The antiarrhythmic effect and clinical consequences of ischemic preconditioning.

Abstract:

:Potentially hazardous short ischemic episodes increase the tolerance of myocardium to ischemia paradoxically. This condition decreases the infarct area markedly caused by a longer duration of coronary occlusion. This phenomenon is known as 'ischemic preconditioning' and its powerful cardioprotective effect has been shown in experimental and clinical studies. Ischemic preconditioning decreases cardiac mortality markedly by preventing the development of left ventricular dysfunction and ventricular and supraventricular arrhythmias after acute myocardial infarction. Ischemia-induced opening of ATP-sensitive potassium channels and synthesis of stress proteins via activation of adenosine, bradykinin and prostaglandin receptors seem to be the possible mechanisms. By understanding the underlying mechanisms of ischemic preconditioning, it may be possible to develop new pharmacologic agents that cause ischemic preconditioning with antiischemic and antiarrhythmic properties without causing myocardial ischemia.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Evrengul H,Seleci D,Tanriverdi H,Kaftan A

doi

10.1097/00019501-200605000-00013

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

283-8

issue

3

eissn

0954-6928

issn

1473-5830

pii

00019501-200605000-00013

journal_volume

17

pub_type

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