The antiarrhythmic effect and clinical consequences of ischemic preconditioning.


:Potentially hazardous short ischemic episodes increase the tolerance of myocardium to ischemia paradoxically. This condition decreases the infarct area markedly caused by a longer duration of coronary occlusion. This phenomenon is known as 'ischemic preconditioning' and its powerful cardioprotective effect has been shown in experimental and clinical studies. Ischemic preconditioning decreases cardiac mortality markedly by preventing the development of left ventricular dysfunction and ventricular and supraventricular arrhythmias after acute myocardial infarction. Ischemia-induced opening of ATP-sensitive potassium channels and synthesis of stress proteins via activation of adenosine, bradykinin and prostaglandin receptors seem to be the possible mechanisms. By understanding the underlying mechanisms of ischemic preconditioning, it may be possible to develop new pharmacologic agents that cause ischemic preconditioning with antiischemic and antiarrhythmic properties without causing myocardial ischemia.


Coron Artery Dis


Coronary artery disease


Evrengul H,Seleci D,Tanriverdi H,Kaftan A




Has Abstract


2006-05-01 00:00:00














  • Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction.

    abstract:OBJECTIVES:Red cell distribution width (RDW), a measure of red blood cell size heterogeneity, was evaluated in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Higher RDW is associated with mortality in patients with symptomatic car...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Uyarel H,Ergelen M,Cicek G,Kaya MG,Ayhan E,Turkkan C,Yıldırım E,Kırbas V,Onturk ET,Erer HB,Yesilcimen K,Gibson CM

    更新日期:2011-05-01 00:00:00

  • Women react with more myocardial ischemia and angina pectoris during elective percutaneous transluminal coronary angioplasty.

    abstract:BACKGROUND:Women have been considered to be at higher risk of complications relating to percutaneous transluminal coronary angioplasty (PTCA) than are men. One reason for this sex-related difference could be the ischemic response of myocardium during the procedure. OBJECTIVE:To investigate whether there are sex-relate...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Jensen J,Eriksson SV,Lindvall B,Lundin P,Sylven C

    更新日期:2000-10-01 00:00:00

  • Invasive assessment of microvascular function in patients with valvular heart disease.

    abstract:BACKGROUND:The aim of this study was to investigate microvascular function in patients with valvular heart disease (VHD), which causes chronic left ventricular volume and/or pressure overload, therefore change in coronary microvascular hemodynamics. PATIENTS AND METHODS:We prospectively enrolled 30 patients with VHD c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Nishi T,Kitahara H,Saito Y,Nishi T,Nakayama T,Fujimoto Y,Matsumiya G,Kobayashi Y

    更新日期:2018-05-01 00:00:00

  • The relative rapidity of recanalization induced by recombinant tissue-type plasminogen activator (r-tPA) and TNK-tPA, assessed with enzymatic methods.

    abstract:BACKGROUND:Comparison of different plasminogen activators is difficult because conventional endpoints such as mortality are relatively insensitive to potential differences in efficacy with respect to rapidity of recanalization of infarct-related arteries. METHODS:This study was performed to determine whether valid com...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Binbrek A,Rao N,Absher PM,Van de Werf F,Sobel BE

    更新日期:2000-07-01 00:00:00

  • Effect of angiotensin-converting enzyme inhibitors on the power spectrum of heart rate variability in post-myocardial infarction patients.

    abstract:BACKGROUND:Heart rate variability (HRV) time and frequency domain indices are strong predictors of malignant arrhythmias and sudden cardiac death. The effect of various angiotensin-converting enzyme (ACE) inhibitors on HRV in patients with acute myocardial infarction (AMI) has not been studied. METHODS:Ninety patients...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kontopoulos AG,Athyros VG,Papageorgiou AA,Skeberis VM,Basayiannis EC,Boudoulas H

    更新日期:1997-08-01 00:00:00

  • Correlation between coronary artery calcium score and aortic diameter in a high-risk population of elderly male hypertensive patients.

    abstract:BACKGROUND:Studies on the relationship between coronary artery calcium and aortic diameter are scarce. The aim of the current study was to evaluate the correlation between coronary artery calcium score (CACS) and maximal thoracic and abdominal aortic diameters in a population of elderly (>65 years) male hypertensive pa...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Cho IJ,Heo R,Chang HJ,Shin S,Shim CY,Hong GR,Min JK,Chung N

    更新日期:2014-12-01 00:00:00

  • Postprandial hypertriglyceridemia associated with inflammatory response and procoagulant state after a high-fat meal in hypertensive patients.

