Comparative effectiveness of different contemporary drug-eluting stents in routine clinical practice: a multigroup propensity score analysis using data from the stent-specific, multicenter, prospective registries.


OBJECTIVE:Data on the comparative effectiveness of contemporary drug-eluting stents (DES) in the unrestricted, real-world setting are limited. We investigated the long-term effectiveness and safety of contemporary different drug-eluting stents by means of multiple treatment propensity score weighting. PATIENTS AND METHODS:From seven stent-specific, prospective DES registries conducted between July 2007 and July 2015, we evaluated 17 196 patients who received several contemporary DES and first-generation DES: 3053 treated with cobalt-chromium everolimus-eluting stents (CoCr-EES), 2985 with platinum-chromium EES (PtCr-EES), 2922 with Resolute zotarolimus-eluting stents (Re-ZES), 789 with Biomatrix biolimus-eluting stents (Bi-BES), 1907 with Nobori biolimus-eluting stents (No-BES), 1970 with Xience Prime cobalt-chromium everolimus-eluting stents (Pr-CoCr-EES), and 3570 with sirolimus-eluting stents (SES). The primary outcome was target-vessel failure (a composite of cardiac death, target-vessel myocardial infarction, or target-vessel revascularization) at 3 years of follow-up and major cardiovascular adverse events (a composite of all-cause death, any myocardial infarction, or any revascularization) was also evaluated. RESULTS:The observed 3-year rates of target-vessel failure were not significantly different among different second-generation DES and SES (CoCr-EES 9.8%, PtCr-EES 9.5%, Re-ZES 9.3%, Bi-BES 9.8%, No-BES 7.7%, Pr-CoCr-EES 10.4%, SES 10.2%; overall P=0.07). In multiple treatment propensity score analysis, adjusted hazard ratios for target-vessel failure were similar in between-group comparisons of several contemporary DES. In addition, no significant differences were observed with respect of the adjusted risk of major adverse cardiac events. CONCLUSION:In this comparative effectiveness research using stent-specific, clinical practice registries involving unrestricted use of several contemporary DES, there were no significant between-group differences in the 3-year rates of target-vessel failure.


Coron Artery Dis


Coronary artery disease


Kwon O,Kang SH,Lee JB,Ahn JM,Lee CH,Kang DY,Lee PH,Kang SJ,Lee SW,Kim YH,Lee CW,Park SW,Park DW,Park SJ,IRIS-DES Registry Investigators.




Has Abstract


2019-06-01 00:00:00












  • Antibodies to oxidized low-density lipoprotein in patients following coronary artery revascularization.

    abstract:BACKGROUND:Measurement of antibodies to oxidized low-density lipoprotein (AB-oxLDL) has been proposed as a way of identifying individuals at risk for cardiovascular disease beyond the determination of LDL cholesterol (LDL-c) alone. While this hypothesis is appealing, evidence that AB-oxLDL is a risk factor independent ...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Miller ER 3rd,Erlinger TP,Blumenthal RS,Margolis S,Allen JK

    更新日期:2003-04-01 00:00:00

  • Long-term events after physician-referred initial tests by myocardial perfusion imaging or computed tomography coronary angiography in patients with suspected coronary artery disease.

    abstract:BACKGROUND:The effects of initial tests on long-term events have been unknown. PATIENTS AND METHODS:In this observational retrospective study, we analyzed the effects of initial noninvasive tests by myocardial perfusion imaging (MPI) and computed tomography angiography (CTA) on long-term major adverse cardiac events (...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Naya M,Uemura Y,Matsumoto N,Momose M,Kato T,Hida S,Yamauchi T,Nakajima T,Suzuki E,Tamaki N,J-COMPASS Extended Follow-Up Study Group.

