Abstract:
BACKGROUND:Free-radical generation after successful thrombolysis in acute myocardial infarction may jeopardize ischaemic but viable myocardium, thus limiting the optimal benefits of reperfusion. METHODS:Circulating free-radical activity was assessed in 25 consecutive patients with acute myocardial infarction. Those who successfully reperfused (Group A) were compared with those who did not (Group B). We also compared patients who had or had not developed Q waves and patients with and without previous angina or myocardial infarction. All patients presented within 6 h of the onset of chest pain and received standard intravenous streptokinase therapy. Free-radical activity in serial serum samples collected over 72 h was measured using the percentage molar ratio (PMR) of the concentrations of 9,11-linoleic acid to 9,12-linoleic acid, and malonaldehyde concentration. RESULTS:Throughout the study period Group A (n = 11) showed significantly greater change in serum PMR and malonaldehyde levels compared with Group B (n = 14) (P < 0.01). PMR differences between the two groups were most pronounced at 3 and 12 h (P < 0.001). Patients with non-Q-wave myocardial infarction (n = 5) showed significantly greater changes in serum PMR and malonaldehyde levels (P < 0.01) compared with those with Q-wave infarction (n = 20). A history of previous infarction or angina had no apparent effects on the changes in serum free-radical activity. CONCLUSIONS:Successful early reperfusion and non-Q-wave myocardial infarction are both associated with a significantly greater increase in the levels of markers of serum free-radical activity immediately after infarction. The results support present concepts of free-radical-mediated reperfusion injury. Use of these assays may identify those patients who may be at risk from free-radical-mediated reperfusion injury.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Grech ED,Jack CI,Bleasdale C,Jackson MJ,Baines M,Faragher EB,Hind CR,Perry RAdoi
10.1097/00019501-199309000-00003subject
Has Abstractpub_date
1993-09-01 00:00:00pages
769-74issue
9eissn
0954-6928issn
1473-5830journal_volume
4pub_type
杂志文章abstract:OBJECTIVE:This study aimed at evaluating efficacy and safety of thrombus aspiration and intracoronary-targeted thrombolysis on coronary thrombus burden in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous catheterization, comparing their effects on myocardial perfusion through index of...
journal_title:Coronary artery disease
pub_type: 杂志文章,随机对照试验
doi:10.1097/MCA.0000000000000743
更新日期:2019-12-01 00:00:00
abstract::Detection of viable myocardium in patients with left ventricular dysfunction has become an increasingly important guide to prognosis and treatment. This article reviews the current status and future potential for the application of modalities to assess myocardial viability. Imaging and other techniques that are review...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/00019501-200609000-00011
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:Red cell distribution width (RDW), a measure of red blood cell size heterogeneity, was evaluated in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Higher RDW is associated with mortality in patients with symptomatic car...
journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
abstract:AIMS:Uric acid (UA) has been associated with the presence and severity of coronary artery disease. To further assess the role of UA role in coronary artery disease, we investigated UA levels in both healthy asymptomatic middle-aged individuals and in different subgroups of hospitalized patients with suspected or defini...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000593
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Adenosine plays a key role in different protective and adaptive responses to ischemia and has been suggested to induce ischemic preconditioning. AIM:To investigate whether a low-dose adenosine infusion reduces the ischemic burden induced by pharmacological stress without affecting the coronary flow reserve ...
journal_title:Coronary artery disease
pub_type: 杂志文章,随机对照试验
doi:10.1097/mca.0b013e32832ac5c1
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:The role of thrombolytic therapy (TT) and percutaneous coronary interventions (PCIs) in subgroups of patients with right ventricular infarction (RVI) has not been evaluated. METHODS AND RESULTS:We risk-stratified 302 patients with RVI into three subsets upon admission. Class A (n=197) comprised patients wit...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200202000-00008
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:We characterized the impact of the metabolic syndrome (MetS) and its components on cardiovascular adverse events in patients with symptomatic chronic multivessel coronary artery disease, which have been followed prospectively for 2 years. METHODS:Patients enrolled in the MASS II study were evaluated for each...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/MCA.0b013e328306aa8a
更新日期:2008-09-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0b013e32833aa6d1
更新日期:2010-08-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200302000-00010
更新日期:2003-02-01 00:00:00
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更新日期:2012-05-01 00:00:00
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journal_title:Coronary artery disease
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doi:10.1097/MCA.0000000000000189
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journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0b013e32835b3932
更新日期:2013-01-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000696
更新日期:2019-03-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000569
更新日期:2018-03-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200002000-00013
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Platelets have an important role in coronary thrombosis. METHODS:We studied 151 consecutive patients undergoing implantation of Palmaz-Schatz stents because of suboptimal results after coronary balloon angioplasty treated by intense anticoagulation. Surface exposure of the constitutively expressed glycoprot...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199703000-00001
更新日期:1997-03-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章,评审
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200502000-00009
更新日期:2005-02-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/01.mca.0000076511.29238.f1
更新日期:2003-06-01 00:00:00
abstract:AIM:The aim of this meta-analysis was to evaluate the efficacy of drug-eluting balloons (DEBs) plus bare-metal stents (BMS) for the treatment of de-novo coronary lesions. METHODS AND RESULTS:Eleven trials involving 1279 patients were included in this study. The main endpoints were as follows: late lumen loss (LLL), bi...
journal_title:Coronary artery disease
pub_type: 杂志文章,meta分析
doi:10.1097/MCA.0000000000000372
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Thrombomodulin (TM) -33G/A and Ala455Val polymorphisms have been indicated to be correlated with the risk of coronary artery disease (CAD), but study results are still inclusive. Thus, a meta-analysis was carried out. MATERIALS AND METHODS:Databases including PubMed, Embase, CNKI, and Web of Science (ISI) w...
journal_title:Coronary artery disease
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MCA.0000000000000161
更新日期:2015-01-01 00:00:00
abstract:AIM:This study aimed to investigate whether patients with very low left ventricular ejection fractions (LVEF) should be accepted for reoperative coronary artery bypass grafting (CABG). STUDY POPULATION:Between January 1990 and December 1993, 1681 patients underwent primary CABG and 308 (15.5%) reoperative CABG. One hu...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199505000-00010
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:The effects of initial tests on long-term events have been unknown. PATIENTS AND METHODS:In this observational retrospective study, we analyzed the effects of initial noninvasive tests by myocardial perfusion imaging (MPI) and computed tomography angiography (CTA) on long-term major adverse cardiac events (...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0000000000000645
更新日期:2018-11-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3283452431
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:The aim of the present study is to investigate incidence, predictors, and long-term outcomes of suboptimal coronary flow after primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) in a large population. METHODS:A total of 2056 consecutive patients with STEMI (mean ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32834f1b8a
更新日期:2012-03-01 00:00:00
abstract:AIMS:Compare the degree of acute vascular injury caused by a polymer-free, thin-strut drug-eluting stent (DES) to that caused by a bioresorbable polymer, thick-strut DES using optical coherence tomography (OCT). METHODS AND RESULTS:Fifty patients requiring nonurgent PCI were randomized to receive either a thin or a th...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000943
更新日期:2020-08-19 00:00:00