The association between uric acid levels and different clinical manifestations of coronary artery disease.

Abstract:

AIMS:Uric acid (UA) has been associated with the presence and severity of coronary artery disease. To further assess the role of UA role in coronary artery disease, we investigated UA levels in both healthy asymptomatic middle-aged individuals and in different subgroups of hospitalized patients with suspected or definite myocardial infarction (MI). PATIENTS AND METHODS:The severity of coronary artery calcification (CAC) was examined in asymptomatic individuals (n=1039) using a noncontrast computed tomography scan. Hospitalized patients with suspected acute MI (n=772) were grouped according to troponin I (TnI) concentrations: (i) elevated TnI concentrations (>0.03 µg/l) with subdivision according to the type of MI and other clinical conditions associated with myocardial injury, or (ii) nonelevated TnI concentrations (≤0.03 µg/l). RESULTS:UA was not associated with the severity of CAC in asymptomatic individuals when adjusting for relevant risk factors. Patients with type 2 MI and patients with myocardial injury associated with conditions of myocardial ischemia showed significantly higher UA levels (0.390 mmol/l, P=0.002 and 0.400 mmol/l, P=0.001, respectively) than patients with type 1 MI (0.329 mmol/l), after adjusting for other risk factors. CONCLUSION:UA was not correlated with the severity of CAC in asymptomatic middle-aged individuals, and patients with type 2 MI or ischemic myocardial injury were shown to have higher UA levels than type 1 MI patients. This observation is concordant with the hypothesis that UA might be involved in the pathophysiological mechanisms leading to an imbalance in the oxygen supply/demand ratio in type 2 MI and ischemic myocardial injury.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Larsen TR,Gerke O,Diederichsen ACP,Lambrechtsen J,Steffensen FH,Sand NP,Saaby L,Antonsen S,Mickley H

doi

10.1097/MCA.0000000000000593

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

194-203

issue

3

eissn

0954-6928

issn

1473-5830

journal_volume

29

pub_type

杂志文章
  • Comparison of peripheral arterial tonometry and flow-mediated vasodilation for assessment of the severity and complexity of coronary artery disease.

    abstract:OBJECTIVE:Noninvasive flow-mediated vasodilation (FMD) is a widely used method to assess endothelial function, but its technical difficulty and problems remain obstacles for use in clinical practice. Reactive hyperemia-peripheral arterial tonometry (RH-PAT) was developed as a simpler and more reproducible method. We co...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000094

    authors: Woo JS,Jang WS,Kim HS,Lee JH,Choi EY,Kim JB,Kim WS,Kim KS,Kim W

    更新日期:2014-08-01 00:00:00

  • Angina-linked syncope and lack of calcium antagonist therapy predict cardiac arrest before definitive diagnosis of vasospastic angina.

    abstract:BACKGROUND:Several prognostic factors have been identified in patients with vasospastic angina; however, factors that would predict potentially fatal cardiac arrest during the period between the onset of angina and its definitive diagnosis remain unknown. We investigated the predictive value of the clinical findings th...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章

    doi:

    authors: Igarashi Y,Tamura Y,Tanabe Y,Fujita T,Yamazoe M,Shibata A

    更新日期:1994-11-01 00:00:00

  • Adjunctive pharmacologic therapy in percutaneous coronary intervention: part I antiplatelet therapy.

    abstract::Ischemic heart disease is a major cause of morbidity and mortality throughout the world. Percutaneous coronary intervention (PCI) has rapidly evolved from balloon angioplasty to drug-eluting stents over the past 25 years and has become an important treatment option for coronary heart disease. During PCI, atherosclerot...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/MCA.0b013e32833729e3

    authors: Kim SJ,Giugliano RP,Jang IK

    更新日期:2011-03-01 00:00:00

  • Sequelae of spinal cord stimulation for refractory angina pectoris. Reliability and safety profile of long-term clinical application.