    更新日期:2018-11-01 00:00:00

  • Early versus delayed coronary artery bypass graft surgery for patients with non-ST elevation myocardial infarction.

    abstract:BACKGROUND:Although coronary artery bypass graft surgery (CABG) has been proven to have mortality and morbidity benefits in patients with non-ST elevation myocardial infarction and multivessel disease, the appropriate timing of this procedure remains unclear. Therefore, we proposed a propensity score-matched analysis c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ha LD,Ogunbayo G,Elbadawi A,Olorunfemi O,Messerli A

    更新日期:2017-12-01 00:00:00

  • Primary percutaneous coronary intervention in ST-elevation myocardial infarction with an ectatic infarct-related artery.

    abstract:OBJECTIVE:The aim of this study was to describe the procedural characteristics, myocardial perfusion, and long-term outcomes in ST-elevation myocardial infarction patients with an ectatic infarct-related artery (IRA). PATIENTS AND METHODS:The retrospective analysis included 1270 consecutive ST-elevation myocardial inf...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Popovic B,Agrinier N,Metzdorf PA,Camenzind E

    更新日期:2019-06-01 00:00:00

  • Coronary revascularization in patients with type 2 diabetes and results of the BARI 2D trial.

    abstract:OBJECTIVES:This Perspective reviews the results of early and contemporary studies evaluating the safety and efficacy of coronary revascularization in patients with diabetes. It also addresses the implications of some of the data in the Bypass Angioplasty Revascularization Investigation in type 2 diabetes (BARI 2D) tria...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Sobel BE

    更新日期:2010-05-01 00:00:00

  • Thyroid hormone and thyroid hormone analogues in the treatment of heart failure.

    abstract::The thyroid hormone analogue DITPA is a promising potential new treatment for heart failure. Although the mechanism of action is incompletely determined, it is clear that DITPA improves systolic as well as diastolic function. It is also clear that the effects of DITPA are intrinsic to the muscle and not the result of ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Spooner PH,Morkin E,Goldman S

    更新日期:1999-09-01 00:00:00

  • Vitamin K1 intake and coronary calcification.

    abstract:OBJECTIVES:The activity of matrix Gla-protein (MGP), a potent inhibitor of vascular calcification, is dependent on carboxylation using vitamin K as a co-factor. In animals, low intake of total vitamin K has been shown to accelerate vascular calcification via the MGP mechanism. This has led to the hypothesis that low le...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Villines TC,Hatzigeorgiou C,Feuerstein IM,O'Malley PG,Taylor AJ

    更新日期:2005-05-01 00:00:00

  • Culprit versus multivessel coronary intervention in ST-segment elevation myocardial infarction: a meta-analysis of randomized trials.

    abstract:BACKGROUND:The 2015 American College of Cardiology/American Heart Association update on primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) recommended PCI of the non-infarct-related artery at the time of primary PCI (class IIb recommendation). Despite ev...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,meta分析


    authors: Vaidya SR,Qamar A,Arora S,Devarapally SR,Kondur A,Kaul P

    更新日期:2018-03-01 00:00:00

  • Biomarker profiles as descriptors of left ventricular remodeling after acute myocardial infarction.

    abstract:BACKGROUND:Biomarker expression can predict subsequent cardiovascular events. The goal of this study was to determine the pattern of expression in blood of a broad array of cytokines and growth factors taken 24-72 h after an ST elevation myocardial infarction (STEMI) involving the left anterior descending (LAD) coronar...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Lam PH,Anderson PR 3rd,Ahmed B,Sobel BE,Vanburen P,Schneider DJ

    更新日期:2011-08-01 00:00:00

  • Thrombocytopenia: a risk factor for acute myocardial infarction during the acute phase of Kawasaki disease.

    abstract:BACKGROUND:We report on 10 patients with Kawasaki disease and thrombocytopenia who were found to have a high incidence of coronary artery aneurysm and acute myocardial infarction. The clinical features of these patients, the cause of their thrombocytopenia and the relationship between cardiovascular pathology and throm...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Niwa K,Aotsuka H,Hamada H,Uchishiba M,Terai M,Niimi H

    更新日期:1995-11-01 00:00:00

  • Rotational atherectomy through the radial artery is associated with similar procedural success when compared with the transfemoral route.

