Impact of metabolic syndrome on the outcome of patients with stable coronary artery disease: 2-year follow-up of the MASS II study.


OBJECTIVE:We characterized the impact of the metabolic syndrome (MetS) and its components on cardiovascular adverse events in patients with symptomatic chronic multivessel coronary artery disease, which have been followed prospectively for 2 years. METHODS:Patients enrolled in the MASS II study were evaluated for each component of the MetS, as well as the full syndrome. RESULTS:The criteria for MetS were fulfilled in 52% of patients. The presence of MetS (P<0.05), glucose intolerance (P=0.007), and diabetes (P=0.04) was associated with an increased mortality in our studied population. Moreover, despite a clear tendency for each of its components to increase the mortality risk, only the presence of the MetS significantly increased the risk of mortality among nondiabetic study participants in a multivariate model (P=0.03, relative risk 3.5, 95% confidence interval 1.1-6). Finally, MetS was still associated with increased mortality even after adjustment for diabetes status. These results indicate a strong and consistent relationship of the MetS with mortality in patients with stable coronary artery disease. CONCLUSION:Although glucose homeostasis seems to be the major force driving the increased risk of MetS, the operational diagnosis of MetS still has information for stratifying patients when diabetes information is taken into account.


Coron Artery Dis


Coronary artery disease


Lopes NH,Paulitsch FS,Pereira AC,Góis AF,Gagliardi A,Garzillo CL,Ferreira JF,Stolf NA,Hueb W




Has Abstract


2008-09-01 00:00:00














  • Prediction of postpercutaneous coronary intervention myocardial infarction: insights from intravascular imaging, coronary flow, and biomarker evaluation.

    abstract:BACKGROUND:Percutaneous coronary intervention-induced myocardial infarction (PMI) has prognostic significance. Identifying patients at high risk for PMI is desirable as it may alter strategy and facilitate early preventative therapy. We therefore sought to establish whether preprocedural demographic, interventional (pl...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Hoole SP,Hernández-Sánchez J,Brown AJ,Giblett JP,Bennett MR,West NEJ

    更新日期:2018-05-01 00:00:00

  • Multidetector computed tomography guidance in complex cardiac ablations.

    abstract::Radiofrequency ablation of complex cardiac arrhythmias has undergone significant evolution in the past decade, with the development of technology enabling better anatomic and electrophysiologic mapping of abnormal cardiac tissue. In this paper, we will discuss the role of pre-procedural and post-procedural multidetect...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Lobel RM,Lustgarten DL,Spector PS

    更新日期:2006-03-01 00:00:00

  • Diurnal variation of the P-wave dispersion in chronic ischemic heart diseases.

    abstract:OBJECTIVE:Electrocardiographic indices like maximum P-wave duration (P(max)) and P-wave dispersion (PD) can be used to detect patients with atrial conduction disorders, myocardial ischemia and those at risk for atrial fibrillation. Considering the diurnal variation of ischemia in patients with significant coronary lesi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yíldírím N,Topaloglu S,Bozboga S,Ocal A,Saricam E

    更新日期:2006-12-01 00:00:00

  • Incidence, treatment, and in-hospital outcome of bifurcation lesions in patients undergoing percutaneous coronary interventions for chronic total occlusions.

    abstract:BACKGROUND:Bifurcation lesions represent a distinct lesion subset associated with an increased risk of procedural complications. Data on the incidence, treatment, and outcome of bifurcation lesions associated with chronic total occlusions are limited. METHODS:Among chronic total occlusion procedures performed by a sin...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Galassi AR,Boukhris M,Tomasello SD,Marzà F,Azzarelli S,Giubilato S,Khamis H

    更新日期:2015-03-01 00:00:00

  • Early repolarization in the inferolateral leads predicts the presence of vasospastic angina: a novel predictor in patients with resting angina.