    abstract:BACKGROUND:Spinal cord stimulation (SCS) is effective in the treatment of severe coronary artery disease (CAD) unresponsive to anti-anginal medication or revascularization procedures. However, there is still concern about its safety. OBJECTIVE:To investigate the reliability, morbidity, and mortality aspects of SCS in ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199701000-00005

    authors: Jessurun GA,Ten Vaarwerk IA,DeJongste MJ,Tio RA,Staal MJ

    更新日期:1997-01-01 00:00:00

  • The protection by ischemic preconditioning against myocardial ischemia- and reperfusion-induced arrhythmias is not mediated by ATP-sensitive potassium channels in rats.

    abstract:BACKGROUND:Single or multiple brief periods of myocardial ischemic preconditioning (PC) limits ischemia- and reperfusion-induced arrhythmias. This study tested whether PC protects against ischemia/reperfusion-induced arrhythmias and, if so, whether the protective effect was mediated by the opening of ATP-sensitive (KAT...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199307000-00010

    authors: Lu H,Remeysen P,De Clerck F

    更新日期:1993-07-01 00:00:00

  • Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction.

    abstract:OBJECTIVES:Red cell distribution width (RDW), a measure of red blood cell size heterogeneity, was evaluated in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Higher RDW is associated with mortality in patients with symptomatic car...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e328342c77b

    authors: Uyarel H,Ergelen M,Cicek G,Kaya MG,Ayhan E,Turkkan C,Yıldırım E,Kırbas V,Onturk ET,Erer HB,Yesilcimen K,Gibson CM

    更新日期:2011-05-01 00:00:00

  • Women react with more myocardial ischemia and angina pectoris during elective percutaneous transluminal coronary angioplasty.

    abstract:BACKGROUND:Women have been considered to be at higher risk of complications relating to percutaneous transluminal coronary angioplasty (PTCA) than are men. One reason for this sex-related difference could be the ischemic response of myocardium during the procedure. OBJECTIVE:To investigate whether there are sex-relate...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200010000-00003

    authors: Jensen J,Eriksson SV,Lindvall B,Lundin P,Sylven C

    更新日期:2000-10-01 00:00:00

  • Long-term outcomes in men and women with ST-segment elevation myocardial infarction and incomplete reperfusion after a primary percutaneous coronary intervention: a 2-year follow-up.

    abstract:BACKGROUND:The failure of reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI) is more frequent than considered previously. AIM:To evaluate sex-related differences in long-term outcomes in patients with STEMI and incomplete infarct-related artery reperfusion after a primary percutane...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCA.0000000000000703

    authors: Zachura M,Wilczek K,Janion M,Gąsior M,Gierlotka M,Sadowski M

    更新日期:2019-05-01 00:00:00

  • Predictive value of the combination of age, creatinine, and ejection fraction score and diabetes in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention.

    abstract:BACKGROUND:This study investigated whether the age, creatinine, and ejection fraction (ACEF) score [age (years) /ejection fraction (%) +1 (if creatinine>176μmol/L)] could predict 1-year outcomes following ST-segment elevation myocardial infarction after percutaneous coronary intervention, and whether accuracy could be ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000791

    authors: Gao S,Liu Q,Ding X,Chen H,Zhao X,Li H

    更新日期:2020-03-01 00:00:00

  • Safety and efficacy of a second-generation coronary sirolimus-eluting stent with biodegradable polymers in daily clinical practice: a 12-month follow-up of the ALEX registry.

    abstract:BACKGROUND:Second-generation drug-eluting stents (DESs) have shown higher safety and efficacy compared with first-generation DESs. This effect was achieved by improving biocompatibility using an interalia cobalt-chromium construction, thinner stent struts and biodegradable polymers. OBJECTIVES:To assess clinical and a...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000325

    authors: Hawranek M,Desperak P,Ciślak A,Gąsior P,Gierlotka M,Wąs T,Chodór P,Kowalczyk J,Lekston A,Gąsior M

    更新日期:2016-03-01 00:00:00

  • A randomized comparison of a novel iopromide-based paclitaxel-coated balloon Shenqi versus SeQuent Please for the treatment of in-stent restenosis.