    abstract:OBJECTIVES:Rotational atherectomy (RA) has traditionally been carried out using 7 or 8 Fr guides through a transfemoral approach to allow for passage of 2.0 mm burrs or larger. With transradial percutaneous coronary intervention becoming more common, our aim was to investigate whether transradial RA would offer equival...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Kotowycz MA,Khan SQ,Freixa X,Ivanov J,Seidelin PH,Overgaard CB,Džavík V

    更新日期:2015-05-01 00:00:00

  • Long-term coronary artery graft patency as evaluated by 64-slice coronary computed tomographic angiography.

    abstract:OBJECTIVE:Coronary artery bypass graft (CABG) surgery has been a mainstream surgical procedure for coronary artery disease for the past three decades. 64-Slice coronary computed tomographic angiography (CCTA) has been established as an accurate alternative to invasive coronary artery angiography for postoperative evalu...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Levisman JM,Budoff MJ,Karlsberg RP

    更新日期:2011-12-01 00:00:00

  • Insights into coronary collateral formation from a novel porcine semiacute infarction model.

    abstract:BACKGROUND:For patients with severe ischemic heart disease, complete revascularization by a percutaneous coronary intervention or coronary artery bypass grafting is often not achieved and may still cause residual angina. In case of progressive coronary artery occlusions, therapeutic arteriogenesis constitutes a promisi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Krackhardt F,Harnoss JM,Waliszewski MW,Ritter Z,Granzow S,Felsenberg D,Neumann K,Lerman LO,Hillmeister P,Gebker R,Paetsch I,Riediger F,Bramlage P,Buschmann IR

    更新日期:2018-03-01 00:00:00

  • Comparison of 2-year outcomes of repeated second-generation drug-eluting stent implantation for focal-type versus nonfocal-type in-stent restenosis.

    abstract:BACKGROUND:Second-generation drug-eluting stents (DES) have been used widely to treat DES in-stent restenosis (ISR), which remains a clinical challenge. Knowledge of the outcomes of repeated second-generation DES implantation for focal versus nonfocal-type ISR is still missing. METHODS:In the current study, 254 patien...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Zhu W,Li J,Luo H,Wang G,Hua Q

    更新日期:2015-11-01 00:00:00

  • New carotid plaque, but not the progression of intima-media thickness, predicts the progression of high-risk coronary plaque.

    abstract:BACKGROUND:Carotid intima-media thickness (CIMT) is regarded as a controversial risk marker for cardiovascular disease (CVD). We aimed to evaluate the role of CIMT and carotid plaque progression as predictors for the progression of coronary plaque and compositions. METHODS:In the Garlic 4 study, asymptomatic patients ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Chao CJ,Lakshmanan S,Ceponiene I,Luo Y,Nakanishi R,Nezarat N,Kanisawa M,Budoff MJ

    更新日期:2021-01-06 00:00:00

  • Long-term effectiveness and safety of triple versus dual antiplatelet therapy after percutaneous coronary intervention for unprotected left main coronary artery disease.

    abstract:OBJECTIVES:We sought to compare the long-term effectiveness and safety of triple antiplatelet therapy (TAPT) versus dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) for unprotected left main coronary artery disease (uLMCAD). BACKGROUND:An additional strategy to reduce recurrent ischemia ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Lee HJ,Yu CW,Hwang HK,Choi RK,Park JS,Li H,Ro YM

    更新日期:2013-11-01 00:00:00

  • Prognostic impact of lipoprotein(a) levels during lipid management with statins after ST-elevation acute myocardial infarction.

    abstract::The causal relationship of lipoprotein(a) with cardiovascular disease has been established. However, clinical impacts of lipoprotein(a) levels on adverse vascular events in patients with established coronary artery disease who are undergoing statin treatment have not been fully elucidated. We measured lipoprotein(a) l...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Mitsuda T,Uemura Y,Ishii H,Tanaka A,Takemoto K,Koyasu M,Ishikawa S,Shibata R,Watarai M,Murohara T