    abstract:BACKGROUND:An association between early repolarization and ventricular fibrillation has recently been reported in patients with vasospastic angina (VSA). However, no studies have clarified whether the presence of early repolarization can predict VSA. METHODS:Participants comprised 286 patients (136 males) with clinica...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ikeda H,Hasegawa K,Uzui H,Fukuoka Y,Shiomi Y,Tama N,Miyazaki S,Ishida K,Tada H

    更新日期:2020-11-13 00:00:00

  • The phytoestrogens Genistein and Daidzein, and 17 beta-estradiol inhibit development of neointima in aortas from male and female rabbits in vitro after injury.

    abstract:BACKGROUND:17 beta-Estradiol and phytoestrogens are known to have beneficial effects on the cardiovascular systems of women. The exact mechanisms for how estrogens and phytoestrogens influence the cardiovascular system are not yet understood in detail. OBJECTIVE:The objective of this study was to investigate whether 1...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Finking G,Wohlfrom M,Lenz C,Wolkenhauer M,Eberle C,Hanke H

    更新日期:1999-12-01 00:00:00

  • Widowhood and severity of coronary artery disease: a multicenter study.

    abstract:OBJECTIVES:The aim of this study was to assess the association of widowhood with the severity and extent of coronary artery disease (CAD), and whether it is modified by sex or socioeconomic status. PATIENTS AND METHODS:A total of 1068 patients undergoing coronary angiography at five centers in Saudi Arabia and the Uni...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Daoulah A,Alama MN,Elkhateeb OE,Al-Murayeh M,Al-Kaabi S,Al-Faifi SM,Alosaimi HM,Lotfi A,Asiri KS,Elimam AM,Abougalambo AS,Murad W,Haddara MM,Dixon CM,Alsheikh-Ali AA

    更新日期:2017-03-01 00:00:00

  • The risk of stroke in patients with acute myocardial infarction treated invasively.

    abstract:BACKGROUND:To assess the incidence, clinical significance, and independent risk factors of stroke in patients with acute myocardial infarction (AMI) treated invasively. MATERIALS AND METHODS:We analyzed 2520 consecutive patients with AMI admitted between 2003 and 2007. Data on long-term follow-up were screened to iden...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Podolecki TS,Lenarczyk RK,Kowalczyk JP,Mazurek MH,Swiątkowski AM,Chodór PK,Pruszkowska-Skrzep PI,Sędkowska AA,Poloński L,Kalarus ZF

    更新日期:2012-01-01 00:00:00

  • Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry.

    abstract:BACKGROUND:Adiponectin and resistin, which have counteracting effects, are suggested to be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear. The aim of this study was to evaluate the prognostic values of these adipokin...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Lee SH,Ha JW,Kim JS,Choi EY,Park S,Kang SM,Choi D,Jang Y,Chung N

    更新日期:2009-01-01 00:00:00

  • Incidence, predictors, and 30-day outcomes of new-onset atrial fibrillation after primary percutaneous coronary intervention: insight into the RISK-PCI trial.

    abstract:OBJECTIVES:Limited data exist about the prognostic significance of new-onset atrial fibrillation (AF) after contemporary primary percutaneous coronary intervention (pPCI). The objective of this study was to identify the incidence and predictors of new-onset AF and associated adverse 30-day outcomes in AF patients who u...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章


    authors: Mrdovic I,Savic L,Krljanac G,Perunicic J,Asanin M,Lasica R,Antonijevic N,Kocev N,Marinkovic J,Vasiljevic Z,Ostojic M

    更新日期:2012-01-01 00:00:00

  • Comparison of peripheral arterial tonometry and flow-mediated vasodilation for assessment of the severity and complexity of coronary artery disease.

    abstract:OBJECTIVE:Noninvasive flow-mediated vasodilation (FMD) is a widely used method to assess endothelial function, but its technical difficulty and problems remain obstacles for use in clinical practice. Reactive hyperemia-peripheral arterial tonometry (RH-PAT) was developed as a simpler and more reproducible method. We co...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Woo JS,Jang WS,Kim HS,Lee JH,Choi EY,Kim JB,Kim WS,Kim KS,Kim W