    abstract:BACKGROUND:Treatment of coronary in-stent restenosis (ISR) remains challenging in contemporary clinical applications. Drug-coated balloon (DCB) angioplasty offers an effective treatment for ISR. Shenqi is a novel iopromide-based paclitaxel-coated balloon and its clinical safety, effectiveness and angiographic efficacy ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000994

    authors: Zhu J,Liu L,Zhu Z,Yang Z,Hu J,Ding F,Zhou Y,Su X,Ge J,Liu X,Tang L,He Y,Zhou G,Ji Z,Li Y,Pang W,Zhang R

    更新日期:2020-11-20 00:00:00

  • A new noninvasive method for assessing mild coronary atherosclerosis: transthoracic convergent color Doppler after heart rate reduction. Validation vs. intracoronary ultrasound.

    abstract:BACKGROUND:A more sensitive transthoracic color Doppler technology (convergent color Doppler), along with a heart rate (HR) reduction and new tomographic planes, can greatly improve coronary blood flow velocity (BFV) recordings in the left main (LMCA) and left anterior descending (LAD) coronary arteries, allowing the d...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000873

    authors: Caiati C,Lepera ME,Pollice P,Iacovelli F,Favale S

    更新日期:2020-09-01 00:00:00

  • Effect of angiotensin-converting enzyme inhibitors on the power spectrum of heart rate variability in post-myocardial infarction patients.

    abstract:BACKGROUND:Heart rate variability (HRV) time and frequency domain indices are strong predictors of malignant arrhythmias and sudden cardiac death. The effect of various angiotensin-converting enzyme (ACE) inhibitors on HRV in patients with acute myocardial infarction (AMI) has not been studied. METHODS:Ninety patients...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kontopoulos AG,Athyros VG,Papageorgiou AA,Skeberis VM,Basayiannis EC,Boudoulas H

    更新日期:1997-08-01 00:00:00

  • Drug-coated balloon treatment for nonsmall de-novo coronary artery disease: angiographic and clinical outcomes.

    abstract:OBJECTIVES:Although drug-coated balloons (DCBs) are established for de-novo lesions in small coronary arteries, the impact of DCB treatment according to the reference vessel diameter (RVD) remains poorly defined. This study aimed to evaluate the angiographic and long-term clinical outcomes of DCB treatment for de-novo ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000001006

    authors: Her AY,Yuan SL,Jun EJ,Bhak Y,Kim MH,Garg S,Kim YH,Kun L,Hui L,Zhi W,Hao J,Zhentao S,Qiang T,Shin ES

    更新日期:2021-01-18 00:00:00

  • Prevalence and severity of abnormal glucose regulation and its relation to long-term prognosis after coronary artery bypass grafting.

    abstract:BACKGROUND:Diabetes is a strong predictor of a poor outcome after coronary artery bypass grafting (CABG). The prevalence of prediabetes and its impact on the prognosis after CABG is not well described. In this study, we evaluated the prevalence and prognostic impact of the different states of abnormal glucose regulatio...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e3283645c94

    authors: Petursson P,Herlitz J,Lindqvist J,Sjöland H,Gudbjörnsdottir S

    更新日期:2013-11-01 00:00:00

  • Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry.

    abstract:BACKGROUND:Adiponectin and resistin, which have counteracting effects, are suggested to be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear. The aim of this study was to evaluate the prognostic values of these adipokin...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e328318ecb0

    authors: Lee SH,Ha JW,Kim JS,Choi EY,Park S,Kang SM,Choi D,Jang Y,Chung N

    更新日期:2009-01-01 00:00:00

  • Predictors of atrial fibrillation after coronary artery bypass surgery.

    abstract:OBJECTIVE:Atrial fibrillation is one of the most common arrhythmias associated with not only increased morbidity after coronary artery bypass grafting but also increased healthcare costs. Many factors are associated with atrial fibrillation onset after coronary artery bypass grafting. We prospectively examined which fa...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e3281689a2c

    authors: Dogan SM,Buyukates M,Kandemir O,Aydin M,Gursurer M,Acikgoz S,Yavuzer R,Cam F,Dursun A