    abstract:OBJECTIVE:To investigate the changes of inflammatory factors and hemostatic variable in plasma after a high-fat meal in normocholesterolemic patients with essential hypertension. METHODS:A total of 60 hypertensive patients were randomly assigned to accept a single high-fat meal (group 1, n=40) or not (group 2, n=20) i...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Liu L,Zhao SP,Wen T,Zhou HN,Hu M,Li JX

    更新日期:2008-05-01 00:00:00

  • Single nucleotide polymorphisms associated with abnormal coronary microvascular function.

    abstract:BACKGROUND:Single nucleotide polymorphisms (SNPs) are the most common source of genetic variation. Although microvascular pathology is associated with cardiovascular events, genetic phenotypes causing microvascular disease remain largely unknown. This study identifies sex-specific SNPs associated with coronary microvas...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yoshino S,Cilluffo R,Best PJ,Atkinson EJ,Aoki T,Cunningham JM,de Andrade M,Choi BJ,Lerman LO,Lerman A

    更新日期:2014-06-01 00:00:00

  • Tako-tsubo cardiomyopathy and coronary artery disease: a possible association.

    abstract:BACKGROUND:In the medical literature, several cases of Tako-tsubo cardiomyopathy (TTC) with coronary artery disease (CAD) have been reported, and in clinical practice, several typical TTC cases show relevant stenoses of the coronary arteries spatially unrelated to the dysfunctional myocardium. OBJECTIVE:This study aim...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Parodi G,Citro R,Bellandi B,Del Pace S,Rigo F,Marrani M,Provenza G,Leoncini M,Salerno Uriarte JA,Bovenzi F,Bossone E,Tako-tsubo Italian Network (TIN).

    更新日期:2013-09-01 00:00:00

  • The effect of low FT3 levels on coronary artery calcification and MACE in outpatients with suspected coronary artery disease.

    abstract:OBJECTIVE:Considerable evidence suggests that thyroid dysfunction, especially hypothyroidism, may lead to coronary artery disease (CAD). The aim of this study is to investigate the effect of low serum levels of free triiodothyronine (FT3) on coronary artery calcification in outpatients with suspected CAD and the occurr...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Zhu L,Gao C,Wang X,Qi D,Zhang Y,Li M,Liu W,Hao P

    更新日期:2014-08-01 00:00:00

  • Assessment of tissue characteristics of noncalcified coronary plaques by 64-slice computed tomography in comparison with integrated backscatter intravascular ultrasound.

    abstract:BACKGROUND:The ability of 64-slice computed tomography (CT) angiography to differentiate plaque types remains unclear. We evaluated whether the density of noncalcified coronary plaques by 64-slice CT angiography correlates with plaque components assessed by integrated backscatter intravascular ultrasound (IB-IVUS). ME...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yang WI,Hur J,Ko YG,Choi BW,Kim JS,Choi D,Ha JW,Hong MK,Jang Y,Chung N,Shim WH,Cho SY

    更新日期:2010-05-01 00:00:00

  • Head-to-head comparison between technetium-99m-sestamibi and thallium-201 tomographic imaging for the detection of coronary artery disease using combined dipyridamole-exercise stress.

    abstract:AIM:The purpose of this study was a head-to-head comparison of tomographic imaging (SPECT) with technetium-99m (Tc-99m)-sestamibi and thallium-201 (Tl-201) using dipyridamole-low-level bicycle exercise stress for the assessment of coronary artery disease. METHODS:We studied 38 consecutive patients referred for the eva...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cramer MJ,Verzijlbergen JF,Van der Wall EE,Niemeyer MG,Zwinderman AH,Ascoop CA,Pauwels EJ

    更新日期:1994-09-01 00:00:00

  • Effects of electrode size and spacing on the resolution of intracardiac electrograms.

    abstract:BACKGROUND:Electrogram fractionation can result when multiple groups of cardiac cells are excited asynchronously within the recording region of a mapping electrode. The spatial resolution of an electrode thus plays an important role in mapping complex rhythms. METHODS:We used a computational model, validated against e...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Stinnett-Donnelly JM,Thompson N,Habel N,Petrov-Kondratov V,Correa de Sa DD,Bates JH,Spector PS

    更新日期:2012-03-01 00:00:00

  • Elderly patients with hypercholesterolaemia: a double-blind study of the efficacy, safety and tolerability of fluvastatin.

    abstract:BACKGROUND:Coronary heart disease is a major cause of morbidity and mortality in the elderly, a rapidly growing section of the population. Elderly patients have been excluded from most preventative risk factor trials. METHODS:We evaluated fluvastatin, a fully synthetic hydroxymethyl glutaryl coenzyme A reductase inhib...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Lye M,Valacio R,Reckless JP,Ghosh AK,Findlay IN,Ghosh MK,Passmore AP,Fulcher RA