    更新日期:2014-08-01 00:00:00

  • Drug-coated balloon treatment for nonsmall de-novo coronary artery disease: angiographic and clinical outcomes.

    abstract:OBJECTIVES:Although drug-coated balloons (DCBs) are established for de-novo lesions in small coronary arteries, the impact of DCB treatment according to the reference vessel diameter (RVD) remains poorly defined. This study aimed to evaluate the angiographic and long-term clinical outcomes of DCB treatment for de-novo ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Her AY,Yuan SL,Jun EJ,Bhak Y,Kim MH,Garg S,Kim YH,Kun L,Hui L,Zhi W,Hao J,Zhentao S,Qiang T,Shin ES

    更新日期:2021-01-18 00:00:00

  • Plasma nuclear and mitochondrial DNA levels in acute myocardial infarction patients.

    abstract:OBJECTIVE:Plasma nuclear and mitochondrial DNA (mtDNA) levels are altered in many diseases. However, it is not known whether they are also altered in acute myocardial infarction (AMI). In the present study, we examined plasma nuclear and mtDNA levels in the patients with AMI before and after a percutaneous coronary int...

    journal_title:Coronary artery disease

    pub_type: 社论


    authors: Wang L,Xie L,Zhang Q,Cai X,Tang Y,Wang L,Hang T,Liu J,Gong J

    更新日期:2015-06-01 00:00:00

  • Thrombomodulin -33G/A and Ala455Val polymorphisms are associated with the risk of coronary artery disease: a meta-analysis including 12 584 patients.

    abstract:BACKGROUND:Thrombomodulin (TM) -33G/A and Ala455Val polymorphisms have been indicated to be correlated with the risk of coronary artery disease (CAD), but study results are still inclusive. Thus, a meta-analysis was carried out. MATERIALS AND METHODS:Databases including PubMed, Embase, CNKI, and Web of Science (ISI) w...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,meta分析,评审


    authors: Wang H,Dong P

    更新日期:2015-01-01 00:00:00

  • Plaque composition and morphologic characteristics in significant left main bifurcation disease; virtual histology intravascular ultrasound study.

    abstract:OBJECTIVES:Although the left main coronary artery (LMCA) is clinically the most important site, little is known about the longitudinal plaque distribution and composition in the significant LMCA disease. METHODS:Preprocedure virtual histology intravascular ultrasound data were analyzed in 120 patients with significant...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Chang M,Kang SJ,Yoon SH,Ahn JM,Park DW,Lee SW,Kim YH,Lee CW,Park SW,Nakazawa G,Mintz GS,Park SJ

    更新日期:2016-12-01 00:00:00

  • Long-term events after physician-referred initial tests by myocardial perfusion imaging or computed tomography coronary angiography in patients with suspected coronary artery disease.

    abstract:BACKGROUND:The effects of initial tests on long-term events have been unknown. PATIENTS AND METHODS:In this observational retrospective study, we analyzed the effects of initial noninvasive tests by myocardial perfusion imaging (MPI) and computed tomography angiography (CTA) on long-term major adverse cardiac events (...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Naya M,Uemura Y,Matsumoto N,Momose M,Kato T,Hida S,Yamauchi T,Nakajima T,Suzuki E,Tamaki N,J-COMPASS Extended Follow-Up Study Group.