    更新日期:2019-12-01 00:00:00

  • Low-pressure deployment of stents: short- and long-term outcome.

    abstract::This study investigates a strategy of low-pressure stenting with concomitant anti-platelet treatment designed to prevent short- and long-term events after stenting. Ninety consecutive patients who underwent percutaneous transluminal coronary angioplasty with stenting using low-pressure stent deployment (mean 8.1 atmos...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Cafri C,Weinstein JM,Gilutz H,Kobal S,Ilia R

    更新日期:2001-06-01 00:00:00

  • Thrombomodulin -33G/A and Ala455Val polymorphisms are associated with the risk of coronary artery disease: a meta-analysis including 12 584 patients.

    abstract:BACKGROUND:Thrombomodulin (TM) -33G/A and Ala455Val polymorphisms have been indicated to be correlated with the risk of coronary artery disease (CAD), but study results are still inclusive. Thus, a meta-analysis was carried out. MATERIALS AND METHODS:Databases including PubMed, Embase, CNKI, and Web of Science (ISI) w...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,meta分析,评审


    authors: Wang H,Dong P

    更新日期:2015-01-01 00:00:00

  • Clinical and angiographical characteristics of acetylcholine- induced spasm: relationship to dose of intracoronary injection of acetylcholine.

    abstract:OBJECTIVES:The purpose of this study was to clarify clinical and angiographical characteristics of acetylcholine (ACh)-induced spasm in the right and left coronary artery. METHODS AND RESULTS:We performed 557 consecutive procedures of spasm provocation tests of ACh from January 1991 to December 2000 in patients withou...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Sueda S,Kohno H,Fukuda H,Inoue K,Suzuki J,Watanabe K,Ochi T,Uraoka T

    更新日期:2002-06-01 00:00:00

  • Early repolarization in the inferolateral leads predicts the presence of vasospastic angina: a novel predictor in patients with resting angina.

    abstract:BACKGROUND:An association between early repolarization and ventricular fibrillation has recently been reported in patients with vasospastic angina (VSA). However, no studies have clarified whether the presence of early repolarization can predict VSA. METHODS:Participants comprised 286 patients (136 males) with clinica...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ikeda H,Hasegawa K,Uzui H,Fukuoka Y,Shiomi Y,Tama N,Miyazaki S,Ishida K,Tada H

    更新日期:2020-11-13 00:00:00

  • Prediction of cardiovascular mortality in patients with ST-elevation myocardial infarction after primary percutaneous coronary intervention.

    abstract:OBJECTIVES:We analyzed a large patient group to develop a clinical risk score that could be applied to patients after primary percutaneous coronary intervention (PCI). METHODS:We reviewed 2529 consecutive patients treated with primary PCI for ST-elevation myocardial infarction between 2003 and 2008. All clinical, angi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ergelen M,Gorgulu S,Uyarel H,Norgaz T,Ayhan E,Akkaya E,Soylu O,Ugur M,Tezel T

    更新日期:2010-06-01 00:00:00

  • Is reoperative coronary artery bypass grafting in patients with poor left ventricular ejection fractions < or = 25% worthwhile?

    abstract:AIM:This study aimed to investigate whether patients with very low left ventricular ejection fractions (LVEF) should be accepted for reoperative coronary artery bypass grafting (CABG). STUDY POPULATION:Between January 1990 and December 1993, 1681 patients underwent primary CABG and 308 (15.5%) reoperative CABG. One hu...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Christenson JT,Bloch A,Maurice J,Simonet F,Velebit V,Schmuziger M

    更新日期:1995-05-01 00:00:00

  • Association between serum galectin-3 levels and coronary atherosclerosis and plaque burden/structure in patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:Levels of galectin-3, a member of a family of soluble β-galactoside-binding lectins, are reported to be higher in patients with type 2 diabetes mellitus (DM) and metabolic syndrome. Conflicting results exist on the effects of galectin-3 in diabetic patients. The aim of this study was to investigate the relat...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ozturk D,Celik O,Satilmis S,Aslan S,Erturk M,Cakmak HA,Kalkan AK,Ozyilmaz S,Diker V,Gul M