    更新日期:1998-01-01 00:00:00

  • Prevalence and severity of abnormal glucose regulation and its relation to long-term prognosis after coronary artery bypass grafting.

    abstract:BACKGROUND:Diabetes is a strong predictor of a poor outcome after coronary artery bypass grafting (CABG). The prevalence of prediabetes and its impact on the prognosis after CABG is not well described. In this study, we evaluated the prevalence and prognostic impact of the different states of abnormal glucose regulatio...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Petursson P,Herlitz J,Lindqvist J,Sjöland H,Gudbjörnsdottir S

    更新日期:2013-11-01 00:00:00

  • Antibodies to oxidized low-density lipoprotein in patients following coronary artery revascularization.

    abstract:BACKGROUND:Measurement of antibodies to oxidized low-density lipoprotein (AB-oxLDL) has been proposed as a way of identifying individuals at risk for cardiovascular disease beyond the determination of LDL cholesterol (LDL-c) alone. While this hypothesis is appealing, evidence that AB-oxLDL is a risk factor independent ...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Miller ER 3rd,Erlinger TP,Blumenthal RS,Margolis S,Allen JK

    更新日期:2003-04-01 00:00:00

  • Acute cardiorenal anemia syndrome among ST-elevation myocardial infarction patients treated by primary percutaneous intervention.

    abstract:BACKGROUND:Acute kidney injury (AKI) and anemia have been extensively studied in ST-elevation myocardial infarction (STEMI), yet the precise nature of their reciprocal relationship has not been elucidated in STEMI patients. METHODS:We performed a retrospective analysis of 2096 consecutive patients admitted for STEMI b...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Merdler I,Loewenstein I,Zahler D,Levit D,Hochstadt A,Banai S,Gal-Oz A,Shacham Y

    更新日期:2020-10-13 00:00:00

  • The effect of glucose-insulin-potassium solution on ventricular late potentials and heart rate variability in acute myocardial infarction.

    abstract:BACKGROUND:Blunted heart rate variability (HRV) and presence of ventricular late potentials (VLPs) are known to correlate with an increased risk of ventricular tachycardia and sudden cardiac death in acute myocardial infarction (AMI). In the present study, we investigated the effect of glucose-insulin-potassium (GIK) s...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ulgen MS,Alan S,Akdemir O,Toprak N

    更新日期:2001-09-01 00:00:00

  • Single-dose intramuscular administration of sustained-release Angiopeptin reduces neointimal hyperplasia in a porcine coronary in-stent restenosis model.

    abstract:BACKGROUND:In-stent restenosis results primarily from neointimal hyperplasia. In a previous study we showed that continuous subcutaneous Angiopeptin infusion for 1 week significantly reduces neointimal hyperplasia in a porcine coronary overstretch in-stent restenosis model. The present study evaluated the relative effi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Hong MK,Kent KM,Tio FO,Foegh M,Kornowski R,Bramwell O,Cathapermal SS,Leon MB

    更新日期:1997-02-01 00:00:00

  • The surgical management of congenital coronary artery fistula.

    abstract:BACKGROUND:Congenital coronary artery fistula (CAF) is a very rare cardiovascular anomaly and only 400 cases have been reported. The purpose of this study was to analyse the experience of surgical treatments in CAF and evaluate the surgical indications, techniques and long-term results. METHODS:A retrospective study r...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Chen Y,Belboul A,Roberts D

    更新日期:1994-12-01 00:00:00

  • Thrombomodulin -33G/A and Ala455Val polymorphisms are associated with the risk of coronary artery disease: a meta-analysis including 12 584 patients.

    abstract:BACKGROUND:Thrombomodulin (TM) -33G/A and Ala455Val polymorphisms have been indicated to be correlated with the risk of coronary artery disease (CAD), but study results are still inclusive. Thus, a meta-analysis was carried out. MATERIALS AND METHODS:Databases including PubMed, Embase, CNKI, and Web of Science (ISI) w...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,meta分析,评审


    authors: Wang H,Dong P

    更新日期:2015-01-01 00:00:00

  • Long-term outcomes in men and women with ST-segment elevation myocardial infarction and incomplete reperfusion after a primary percutaneous coronary intervention: a 2-year follow-up.

