Fetuin-A is associated with calcified coronary artery disease.

Abstract:

OBJECTIVE:Fetuin-A is a circulating glycoprotein that is involved in various stages of atherosclerosis. Despite the fact that emerging evidence suggests fetuin-A acts as a calcification inhibitor that protects against advanced calcified atherosclerosis in dialyzed patients, the role of fetuin-A in cardiovascular disease is still controversial. As diabetes and uremia make the role of fetuin-A in cardiovascular disease uncertain, we investigated the association between fetuin-A and calcified coronary artery disease in participants without diabetes and renal dysfunction. METHODS:Serum fetuin-A levels were measured in 92 participants who underwent coronary angiography. The number of diseased vessels and the presence of calcification were evaluated. RESULTS:Fetuin-A levels significantly decreased in patients with advanced three-vessel disease compared with those without stenosis (245.5+/-50.9, 289.0+/-71.8 microg/ml, respectively; P<0.05). Likewise, fetuin-A levels were significantly lower in patients with coronary artery calcification compared with those without coronary artery calcification (257.1+/-49.7, 288.0+/-63.1 microg/ml, respectively; P = 0.010). Multivariate logistic regression analysis revealed that fetuin-A levels inversely correlated with the presence of coronary artery calcification (odds ratio: 0.54; 95% confidence interval: 0.31-0.92; P = 0.025). CONCLUSION:Serum fetuin-A levels inversely correlated with advanced calcified coronary artery disease.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Mori K,Ikari Y,Jono S,Emoto M,Shioi A,Koyama H,Shoji T,Ishimura E,Inaba M,Hara K,Nishizawa Y

doi

10.1097/MCA.0b013e32832fe5d5

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

281-5

issue

5

eissn

0954-6928

issn

1473-5830

journal_volume

21

pub_type

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