Abstract:
BACKGROUND:Adenosine plays a key role in different protective and adaptive responses to ischemia and has been suggested to induce ischemic preconditioning. AIM:To investigate whether a low-dose adenosine infusion reduces the ischemic burden induced by pharmacological stress without affecting the coronary flow reserve (CFR). MATERIALS AND METHODS:Myocardial ischemia was induced by dobutamine stress test and quantified by tissue Doppler echocardiography in 11 patients with advanced coronary artery disease. CFR was quantified during high-dose adenosine infusion by contrast echocardiography. Before the dobutamine stress test and contrast echocardiography, intravenous low-dose adenosine or placebo was infused over 15 min according to a randomized, double-blind, cross-over protocol. Echocardiographic left ventricular (LV) apical images and flow pattern of left anterior descending coronary artery (LAD) were obtained at baseline, during adenosine/placebo infusion, maximal, and recovery phases.Furthermore, the LV walls were categorized as ischemic or nonischemic according to a predefined ischemic threshold of at least 25% increment in peak systolic velocity (PSV)from baseline to maximal stress. CFR was measured as the ratio of peak/baseline of maximal diastolic velocity in the distal LAD. RESULTS:PSV increased both during placebo and adenosine infusions from baseline to maximal stress. However, in the ischemic walls, the PSV increased only during adenosine infusion, whereas no differences were observed in the nonischemic walls. There were no differences in blood pressure, heart rate, or regional CFR during placebo or adenosine infusion. CONCLUSION:Low-dose adenosine infusion improves regional LV systolic function in the ischemic walls, without any effect on CFR, suggesting that the observed improvement may be because of ischemic preconditioning.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Sadigh B,Shahgaldi K,Sylvén C,Quintana M,Winter Rdoi
10.1097/mca.0b013e32832ac5c1subject
Has Abstractpub_date
2009-08-01 00:00:00pages
354-9issue
5eissn
0954-6928issn
1473-5830journal_volume
20pub_type
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199703000-00011
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journal_title:Coronary artery disease
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journal_title:Coronary artery disease
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更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:Considerable evidence suggests that thyroid dysfunction, especially hypothyroidism, may lead to coronary artery disease (CAD). The aim of this study is to investigate the effect of low serum levels of free triiodothyronine (FT3) on coronary artery calcification in outpatients with suspected CAD and the occurr...
journal_title:Coronary artery disease
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doi:10.1097/MCA.0000000000000095
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:17 beta-Estradiol and phytoestrogens are known to have beneficial effects on the cardiovascular systems of women. The exact mechanisms for how estrogens and phytoestrogens influence the cardiovascular system are not yet understood in detail. OBJECTIVE:The objective of this study was to investigate whether 1...
journal_title:Coronary artery disease
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pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199809010-00007
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::Optical coherence tomography (OCT) is the current state-of-the-art intracoronary imaging modality that allows visualization of detailed morphological characteristics of both atherosclerotic plaque and stent. So far, three expert review documents have been released for standardization of OCT image analysis. In the real...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
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更新日期:2014-03-01 00:00:00
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journal_title:Coronary artery disease
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更新日期:2013-09-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
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更新日期:2013-03-01 00:00:00
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journal_title:Coronary artery disease
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更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:The N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is a sensitive indicator of hemodynamic stress and its increased level is associated with higher mortality in acute coronary syndrome (ACS) patients. Virtual histology-intravascular ultrasound (VH-IVUS) can provide quantitative information on plaque ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32832a196e
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Platelets have an important role in coronary thrombosis. METHODS:We studied 151 consecutive patients undergoing implantation of Palmaz-Schatz stents because of suboptimal results after coronary balloon angioplasty treated by intense anticoagulation. Surface exposure of the constitutively expressed glycoprot...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199703000-00001
更新日期:1997-03-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00019501-200007000-00008
更新日期:2000-07-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/00019501-200605000-00013
更新日期:2006-05-01 00:00:00
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journal_title:Coronary artery disease
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更新日期:2009-12-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:1993-05-01 00:00:00
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更新日期:2006-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2017-08-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32832e5c4c
更新日期:2009-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:2002-06-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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更新日期:2018-05-01 00:00:00