    更新日期:2018-11-01 00:00:00

  • Systolic hypertension in older patients: are calcium channel antagonists safe?

    abstract::The Editor and Associate Editors are pleased that our readership will have the opportunity to benefit from a series of contributions by Dr John Rutherford addressing current issues in pharmacology and therapeutics pertinent to coronary artery disease. We are pleased also that Dr Rutherford will provide authoritative p...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Rutherford JD

    更新日期:2000-12-01 00:00:00

  • Decreased carotid intima-media thickness in patients with coronary artery ectasia compared with patients with coronary artery disease.

    abstract:BACKGROUND:Although atherosclerosis is supposed to be responsible for more than 50% of coronary artery ectasia, the precise pathology of coronary artery ectasia is not clearly understood. A histopathological examination of ectatic segments has revealed mainly destruction of the media layer of the artery. In the present...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yetkin E,Acikgoz N,Aksoy Y,Bariskaner E,Sivri N,Akturk E,Turhan H,Kosar F,Cehreli S

    更新日期:2005-12-01 00:00:00

  • Interaction of CYP2C19 G681A polymorphism and omeprazole on clopidogrel responsiveness and impact in patients with acute coronary syndrome.

    abstract:OBJECTIVE:The aim of this study was to explore the individual effects of the CYP2C19 G681A polymorphism and omeprazole use and their interaction on clopidogrel responsiveness in acute coronary syndrome (ACS). The CYP2C19 G681A polymorphism and omeprazole use were both known for retarding the effects of clopidogrel unde...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Jirungda S,Pussadhamma B,Komanasin N,Senthong V,Leuangwatthananon W

    更新日期:2020-05-01 00:00:00

  • Increased left ventricular non-uniformity in hypertensive patients with angina.

    abstract:AIM:To determine how hypertension affects the left ventricular diastolic function of patients with effort angina. METHODS:We performed radionuclide ventriculography in 14 patients with isolated stenosis of the left anterior descending coronary artery and in seven healthy volunteers. RESULTS:Neither global nor regiona...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Nii T,Arakawa K

    更新日期:1994-10-01 00:00:00

  • Final 5-year results of the TAXUS ATLAS, TAXUS ATLAS Small Vessel, and TAXUS ATLAS Long Lesion clinical trials of the TAXUS Liberté paclitaxel-eluting stent in de-novo coronary artery lesions.

    abstract:OBJECTIVE:To report the final, cumulative, 5-year outcomes from the TAXUS ATLAS program, which studied the use of the TAXUS Liberté paclitaxel-eluting stent in de-novo coronary artery lesions. METHODS:TAXUS ATLAS Workhorse, Small Vessel, and Long Lesion are nonrandomized studies comparing TAXUS Liberté (N=871), TAXUS ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Ormiston JA,Charles O,Mann T,Hall JJ,McGarry T,Cannon LA,Webster MW,Mishkel GJ,Underwood PL,Dawkins KD

    更新日期:2013-01-01 00:00:00

  • Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: rationale and design.

    abstract:BACKGROUND AND AIM:The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Nakanishi R,Post WS,Osawa K,Jayawardena E,Kim M,Sheidaee N,Nezarat N,Rahmani S,Kim N,Hathiramani N,Susarla S,Palella F,Witt M,Blaha MJ,Brown TT,Kingsley L,Haberlen SA,Dailing C,Budoff MJ

    更新日期:2018-01-01 00:00:00

  • Dual response to Fas ligation in human endothelial cells: apoptosis and induction of chemokines, interleukin-8 and monocyte chemoattractant protein-1.

    abstract:BACKGROUND:To maintain the integrity of tissues, endothelial cells play critical roles. Fas ligand (FasL) is well known to deliver a death signal through its receptor, Fas. The Fas/FasL system may concomitantly induce expressions of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) besides triggering ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yamaoka-Tojo M,Yamaguchi S,Nitobe J,Abe S,Inoue S,Nozaki N,Okuyama M,Sata M,Kubota I,Nakamura H,Tomoike H

    更新日期:2003-02-01 00:00:00

  • Sequelae of spinal cord stimulation for refractory angina pectoris. Reliability and safety profile of long-term clinical application.