    abstract:BACKGROUND:The failure of reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI) is more frequent than considered previously. AIM:To evaluate sex-related differences in long-term outcomes in patients with STEMI and incomplete infarct-related artery reperfusion after a primary percutane...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Zachura M,Wilczek K,Janion M,Gąsior M,Gierlotka M,Sadowski M

    更新日期:2019-05-01 00:00:00

  • Preconditioning effects of adenosine in patients with severe coronary artery disease but preserved coronary flow reserve.

    abstract:BACKGROUND:Adenosine plays a key role in different protective and adaptive responses to ischemia and has been suggested to induce ischemic preconditioning. AIM:To investigate whether a low-dose adenosine infusion reduces the ischemic burden induced by pharmacological stress without affecting the coronary flow reserve ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,随机对照试验


    authors: Sadigh B,Shahgaldi K,Sylvén C,Quintana M,Winter R

    更新日期:2009-08-01 00:00:00

  • Neutrophil hyper-reactivity after exercise-induced angina pectoris.

    abstract:BACKGROUND:Previous studies have suggested an increased risk of myocardial infarction associated with physical exercise. Activated neutrophils may contribute to the triggering mechanisms. METHODS:Fifteen patients with stable angina pectoris underwent symptom-limited bicycle ergometry. In neutrophils obtained from seri...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ott I,Neumann FJ,Schömig A

    更新日期:1995-07-01 00:00:00

  • The association of serum parathyroid hormone and severity of coronary artery diseases.

    abstract:INTRODUCTION:The serum level of parathyroid hormone (PTH) has been shown to be a predictor of cardiovascular mortality. Data on the association between PTH level and degree of atherosclerosis severity are lacking. The objective of this study was to determine the relationship of serum PTH level and number of stenotic co...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Shekarkhar S,Foroughi M,Moatamedi M,Gachkar L

    更新日期:2014-06-01 00:00:00

  • The diagnostic and prognostic value of tissue Doppler imaging during dobutamine stress echocardiography in end-stage renal disease.

    abstract:OBJECTIVE:To determine whether a quantitative measurement of peak systolic velocity (PSV) during dobutamine stress echocardiography (DSE) detects severe coronary artery disease (CAD) and predicts mortality in patients with end-stage renal disease. METHODS:One hundred and forty renal transplant candidates had DSE and c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Sharma R,Mehta RL,Brecker SJ,Gaze DC,Gregson H,Streather CP,Collinson PO,Pellerin D

    更新日期:2009-05-01 00:00:00

  • Relationship of blood cholesterol and apoprotein B levels to angiographically defined coronary artery disease in young males.

    abstract:BACKGROUND:Coronary heart disease is mainly caused by the effects of obstruction to blood flow in the coronary arteries from discrete mural lesions that encroach into the lumen and usually occur in arteries that are involved by atherosclerosis. Even though the level of certain lipoproteins is indisputably related to th...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: McGill DA,Talsma P,Ardlie NG

    更新日期:1993-03-01 00:00:00

  • Reduced low-frequency heart rate variability relates to greater intimal-medial thickness of the carotid wall in two samples.

    abstract:INTRODUCTION:We investigated the relationship between heart rate variability and preclinical carotid intima-media thickening, a putative index of atherosclerosis. METHODS:A sample of 350 men and women (mean age 56.8 years) selected for the presence or absence of untreated hypertension was assessed for heart rate varia...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Gautier C,Stine L,Jennings JR,Sutton-Tyrrell K,Muldoon MB,Kamarck TW,Kaplan GA,Salonen J,Manuck SB

    更新日期:2007-03-01 00:00:00

  • Culprit versus multivessel coronary intervention in ST-segment elevation myocardial infarction: a meta-analysis of randomized trials.

    abstract:BACKGROUND:The 2015 American College of Cardiology/American Heart Association update on primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) recommended PCI of the non-infarct-related artery at the time of primary PCI (class IIb recommendation). Despite ev...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,meta分析


    authors: Vaidya SR,Qamar A,Arora S,Devarapally SR,Kondur A,Kaul P

    更新日期:2018-03-01 00:00:00

  • Immediate effect of Biosense guided percutaneous direct myocardial revascularization with holmium:yttrium aluminium garnet laser on myocardial contractility assessed by transesophageal echocardiography.

    abstract:OBJECTIVE:To evaluate immediate changes in left ventricular wall motion in patients treated using Biosense direct myocardial revascularization laser system. METHODS:Regional wall motion in 10 patients undergoing catheter-based direct myocardial revascularization using a holmium:yttrium aluminium garnet laser was asses...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Shiran A,Goldstein SA,Ellahham S,Leon MB,Kornowski R

    更新日期:2000-06-01 00:00:00