    更新日期:2015-08-01 00:00:00

  • Predictive value of coronary artery dilation response to nitrate for a positive intracoronary acetylcholine provocation test.

    abstract:BACKGROUND:Baseline coronary artery diameter and coronary artery dilation response to nitrate are associated with coronary vasoreactivity. OBJECTIVES:The present study investigated the predictive value of coronary artery tone for a positive intracoronary acetylcholine (ACh) provocation test. METHODS:A total of 197 pa...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Saito Y,Kitahara H,Shoji T,Tokimasa S,Nakayama T,Sugimoto K,Fujimoto Y,Kobayashi Y

    更新日期:2016-11-01 00:00:00

  • Long-term clinical impact of polymer-free sirolimus-eluting stents in unselected patients.

    abstract:OBJECTIVES:The long-term clinical impact of polymer-free sirolimus-eluting stents (PF-SES) in unselected patients undergoing percutaneous coronary intervention (PCI) still remains poorly investigated. We studied the long-term clinical impact of PF-SES in a large cohort of unselected patients receiving PCI therapy at tw...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Sinha N,Rai H,Cassese S,Kumar S,Kapoor A,Kastrati A

    更新日期:2016-08-01 00:00:00

  • Hospitalisations, infarct development, and mortality in patients with chest pain and a normal admission electrocardiogram in relation to gender.

    abstract:BACKGROUND:The aim of this study was to compare the outcome for men and women with chest pain or other symptoms suggestive of acute myocardial infarction (AMI) and a normal ECG on admission. METHODS:All patients who presented to our emergency room over a 21-month period with chest pain or other symptoms suggestive of ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Karlson BW,Herlitz J

    更新日期:1996-03-01 00:00:00

  • Reduced low-frequency heart rate variability relates to greater intimal-medial thickness of the carotid wall in two samples.

    abstract:INTRODUCTION:We investigated the relationship between heart rate variability and preclinical carotid intima-media thickening, a putative index of atherosclerosis. METHODS:A sample of 350 men and women (mean age 56.8 years) selected for the presence or absence of untreated hypertension was assessed for heart rate varia...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Gautier C,Stine L,Jennings JR,Sutton-Tyrrell K,Muldoon MB,Kamarck TW,Kaplan GA,Salonen J,Manuck SB

    更新日期:2007-03-01 00:00:00

  • Diagnostic accuracy of optical coherence tomography and intravascular ultrasound for the detection and characterization of atherosclerotic plaque composition in ex-vivo coronary specimens: a comparison with histology.

    abstract:BACKGROUND:Both intravascular ultrasound and optical coherence tomography have been purported to accurately detect and characterize coronary atherosclerotic plaque composition. The aim of our study was to directly compare the reproducibility and diagnostic accuracy of optical coherence tomography and intravascular ultr...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Rieber J,Meissner O,Babaryka G,Reim S,Oswald M,Koenig A,Schiele TM,Shapiro M,Theisen K,Reiser MF,Klauss V,Hoffmann U

    更新日期:2006-08-01 00:00:00

  • Effect of niceritrol on fibrinolysis and lipoprotein (a) levels in patients with coronary artery disease.

    abstract:BACKGROUND:Lipoprotein (a) [Lp(a)] is an independent risk factor for coronary artery disease and niceritrol (a prodrug of nicotinic acid) is known to reduce Lp(a) levels. Patients with coronary artery disease often have impairment of the fibrinolytic system. METHODS:To elucidate the effect of niceritrol on fibrinolysi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Suefuji H,Ogawa H,Yasue H,Imoto N,Sakamoto T,Miyao Y,Kaikita K,Soejima H,Nishiyama K

    更新日期:1996-02-01 00:00:00