Effects of an angiotensin-converting enzyme inhibitor (ramipril) on inflammatory markers in secondary prevention patients: RAICES Study.

Abstract:

AIMS:To evaluate the hypothesis that angiotensin-converting enzyme inhibitor therapy with ramipril reduces baseline levels of C-reactive protein in patients at high cardiovascular risk. METHODS:Secondary prevention patients were screened for eligibility and treated with ramipril for 6 month. Baseline and 6-month highly sensitive C-reactive protein levels were determined. RESULTS:A total of 77 patients were analyzed. The median highly sensitive C-reactive protein concentration at baseline was 2.17 mg/l (interquartile interval 0.97-4.54); whereas in post-treatment, the median was 1.70 mg/l (interquartile interval 0.88-3.41), P=0.0009. Patients were stratified according to risk level determined by baseline highly sensitive C-reactive protein levels: low-risk (<1 mg/l), intermediate risk (1-3 mg/l) and high risk (>3 mg/l) The reduction in highly sensitive C-reactive protein occurred at the expense of the high-risk group (baseline 5.02 mg/l, post-treatment 3.3 mg/l, P<0.0001), with no differences in the other groups. In multiple regression analysis, the reduction observed in the high-risk group could not be explained by baseline treatment or change in any of the variables analyzed. CONCLUSION:Highly sensitive C-reactive protein levels were reduced after a 6-month ramipril therapy in secondary prevention patients, suggesting an anti-inflammatory effect of angiotensin-converting enzyme inhibitors. Future investigations will be done to confirm these results, and to investigate how angiotensin-converting enzyme inhibitor treatment elicits anti-inflammatory effects.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Lopez Santi RG,Valeff EC,Duymovich CR,Mazziotta D,Mijailovsky NE,Filippa GC,Maltez R,Hernandez VA,Monroy AG,Borzi JG,Acheme RA,Etchegoyen MC,PROCORDIS investigators.

doi

10.1097/00019501-200510000-00002

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

423-9

issue

7

eissn

0954-6928

issn

1473-5830

pii

00019501-200510000-00002

journal_volume

16

pub_type

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