    abstract:BACKGROUND:Spinal cord stimulation (SCS) is effective in the treatment of severe coronary artery disease (CAD) unresponsive to anti-anginal medication or revascularization procedures. However, there is still concern about its safety. OBJECTIVE:To investigate the reliability, morbidity, and mortality aspects of SCS in ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Jessurun GA,Ten Vaarwerk IA,DeJongste MJ,Tio RA,Staal MJ

    更新日期:1997-01-01 00:00:00

  • Diagnostic work-up of unselected patients with suspected coronary artery disease: complementary role of multidetector computed tomography, symptoms and electrocardiogram stress test.

    abstract:AIM:We evaluated the accuracy of multidetector computed tomography in detecting coronary artery disease and how it could change the indication to coronary angiography in patients with suspected cardiac chest pain. METHODS AND RESULTS:We enrolled 142 consecutive patients who had already performed an exercise electrocar...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Pontone G,Andreini D,Ballerini G,Nobili E,Pepi M

    更新日期:2007-06-01 00:00:00

  • Comparative effectiveness of different contemporary drug-eluting stents in routine clinical practice: a multigroup propensity score analysis using data from the stent-specific, multicenter, prospective registries.

    abstract:OBJECTIVE:Data on the comparative effectiveness of contemporary drug-eluting stents (DES) in the unrestricted, real-world setting are limited. We investigated the long-term effectiveness and safety of contemporary different drug-eluting stents by means of multiple treatment propensity score weighting. PATIENTS AND MET...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Kwon O,Kang SH,Lee JB,Ahn JM,Lee CH,Kang DY,Lee PH,Kang SJ,Lee SW,Kim YH,Lee CW,Park SW,Park DW,Park SJ,IRIS-DES Registry Investigators.

    更新日期:2019-06-01 00:00:00

  • Coronary artery calcium score: pivotal role as a predictor for detecting coronary artery disease in symptomatic patients.

    abstract::Chest pain and dyspnea are common presentations for symptomatic individuals with suspected coronary artery disease (CAD) in the primary care office and cardiology clinics. However, it is imperative to properly diagnose who should undergo further evaluation for cardiac etiologies of chest pain, with either noninvasive ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Cherukuri L,Birudaraju D,Budoff MJ

    更新日期:2021-01-18 00:00:00

  • Cancer-related deaths among different treatment options in chronic coronary artery disease: results of a 6-year follow-up of the MASS II study.

    abstract:INTRODUCTION:The primary end points of randomized clinical trials evaluating the outcome of therapeutic strategies for coronary artery disease (CAD) have included nonfatal acute myocardial infarction, the need for further revascularization, and overall mortality. Noncardiac causes of death may distort the interpretatio...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,随机对照试验


    authors: Vieira RD,Pereira AC,Lima EG,Garzillo CL,Rezende PC,Favarato D,Hueb AC,Gersh BJ,Ramires JA,Hueb W

    更新日期:2012-03-01 00:00:00

  • The diagnostic and prognostic value of tissue Doppler imaging during dobutamine stress echocardiography in end-stage renal disease.

    abstract:OBJECTIVE:To determine whether a quantitative measurement of peak systolic velocity (PSV) during dobutamine stress echocardiography (DSE) detects severe coronary artery disease (CAD) and predicts mortality in patients with end-stage renal disease. METHODS:One hundred and forty renal transplant candidates had DSE and c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Sharma R,Mehta RL,Brecker SJ,Gaze DC,Gregson H,Streather CP,Collinson PO,Pellerin D

    更新日期:2009-05-01 00:00:00

  • New insights into the pathophysiology, classification, and diagnosis of coronary microvascular dysfunction.

    abstract::The coronary microvasculature plays a key role in determining and modulating coronary blood flow across the spectrum of myocardial demand. Our understanding of this complex system has been limited partly due to our inability to visualize the anatomy of an extensive microvascular bed and its complicated functional path...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Ahmed B

    更新日期:2014-08-01 00:00:00