    更新日期:2007-08-01 00:00:00

  • Effects of an angiotensin-converting enzyme inhibitor (ramipril) on inflammatory markers in secondary prevention patients: RAICES Study.

    abstract:AIMS:To evaluate the hypothesis that angiotensin-converting enzyme inhibitor therapy with ramipril reduces baseline levels of C-reactive protein in patients at high cardiovascular risk. METHODS:Secondary prevention patients were screened for eligibility and treated with ramipril for 6 month. Baseline and 6-month highl...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/00019501-200510000-00002

    authors: Lopez Santi RG,Valeff EC,Duymovich CR,Mazziotta D,Mijailovsky NE,Filippa GC,Maltez R,Hernandez VA,Monroy AG,Borzi JG,Acheme RA,Etchegoyen MC,PROCORDIS investigators.

    更新日期:2005-11-01 00:00:00

  • Decreased nitrate-mediated dilatation in patients with coronary artery ectasia: an ultrasonographic evaluation of brachial artery.

    abstract:BACKGROUND:Coronary artery ectasia has been defined as localized or diffuse nonobstructive lesions of the epicardial coronary arteries with a luminal dilation exceeding the 1.5-fold of normal adjacent segment or vessel diameter. Although coronary artery disease is supposed to be responsible for more than 50% of coronar...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200606000-00007

    authors: Aksoy Y,Acikgoz N,Sivri N,Bariskaner E,Akturk E,Turhan H,Yetkin E

    更新日期:2006-05-01 00:00:00

  • Predictors of 30-day and 1-year mortality after primary percutaneous coronary intervention for ST-elevation myocardial infarction.

    abstract:OBJECTIVE:Predictors of 30-day mortality may differ from predictors of mortality at 1 year among 30-day survivors of ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). We aimed to evaluate the predictors of 30-day and 1-year mortality in unselected patients with ST...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e32832e5c4c

    authors: Rasoul S,Ottervanger JP,de Boer MJ,Dambrink JH,Hoorntje JC,Marcel Gosselink AT,Zijlstra F,Suryapranata H,van 't Hof AW,Zwolle Myocardial Infarction Study Group.

    更新日期:2009-09-01 00:00:00

  • Frequency-domain optical coherence tomography plaque morphology in stable coronary artery disease: sex differences.

    abstract:BACKGROUND:The cause for discrepancy in the clinical presentation and outcome of coronary artery disease (CAD) between men and women is not established. Different prevalences of risk factors or specific sex-related atherosclerotic aspects have been advocated as possible explanations. We investigated coronary plaque mor...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000522

    authors: Mariani L,Burzotta F,Aurigemma C,Romano A,Niccoli G,Leone AM,Porto I,Trani C,Crea F

    更新日期:2017-09-01 00:00:00

  • Atrial fibrillation, bleeding, and coronary intervention: current recommendations.

    abstract::The patient population with the need for oral anticoagulation to reduce stroke risk associated with atrial fibrillation (AF) and dual antiplatelet therapy to prevent stent thrombosis and myocardial infarction after percutaneous coronary intervention is increasing. However, patients treated with a triple therapy consis...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/MCA.0000000000000549

    authors: Farhan S,Mehran R

    更新日期:2017-12-01 00:00:00

  • The surgical management of congenital coronary artery fistula.

    abstract:BACKGROUND:Congenital coronary artery fistula (CAF) is a very rare cardiovascular anomaly and only 400 cases have been reported. The purpose of this study was to analyse the experience of surgical treatments in CAF and evaluate the surgical indications, techniques and long-term results. METHODS:A retrospective study r...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199412000-00006

    authors: Chen Y,Belboul A,Roberts D

    更新日期:1994-12-01 00:00:00

  • Serum gamma-glutamyl transferase activity increased in patients with coronary artery ectasia.

