins and myocardial hypertrophy.

Abstract:

:Cardiac hypertrophy is a physiological adaptive response by the heart to pressure overload. However, after prolonged periods, this initial adaptive response becomes maladaptive, leading to increased mortality and morbidity from heart failure. Recently, 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, have been shown to inhibit cardiac hypertrophy by cholesterol-independent mechanisms. Statins block the isoprenylation and activation of members of the Rho guanosine triphosphatase (GTPase) family, such as RhoA and Rac1. Since Rac1 is a requisite component of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which is a major source of reactive oxygen species (ROS) in cardiovascular cells, the ability of statins to inhibit Rac1-mediated oxidative stress makes an important contribution to their inhibitory effects on cardiac hypertrophy.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Nakagami H,Liao JK

doi

10.1097/01.mca.0000130229.18685.b9

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

247-50

issue

5

eissn

0954-6928

issn

1473-5830

pii

00019501-200408000-00005

journal_volume

15

pub_type

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