    abstract:BACKGROUND:Serum gamma-glutamyl transferase (GGT) activity, an enzyme responsible for the extracellular catabolism of antioxidant glutathione, may directly take part in atherogenesis and evolve as a potential biochemical risk indicator of cardiovascular morbidity and mortality. An important characteristic of coronary a...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e32830eaba1

    authors: Sen N,Basar N,Maden O,Ozcan F,Ozlu MF,Gungor O,Turak O,Malcok O,Atak R,Demir AD,Balbay Y

    更新日期:2008-11-01 00:00:00

  • Plasma nuclear and mitochondrial DNA levels in acute myocardial infarction patients.

    abstract:OBJECTIVE:Plasma nuclear and mitochondrial DNA (mtDNA) levels are altered in many diseases. However, it is not known whether they are also altered in acute myocardial infarction (AMI). In the present study, we examined plasma nuclear and mtDNA levels in the patients with AMI before and after a percutaneous coronary int...

    journal_title:Coronary artery disease

    pub_type: 社论

    doi:10.1097/MCA.0000000000000231

    authors: Wang L,Xie L,Zhang Q,Cai X,Tang Y,Wang L,Hang T,Liu J,Gong J

    更新日期:2015-06-01 00:00:00

  • Serum adiponectin and leptin as predictors of the presence and degree of coronary atherosclerosis.

    abstract:BACKGROUND:The association of adipocyte-derived proteins, adiponectin and leptin, with the degree of coronary atherosclerosis has not been not been well elucidated. This study aimed to determine the relationship between serum adiponectin and leptin with the presence and degree of coronary atherosclerosis. METHODS:Seve...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e3283452431

    authors: Hasan-Ali H,Abd El-Mottaleb NA,Hamed HB,Abd-Elsayed A

    更新日期:2011-06-01 00:00:00

  • The effect of glucose-insulin-potassium solution on ventricular late potentials and heart rate variability in acute myocardial infarction.

    abstract:BACKGROUND:Blunted heart rate variability (HRV) and presence of ventricular late potentials (VLPs) are known to correlate with an increased risk of ventricular tachycardia and sudden cardiac death in acute myocardial infarction (AMI). In the present study, we investigated the effect of glucose-insulin-potassium (GIK) s...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00019501-200109000-00010

    authors: Ulgen MS,Alan S,Akdemir O,Toprak N

    更新日期:2001-09-01 00:00:00

  • On the wide spectrum of abnormalities in the coronary arteries of Whipple's disease.

    abstract:BACKGROUND:There is growing interest in the role of microbes in the pathogenesis of coronary atherosclerosis but most of the evidence has been seroepidemiologic. It would be useful to know more about the cytology and histology of coronary lesions containing clearly depicted microbes. OBJECTIVE:To define carefully the ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200103000-00005

    authors: James TN

    更新日期:2001-03-01 00:00:00

  • The cardiac health profile: content, reliability and validity of a new disease-specific quality of life questionnaire.

    abstract:BACKGROUND:The Cardiac Health Profile (CHP) is a new questionnaire for assessing health-related quality of life of patients with cardiovascular diseases. It consists of three parts assessed as follows: the degree of angina pectoris (the CCS scale), the quality of life and subjective scoring of psychosocial 'cost-benefi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:

    authors: Währborg P,Emanuelsson H

    更新日期:1996-11-01 00:00:00

  • Assessment of left ventricular myocardial perfusion and diastolic function during acetylcholine-induced diffuse coronary vasoconstriction by Doppler echocardiography and thallium-201 scintigraphy.

    abstract:BACKGROUND:We investigated whether diffuse coronary vasoconstriction induced by acetylcholine caused myocardial ischemia. METHODS:We studied 30 patients (40 coronary arteries) with spontaneous chest pain or equivocal studies on treadmill exercise testing and no significant coronary stenosis or previous myocardial infa...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:

    authors: Uzui H,Kondo M,Murayama T,Nishiue T,Tsubokawa A,Tanio H,Shimono Y

    更新日期:1995-06-01 00:00:00